Professoriate Staff

Professor Zhang-Jin ZHANG
Professor, Coordinator of CM Service for Hospital & Development, School of Chinese Medicine,
The University of Hong Kong (HKU)
Chief of Service (COS), Department of Chinese Medicine, HKU-Shenzhen Hospital
Acting Chief of Service (COS), Department of Chinese Medicine, Gleneagles Hospital
  • School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong
  • (852) 3917 6445
  • (852) 2872 5476
  • zhangzj@hku.hk
EDUCATION
1985 BMed - Shanghai University of Traditional Chinese Medicine
1988 MMed - Xi'an Jiaotong University College of Medicine
1991 PhD - Xi'an Jiaotong University College of Medicine
MAJOR APPOINTMENTS
2013 – present Professor, School of Chinese Medicine, the University of Hong Kong, HK
2006 – 2012 Associate Professor, School of Chinese Medicine, the University of Hong Kong, HK
2001 – 2006 Research Assistant Professor, Department of Psychiatry, Uniformed Services University of the Health Sciences (USUHS), Bethesda, Maryland, USA
1995 – 2001 Research Fellow, Department of Psychiatry, Vanderbilt University, Nashville, Tennessee, USA
1996 – 1997 Visiting Scientist, Experimental Neurology Laboratory, Veteran Administration Medical Centre at Nashville, Tennessee, USA
1993 – 1995 Associate Professor and Vice Chairman, Department of Human Anatomy, Xi’an Jiaotong University College of Medicine, Xi'an, China
1988 – 1993 Instructor, Department of Human Anatomy, Xi’an Jiaotong University College of Medicine, Xi’an, China
MAJOR TEACHING COURSES
  • CCCH9029 Ideas and practices of healing art in traditional China: Coordinator and Lecturer
  • BCHM5604 Acupuncture and Moxibustion: Lecturer
  • BCHM3801 Introduction to Chinese Medicine & Nursing: Coordinator and Lecturer
  • MCHM6102 Biomedical Course allied to Acupuncture: Coordinator and Lecturer
CLINICAL SERVICES

    Professor Zhang is an internationally renowned expert in specializing acupuncture and Chinese medicine treatment of neurological and psychiatric diseases, including pain disorders, stroke rehabilitation, neurodegenerative diseases, insomnia, depressive disorders, anxiety and panic disorders, post-traumatic stress disorder (PTSD), bipolar disorder, obsessive compulsive disorder (OCD), tic disorders, and schizophrenia.


    Appointment phone number: (852)3917-6433 at Sassoon Road Clinic; (852)3153-9148 at Gleneagles Hospital.

RESEARCH INTERESTS
  • • Develop effective treatment strategies from acupuncture and Chinese medicines for major neurological and psychiatric disorders through basic and clinical studies.
  • • Characterize neuropsychopharmacological and therapeutic properties of novel constituents extracted from medicinal plants with the employment of behavioral, molecular, and biochemical approaches
  • • Neural mechanisms of acupuncture effects
  • • Nerve and brain stimulation
ONGOING CLINICAL TRIALS
PUBLICATIONS (* corresponding author)
Acupuncture and brain stimulation
  1. Li X, Jia HX, Yin DQ, Zhang ZJ*. Acupuncture for metabolic syndrome: systematic review and meta-analysis. Acupuncture in Medicine 2020; 9:964528420960485.
  2. Guo X, Zhao Y, Huang F, Li S, Luo M, Wang Y, Zhang J, Li L, Zhang Y, Jiao Y, Zhao B, Wang J, Meng H, Zhang ZJ*, Rong PJ*. Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Peripheral and Central Tumor Necrosis Factor Alpha in Rats with Depression-Chronic Somatic Pain Comorbidity. Neural Plasticity 2020;2020: 8885729.
  3. Zheng Y, Qin Z, Tsoi B, Shen J, Zhang ZJ*. Electroacupuncture on Trigeminal Nerve-Innervated Acupoints Ameliorates Poststroke Cognitive Impairment in Rats with Middle Cerebral Artery Occlusion: Involvement of Neuroprotection and Synaptic Plasticity. Neural Plast. 2020 Sep 7;2020:8818328.
