Basic Science

Completed projects

Professor Yi Bin FENG

Project Period: 1 April 2019 – 31 March 2021

  • Berberine Suppresses Metastasis and Recurrence of Hepatocellular Carcinoma via Targeting Circulating Tumour Cells (HMRF 16172751)

Professor Zhang Jin ZHANG

Project Period: 1 September 2017 – 31 August 2020

  • Resveratrol and Ginsenoside Rg1 Combination Protects Against Chemotherapy-induced Cognitive Impairment: Synergistic Mechanisms of Cytokine-modulating and Anti-neurotoxic Actions (GRF 17115017)

Professor Jian Gang SHEN

Project Period: 1 September 2017 – 31 August 2020

  • Exploring Molecular Targets for Drug Discovery to Preventing Hyperglycemia-mediated Hemorrhagic Transformation in Ischemic Stroke: Sodium Danshensu (SDSS) as an Example (GRF 17118717)

Project Period: 1 January 2016 – 31 December 2019

  • Investigating the Role of Reactive Nitrogen-mediated Excessive Mitophagy in Cerebral Ischemia-reperfusion Injury and the Intervention Effect of Antioxidant Naringin (NFSC 31570855)

Project Period: 1 June 2016 – 30 September 2018

  • Exploring Molecular Targets for Drug Discovery to Preventing Hyperglycemia-mediated Hemorrhagic Transformation in Ischemic Stroke: Sodium Danshensu (SDSS) as an Example (GRF 17118717)

Professor Jian Hui RONG

Project Period: 1 January 2018 – 31 December 2020

  • Plant-derived Celastrol Ameliorates Metabolic Dysfunctions, Oxidative Stress and Inflammation in Diet-induced Obesity via Disrupting the Cross-talk between PKM2, HIF-1α and IL-1β (GRF 17100317)

Project Period: 1 January 2018 – 31 December 2021

  • Arachidonic Acid Metabolite (15-keto-PGF2α) Regulates Macrophage M1/M2 Polarization against Myocardial Ischemia Reperfusion Injury via Covalent Conjugation with Glycolytic Enzyme PKM2 (NSFC 21778046)

Project Period: 1 April 2019 – 31 March 2022

  • Pharmacological Induction of Pro-resolving Macrophages for Suppressing Cardiac Fibrosis in Experimental Myocardial Infarction (HMRF 16171751)

Professor Hai Yong CHEN

Project Period: 1 January 2017 – 31 December 2020

  • The Latent TGF-β Protects against Diabetic Kidney Disease via GARP-latent TGF-β Mediated Anti-inflammation: Mechanism and Therapeutic Potential (GRF 17113416)

Project Period: 1 December 2020 – 31 March 2022

  • An Evidence-based Research and Promotion of Chinese Medicine for COVID-19 (CMDF AR200018)

Professor Xiang LIN

Project Period: 15 April 2020 – 14 April 2021

  • Heat-cooling Chinese Herbs in Treating Chronic Hepatitis B Patients Comparing with Antiviral Therapy: A Systematic Review and Network Meta-analysis (HMRF 17181101)

Professor Ning WANG

Project Period: 1 April 2018 – 31 March 2020

  • Investigation on the Effect of Berberine on Improvement of Diabetic Retinopathy in Insulin-treated Diabetic Mellitus (HMRF 15162961)

Project Period: 1 April 2021 – 31 March 2022

  • Development of Training Platform of the Toxicity, Safety and Proper Application of Chinese Medicine for Chinese Medicine-related Practitioners (CMDF AR200032)
On-going projects

Professor Yi Bin FENG

Project Period: 1 September 2021 – 31 August 2023

  • Elucidation of the Reversal Effect of Baicalin on Hepatocellular Carcinoma-associated Cachexia (HMRF 18192141)

Project Period: 1 December 2019 – 30 November 2022

  • Inhibitory Effect of the Natural Compound Fangchinoline from Stephania Tetrandra S. Moore on Human Liver Cancer Stem Cells (GRF 17121419)

Professor Jian Gang SHEN

Project Period: 1 October 2020 – 30 September 2023

  • Elucidating the Roles of Hypochlorous Acid (HOCl) in Mediating Hemorrhage Transformation (HT) in Ischemic Stroke with Delayed Thrombolytic Therapy and its Application for Therapeutic Approach with Acteoside (RGF 17105220)

Professor Jian Hui RONG

Project Period: 1 January 2020 – 31 December 2022

  • Chinese Medicine Pentacyclic Triterpene Celastrol Ameliorates Inflammation, Metabolic Dysfunctions and Insulin Resistance in Diet-induced Obesity via Covalently Modifying Endoplasmic Reticulum Chaperone GRP78 (GRF 17119619)

Project Period: 1 July 2019 – 30 June 2022

  • CCK-B Receptor Antagonists for the Treatment of Depression Especially Chronic Pain Comorbid Depression of Elderly ((MRP) 053/18X)

Professor Hai Yong CHEN

Project Period: 1 July 2019 – 30 June 2022

  • Blockade of Smad3 Attenuates Diabetic Nephropathy via Suppressing C-reactive Protein-mediated NLPR3 Inflammasome Activation (GRF 17109019)

Professor Xiang LIN

Project Period: 1 January 2022 – 31 December 2024

  • Role of Caveolin-1 in Regulating T Cell Responses in Primary Sjogren’s Syndrome (RGC GRF 17116521)

Project Period: 1 January 2021 – 31 December 2023

  • Novel Therapeutic Strategy for Sjogren’s Syndrome: Targeting Myeloid-Derived Suppressor Cells (RGC ECS 27111820)

Professor Ning WANG

Project Period: 1 December 2021 – 30 November 2024

  • Investigation of the Effect of Berberine to Overcome Sorafenib Resistance in Human Hepatocellular Carcinoma via Suppressing Warburg Effect (GRF 14119621)

Project Period: 1 August 2020 – 31 July 2022

  • Investigation, Optimization and Evaluation of Traditional Chinese Medicine Processing Technology “Nine Steaming and Nine Drying” – Taking the Rhizomes Zhongle He Shou Bird, Huang Jing and Rehmannia Glutinosa as Examples (CMDF AR200001)

Dr Jian Ping CHEN

Project Period: 1 February 2021 – 31 July 2022

  • The Novel Oral Administration Isoliquiritigenin-Protein/Zein Nanodrug Targeting for Triple-Negative Breast Cancer Treatment (RTH-ITF InP/128-21; RTH-IFT PiH/102/21; PiH/426/20)