  4. Zhang ZJ*, Man SC, Yam LL, Yiu CY, Leung RC, Qin ZS, Chan KS, Lee VHF, Kwong A, Yeung WF, So WKW, Ho LM, Dong YY. Electroacupuncture trigeminal nerve stimulation plus body acupuncture for chemotherapy-induced cognitive impairment in breast cancer patients: An assessor-participant blinded, randomized controlled trial. Brain Behav Immun. 2020; 88:88-96.
  5. Cheung DST, Tiwari A, Yeung WF, Yu DSF, So MKP, Chau PH, Wang XM, Lum TYS, Yuk Fung HYK, Ng BYM, Zhang ZJ, Lao L. Self-Administered Acupressure for Caregivers of Older Family Members: A Randomized Controlled Trial. J Am Geriatr Soc. 2020;68(6):1193-1201.
  6. Zhang ZJ*, Zhao H, Jin GX, Man SC, Wang YS, Wang Y, Wang HR, Li MH, Yam LL, Qin ZS, Yu KKT, Wu J, Ng FLB, Ziea TCE, Rong PJ. An assessor-participant blinded, randomized controlled trial of dense cranial electroacupuncture stimulation plus body acupuncture for neuropsychiatric sequelae of stroke. Psychiatry & Clinical Neuroscience 2020;74(3):183-190.
  7. Jia J, Shen J, Liu FH, Wong HK, Yang XJ, Wu QJ, Zhang H, Wang HN, Tan QR, Zhang ZJ*. Effectiveness of electroacupuncture and electroconvulsive therapy as additional treatment in hospitalized patients with schizophrenia: a retrospective controlled study. Front. Psychol. 2019;10:2306.
  8. Feng B, Zhang Y, Luo LY, Wu JY, Yang SJ, Zhang N, Tan QR, Wang HN, Ge N, Ning F, Zheng ZL, Zhu RM, Qian MC, Chen ZY, Zhang ZJ*. Transcutaneous electrical acupoint stimulation for posttraumatic stress disorder: an assessor-blinded, randomized controlled study. Psychiatry and Clinical Neurosciences 2019;73:179-186.
  9. Yeung WF, Chung KF, Zhang ZJ, Zhang SP, Chan WC, Ng MKR, Chan CLW, Ho LM, Yu BYM, Chau JCS, Lau NCL, Lao LX. Electroacupuncture for tapering off long-term benzodiazepine use: a randomized controlled trial. Journal of Psychiatric Research 2019;109:59-67.
  10. Yang JW, Shi GX, Zhang S, Tu JF, Wang LQ, Yan CQ, Lin LL, Liu BZ, Wang J, Sun FS, Yang BF, Wu LY, Tan C, Chen S, Zhang ZJ, Fisher M, Liu CZ. Effectiveness of Acupuncture for Vascular Cognitive Impairment No Dementia: A Randomized Controlled Trial. Clinical Rehabilitation 2019;33(4):642-652.
  11. Zhou CH, Xue F, Xue SS, Sang HF, Liu L, Wang Y, Cai M, Zhang ZJ, Tan QR, Wang HN, Peng ZW. Electroacupuncture Pretreatment Ameliorates PTSD-Like Behaviors in Rats by Enhancing Hippocampal Neurogenesis via the Keap1/Nrf2 Antioxidant Signaling Pathway. Front Cell Neurosci. 2019;13:275.
  12. Chung KF, Yeung WF, Yu BY, Leung FC, Zhang SP, Zhang ZJ, Ng RM, Yiu GC. Acupuncture with or without combined auricular acupuncture for insomnia: a randomised, waitlist-controlled trial. Acupunct Med. 2018;36:2-13.
  13. Yeung WF, Ho FY, Chung KF, Zhang ZJ, Yu BY, Suen LK, Chan LY, Chen HY, Ho LM, Lao LX. Self-administered acupressure for insomnia disorder: a pilot randomized controlled trial. J Sleep Res. 2018;27(2):220-231.
  14. Wang HN, Wang XX, Zhang RG, Wang Y, Cai M, Zhang YH, Sun RZ, Guo L, Qiao YT, Liu JC, He H, Wang ZH, Wan YC, Tan QR, Zhang ZJ*. Clustered repetitive transcranial magnetic stimulation for the prevention of depressive relapse/recurrence: a randomized controlled trial. Translational Psychiatry 2017;7:1292.
  15. Yeung WF, Ho FY, Chung KF, Zhang ZJ, Yu BY, Suen LK, Chan LY, Chen HY, Ho LM, Lao LX.. Self-administered acupressure for insomnia disorder: a pilot randomised controlled trial. Journal of Sleep Research 2018;27:220-231.
  16. Yeung WF, Chung KF, Zhang ZJ, Chan WC, Zhang SP, Ng RM, Chan CL, Ho LM, Yu YM, Lao LX. Electroacupuncture for tapering off long-term benzodiazepine use: study protocol of randomized controlled trial. BMC Complement Altern Med. 2017;31:17:183.
  17. Tiwari A, Lao L, Wang AX, Cheung DS, So MK, Yu DS, Lum TY, Yuk Fung HY, Yeung JW, Zhang ZJ. Self-administered acupressure for symptom management among Chinese family caregivers with caregiver stress: a randomized, wait-list controlled trial. BMC Complement Altern Med. 2016;16(1):424.
  18. Feng B, Zhang ZJ*, Zhu RM, Yuan GZ, Luo LY, McAlonan GM, Xu FZ, Chen J, Liu LY, Lv YY, Wong HK, Zhang Y, Zhu LX. Transcutaneous electrical acupoint stimulation as an adjunct therapy for obsessive-compulsive disorder: a randomized controlled study. Journal of Psychiatric Research, 2016; 80:30-37.
  19. Chung KF, Yeung WF, Zhang SP, Zhang ZJ, Wong MT, Lee WK, Chan KW. Acupuncture for persistent insomnia associated with major depressive disorder: a randomised controlled trial. Hong Kong Med J. 2016;22(Suppl 2):9-14.
  20. Guo Y, Cao DY, Zhang ZJ, Yao FR, Wang HS, Zhao Y. Electrical signal propagated across acupoints along Foot Taiyang Bladder Meridian in rats. Chin J Integr Med. 2016;22:537-544.
  21. Chung KF, Yeung WF, Yue YM, Kwok CW, Zhang SP, Zhang ZJ. Adverse events related to acupuncture: development and testing of a rating scale. The Clinical Journal of Pain. 2015;31(10):922-928.
  22. Chung KF, Yeung WF, Yu YM, Yung KP, Zhang SP, Zhang ZJ, Wong MT, Lee WK, Chan LW. Acupuncture for residual insomnia associated with major depressive disorder: a placebo- and sham-controlled, subject- and assessor-blind, randomized trial. The Journal of Clinical Psychiatry 2015;76:e752-e760.
  23. Lian WL, Pan MQ, Zhou DH, Zhang ZJ*. Effectiveness of acupuncture for palliative care in cancer patients: A systematic review. Chin J Integr Med. 2014;20(2):136-147.
  24. Chen JQ, Lin WR, Wang SX, Wang CQ, Li GL, Qu SS, Huang Y, Zhang ZJ*, Xiao W. Acupuncture/electroacupuncture enhances antidepressant effect of Seroxat: the Symptom Checklist-90 scores. Neural Regeneration Research 2014;9(2):213-222.
  25. Cheong KB, Zhang JP, Huang Y, Zhang ZJ. The Effectiveness of acupuncture in prevention and treatment of postoperative nausea and vomiting – a systematic review and meta-analysis. PloS ONE 2013;8(12): e82474. doi:10.1371/journal.pone.0082474.
  26. Chen HY, Li SG, Cho WCS, Zhang ZJ*. The Role of acupoint stimulation as an adjunct therapy for lung cancer: a systematic review and meta-analysis. BMC Complementary and Alternative Medicine 2013;13:362.
  27. Zhang ZJ*, Ng R, Man SC, Li JT, Wong W, Wong HK, Wang D, Wong MT, Tsang AW, Yip KC, Sze SC. Use of electroacupuncture to accelerate the antidepressant action of selective serotonin reuptake inhibitors: a single-blind, randomised, controlled study. Hong Kong Med J. 2013;19 (Suppl 9):12-16.
  28. Huang Y, Chen JQ, Lai XS, Tang CZ, Yang JJ, Chen H, Wu JX, Xiao HL, Qu SS, Zhang YD, Zhang ZJ*. Lateralisation of cerebral response to active acupuncture in patients with unilateral ischemic stroke – an fMRI study. Acupunct Med. 2013;31:290-296.
  29. Qu SS, Huang Y, Zhang ZJ*, Chen JQ, Lin RY, Wang CQ, Li GL, Wong HK, Zhao CH, Pan JY, Guo SC, Zhang YC. A 6-week randomized controlled trial with 4-week follow-up of acupuncture combined with paroxetine in patients with major depressive disorder Journal of Psychiatric Research 2013;47:726-732.
  30. Zheng Y, Qu S, Wang N, Liu L, Zhang G, Jiang X, Chen J, Huang Y, Zhang Z. Post-stimulation effect of electroacupuncture at Yintang (EX-HN3) and GV20 on cerebral functional regions in healthy volunteers: a resting functional MRI study. Acupunct Med. 2012;30:307–315.
  31. Yeung WF, Chung KF, Poon MMK, Ho FYY, Zhang SP, Zhang ZJ, Ziea ETC, Wong VT. Prescription of Chinese herbal medicine and selection of acupoints in pattern-based traditional Chinese medicine treatment for insomnia: a systematic review. Evidence-based Complementary and Alternative Medicine 2012;2012:902578.
  32. Yeung WF, Chung KF, Poon MK, Ho YY, Zhang SP, Zhang ZJ, Ziea TC, Wong VT. Acupressure, reflexology, and auricular acupressure for insomnia: a systematic review of randomized controlled trials. Sleep Medicine 2012;13(8):971-984.
  33. Chung KF, Yeung WF, Zhang ZJ, Yung KP, Man SC, Lee CP, Lam SK, Leung TW, Leung KY, Ziea ETC, Wong VT. Randomized placebo-controlled pilot trial of electroacupuncture for postpartum depression. Journal of Affective Disorders 2012; 142(1-3):115-21.
  34. Zhang ZJ*, Ng R, Man SC, Li TYJ, Wong W, Tan QR, Wong  HK, Chung KF, Wong MT, Tsang WKA, Yip KC, Ziea E, Wong VT. Wang D, Ng R, Wong VT. Dense cranial electroacupuncture stimulation for major depressive disorder: a single-blind, randomized, controlled study. PLoS ONE 2012;7(1): e29651.
  35. Zhang ZJ*, Wang XM, McAlonan GM. Neural acupuncture unit: a new concept for interpreting effects and mechanisms of acupuncture. Evidence-based Complementary and Alternative Medicine 2012; Vol. 2012, Article ID 429412, 23 pages, doi:10.1155/2012/429412.
  36. Zhang ZJ, Chen YC, Wang HN, Wang HH, Xue YY, Feng SF, Tan QR. Electroconvulsive therapy improves antipsychotic and somnographic responses in adolescents with first-episode psychosis – a case-controlled study. Schizophrenia Research 2012;137(1-3):97-103. 
  37. Yeung WF, Chung KF, Poon MK, Ho YY, Zhang SP, Zhang ZJ, Ziea TC, Wong VT. Chinese herbal medicine for insomnia: a systematic review of randomized controlled trials. Sleep Medicine Reviews 2012;16(6):497-507.
  38. Fasmer OB,  Liao H, Huang Y, Berle JØ, Wu J, Oedegaard KJ, Wik G, Zhang ZJ. A naturalistic study of the effect of acupuncture on heart-rate variability. J Acupunct Meridian Stud 2012;5(1):15-20. 
  39. Yeung WF, Chung KF, Tso KC, Shi-Ping Zhang SP, Zhang ZJ, Ho LM. Electroacupuncture for residual insomnia associated with major depressive disorder: a randomized controlled trial. Sleep 2011;34:807-815.
  40. Zhang ZJ*, Chen HY, Yip KC, Ng R, Wong V. The effectiveness and safety of acupuncture therapy in depressive disorders: systematic review and meta-analysis. Journal of Affective Disorders 2010;124(1-2):9-21.
  41. Zhang ZJ*, Wang XY, Tan QR, Jin GX, Yao SM. Electroacupuncture for refractory obsessive-compulsive disorder - a pilot, waitlist-controlled trial. Journal of Nervous and Mental Disease 2009;197(8):619-622.
  42. Psychopharmacology and pharmacology of Chinese medicines
  43. Sarris J, Marx W, Ashton MA, Ng C, Galvao-Coelho N, Ayati Z, Zhang ZJ, Kasper S, Ravindran A, Harvey BH, Lopresti A, Mischoulon D, Amsterdam J, Yatham L, Berk M. Plant-Based Medicines (Phytoceuticals) in the Treatment of Psychiatric Disorders: a meta-review of meta-analyses of randomized controlled trials. Canadian J Psychiatry 2020 (in press).
  44. Xu Y, Wang N, Tan HY, Li S, Zhang C, Zhang ZJ, Feng YB. Panax notoginseng saponins modulate the gut microbiota to promote thermogenesis and beige adipocyte reconstruction via leptin-mediated AMPKα/STAT3 signaling in diet-induced obesity. Theranostics. 2020;10(24):11302-11323.
  45. Zhou XD, Yang XJ, Zheng Y, Qin ZS, Chen G, Zhang ZJ*. Jie-Yu Pill, A Proprietary Herbal Medicine, Ameliorates Mood Disorder-Like Behavior and Cognitive Impairment in Estrogen-Deprived Mice Exposed to Chronic Unpredictable Mild Stress: Implication for a Potential Therapy of Menopause Syndrome. Frontiers in Psychiatry 2020; DOI: 10.3389/fpsyt.2020.579995.
  46. Li S, Wang N, Tan HY, Chueng F, Zhang ZJ, Yuen MF, Feng Y. Modulation of gut microbiota mediates berberine-induced expansion of immuno-suppressive cells to against alcoholic liver disease. Clin Transl Med. 2020 Aug;10(4):e112.
  47. Zhou XD, Zheng Y, Sharma R, Zhang ZJ*. Total Polysaccharides of Lily Bulb Ameliorate Menopause-Like Behavior in Ovariectomized Mice: Multiple Mechanisms Distinct from Estrogen Therapy. Oxidative Medicine and Cellular Longevity, 2019; 2019:6869350.
  48. Zhou XD, Shi DD, Zhang ZJ*. Ameliorative effects of Radix rehmanniae extract on the anxiety- and depression-like symptoms in ovariectomized mice: A behavioral and molecular study. Phytomedicine. 2019;63:153012.
  49. Zhou XD, Shi DD, Wang HN, Tan QR, Zhang ZJ*. Aqueous extract of lily bulb ameliorates menopause-like behavior in ovariectomized mice with novel brain-uterus mechanisms distinct from estrogen therapy. Biomed Pharmacother. 2019;117: 109114.
  50. Khan H, Reale M, Ullah H, Sureda A, Tejada S, Wang Y, Zhang ZJ*, Xiao J. Anti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions. Biotechnol Adv. 2019 Apr 18. pii: S0734-9750(19)30066-7.
  51. Cheng IC, Li RK, Leung GP, Li SL, Kong M, Lao LX, Zhang ZJ, Lin WL, Ng EH, Rong JH, Chen JP, Su J, Zhang KY, Meng W. Application of UPLC-MS/MS to simultaneously detect four bioactive compounds in the tumour-shrinking decoction (FM1523) for uterine fibroids treatment. Phytochem Anal. 2019 Mar 27. doi: 10.1002/pca.2827. [Epub ahead of print]
  52. Shi DD, Huang YH, Lai CSW, Dong CM, Ho LC, Li XY, Wu EX, Li Q, Wang XM, Chen YJ, Chung SK, Zhang ZJ*. Ginsenoside Rg1 prevents chemotherapy-induced cognitive impairment: associations with microglia-mediated cytokines, neuroinflammation, and neuroplasticity. Molecular neurobiology 2019;56(8):5626-5642.
  53. Zhou XD, Shi DD, Zhang ZJ*. Antidepressant and anxiolytic effects of the proprietary Chinese medicine Shexiang Baoxin pill in mice with chronic unpredictable mild stress. Journal of Food and Drug Analysis. 2019;27(1):221-230.
  54. Liu JY, Chen XX, Chen HY, Shi J, Leung GPH, Tang SCW, Lao LX, Yip HKF, Lee KF, Sze SCW, Zhang ZJ*, Zhang KY*. Downregulation of aquaporin 9 exacerbates beta-amyloid-induced neurotoxicity in Alzheimer’s disease models in vitro and in vivo. Neuroscience 2018;394:72-82.
  55. Shi DD, Huang YH, Lai CSW, Dong CM, Ho LC, Wu EX, Li Q, Wang XM, Chung SK, Sham PC, Zhang ZJ*. Chemotherapy-induced cognitive impairment is associated with cytokine dysregulation and disruptions in neuroplasticity. Molecular neurobiology 2019; 56(3):2234–2243.
  56. Saligan LN, Lukkahatai N, Zhang ZJ, Wang XM. Altered Cd8+ T lymphocyte Response Triggered by Arg-1: Implication for Fatigue Intensification after Localized Radiation Therapy in Prostate Cancer Patients. Neuropsychiatry (London) 2018; (2018) 8(4), 1249–1262.
  57. Ng SM, Lingli Leng LL, Ho RTH, Zhang ZJ, Wang Q. A Brief Body-Mind-Spirit Group Therapy for Chinese Medicine Stagnation Syndrome: A Randomized Controlled Trial. eCAM 2018;2018:e8153637.
  58. Shi DD, Dong CM, Ho LC, Lam CTW, Zhou XD, Wu EX, Zhou ZJ, Wang XM, Zhang ZJ*. Resveratrol, a natural polyphenol, prevents chemotherapy-induced cognitive impairment: involvement of cytokine modulation and neuroprotection. Neurobiology of Disease. 2018; 114:164-173.
  59. Chen XX, Lam KH, Chen QX, Leung GP, Tang SCW, Sze SC, Xiao JB, Feng F, Wang Y, Zhang KY, Zhang ZJ. Ficus virens proanthocyanidins induced apoptosis in breast cancer cells concomitantly ameliorated 5-fluorouracil induced intestinal mucositis in rats. Food Chem Toxicol. 2017;110:49-61.
  60. Zhang QL, Fu BM, Zhang ZJ*. Borneol, a novel agent that improves central nervous system drug delivery by enhancing blood-brain barrier permeability. Drug Delivery 2017; 24:1037-1044.
  61. Chen XX, Leung GP, Zhang ZJ, Xiao JB, Lao LX, Feng F, Mak JC, Wang Y, Sze SC, Zhang KY. Proanthocyanidins from Uncaria rhynchophylla induced apoptosis in MDA-MB-231 breast cancer cells while enhancing cytotoxic effects of 5-fluorouracil. Food Chem Toxicol. 2017;107(Pt A):248-260.
  62. Cheung HP, Wang SW, Ng TB, Zhang YB, Lao LX, Zhang ZJ, Tong Y, Chung FW, Sze SC. Comparison of chemical profiles and effectiveness between Erxian decoction and mixtures of decoctions of its individual herbs: a novel approach for identification of the standard chemicals. Chin Med. 2017;12:1.
  63. Wang SW, Cheung HP, Tong Y, Lu J, Ng TB, Zhang YB, Zhang ZJ, Lee KF, Lam JK, Sze SC. Steroidogenic effect of Erxian decoction for relieving menopause via the p-Akt/PKB pathway in vitro and in vivo. J Ethnopharmacol. 2017;195:188-195.
  64. Man SC, Li XB, Wang HH, Yuan HN, Wang HN, Zhang RG, Tan QR, Wong HK, McAlonan GM, Wang CY, Zhang ZJ*. Peony-Glycyrrhiza Decoction for antipsychotic-related hyperprolactinemia in women with schizophrenia: a randomized controlled trial. Journal of Clinical Psychopharmacology 2016;36: 572–579.
  65. Tian DD, Wang W, Wang HN, Sze SCW, Zhang ZJ*. Pharmacokinetic evaluation of clozapine in concomitant use of Radix Rehmanniae, Fructus Schisandrae, Radix Bupleuri, and Fructus Gardeniae in rats. Molecules 2016;21(6). pii: E696. 
  66. Wang W, Tian DD, Zhang ZJ*. In-vitro effects of concomitant use of herbal preparations on cytochrome P450s involved in clozapine metabolism. Molecules 2016; 21(5). pii: E597.
  67. Leigh AB, Cheung HP, Lin LZ, Ng TB, Lao L, Zhang Y, Zhang ZJ, Tong Y, Sze SC. Comprehensive and Holistic Analysis of HT-29 Colorectal Cancer Cells and Tumor-Bearing Nude Mouse Model: Interactions Among Fractions Derived From the Chinese Medicine Formula Tian Xian Liquid in Effects on Human Colorectal Carcinoma. Integrative Cancer Therapies 2016; pii: 1534735416651969.
  68. Wang D, Zhang Y, Wang C, Jia D, Cai G, Lu J, Wang D, Zhang ZJ*. 18β-Glycyrrhetinic acid, a novel naturally derived agent, suppresses prolactin hyperactivity and reduces antipsychotic-induced hyperprolactinemia in in vitro and in vivo models. Neurochemical Research, 2016;41(9):2233-2242. 
  69. Li S, Tan HY, Wang N, Zhang ZJ, Lao LX, Wong CW, Feng YB. The Role of Oxidative Stress and Antioxidants in Liver Diseases. International Journal of Molecular Sciences 2015;16(11):26087-26124
  70. Wang D, Wang W, Zhou Y, Wang J, Jia D, Wong HK, Zhang ZJ*. Studies on the regulatory effect of Peony-Glycyrrhiza Decoction on prolactin hyperactivity and underlying mechanism in hyperprolactinemia rat model. Neuroscience Letters, 2015; 606;60-65.
  71. Wang S, Tong Y, Ng TB, Lao L, Lam JK, Zhang KY, Zhang ZJ, Sze SC. Network pharmacological identification of active compounds and potential actions of Erxian decoction in alleviating menopause-related symptoms. Chin Medicine 2015;10:19.
  72. Wang W, Tian DD, Zheng B, Wang D, Tan QR, Wang QY, Zhang ZJ*. Peony-Glycyrrhiza Decoction, an herbal preparation, inhibits clozapine metabolism via cytochrome P450s, but not flavin-containing monooxygenase in in vitro models. Drug Metabolism & Disposition, 2015;43:1147-1153.
  73. Zheng Y, Zhang ZJ*, Han XM, Ding Y, Chen YY, Wang XY, Wei XW, Wang MJ, Cheng Y, Nie ZH, Zhao M, Zheng XX. A proprietary herbal medicine (5-Ling Granule) for Tourette syndrome: a randomized controlled trial. The Journal of Child Psychology and Psychiatry, 2016; 57(1):74-83.
  74. Wong KL, Lai YM, Li KW,  Lee KF, Ng TB, Cheung HP, Zhang YB, Lao L, Wong NSR, Shaw PC, Wong JH, Zhang ZJ, Lam JKW, Ye W, Sze SCW. A novel, stable, estradiol-stimulating, osteogenic yam protein with potential for the treatment of menopausal syndrome. Scientific Reports 2015;5:10179.
  75. Wang N, Feng Y, Cheung F, Wang X, Zhang Z, Feng Y.A Chinese Medicine Formula Gegen Qinlian Decoction Suppresses Expansion of Human Renal Carcinoma With Inhibition of Matrix Metalloproteinase-2. Integr Cancer Ther. 2015;14:75-85.
  76. Liu LY, Feng B, Chen J, Tan QR, Chen ZX, Chen WS, Wang PR, Zhang ZJ*. Herbal medicine for hospitalized patients with severe depressive episode: a retrospective controlled study. Journal of Affective Disorders 2015;170:71-77.
  77. Wong KL, Wong RNS, Zhang L, Liu WK, Ng TB, Shaw PC, Kwok PCL, Lai YM, Zhang ZJ, Zhang YB, Tong Y, Cheung HP, Liu J, Sze SCW. Bioactive proteins and peptides isolated from Chinese medicines with pharmaceutical potential. Chinese Medicine 2014;9:19.
  78. Man MSC, Hung BHB, Ng RMK, Yu XC, Cheung H, Fung MPM, Li LSW, Leung KP, Leung KP , Tsang K, Ziea E, Wong VT, Zhang ZJ*. A pilot controlled trial of a combination of dense cranial electroacupuncture stimulation and body acupuncture for post-stroke depression. BMC Complementary and Alternative Medicine 2014, 14:255.
  79. Wang D, Lu CY, Teng LS, Guo ZH, Meng QF, Liu Y, Zhong LLD, Wang W, Xie J, Zhang ZJ*. Therapeutic effects of Chinese herbal medicine against neuroendocrinological diseases especially related to hypothalamus-pituitary-adrenal and hypothalamus-pituitary-gonadal axis. Pakistan Journal of Pharmaceutical Sciences 2014; 27(3 Supp):741-754.
  80. Wang H, Zhang R, Qiao Y, Xue F, Nie H, Zhang Z, Wang Y, Peng Z, Tan Q. Gastrodin ameliorates depression-like behaviors and up-regulates proliferation of hippocampal-derived neural stem cells in rats: Involvement of its anti-inflammatory action. Behav Brain Res. 2014;266:153-160.
  81. Chen HY, Ma CH, Cao KJ, Ho CM, Ziea ETC, Wong VT, Zhang ZJ*. A systematic review and meta-analysis of herbal medicine on chronic obstructive pulmonary diseases. eCAM 2014; 925069.
  82. Wang N, Zhu M, Tsao SW, Man K, Zhang ZJ, Feng Y. MiR-23a-mediated inhibition of topoisomerase 1 expression potentiates cell response to etoposide in human hepatocellular carcinoma. BMC Molecular Cancer 2013;12:119.
  83. Wang D, Wong HK, Feng YB, Zhang ZJ*. 18b-Glycyrrhetinic acid induces apoptosis in pituitary adenoma cells via ROS/MAPKs-mediated pathway. Journal of Neuro-Oncology 2014;116(2):221-230.
  84. Wang D, Wong HK, Feng YB, Zhang ZJ*. Liquiritigenin exhibits anti-tumor action in pituitary adenoma cells via Ras/ERKs and ROS-dependent mitochondrial signaling pathways. Journal of Pharmacy and Pharmacology 2014;66(3):408-417. doi: 10.1111/jphp.12170.
  85. Wang D, Tan QR, Zhang ZJ*. Neuroprotective effects of paeoniflorin, but not the isomer albiflorin, are associated with the suppression of intracellular calcium and calcium/calmodulin protein kinase II in PC12 cells. Journal of Molecular Neurosciences 2013;51(2):581-590. DOI 10.1007/s12031-013-0031-7
  86. Ma CH, Ling LW, Leung LS, Cai XY, Vivian Wong VTCW, Ziea ETC, Zhang ZJ*. Chinese herbal medicine for benign prostatic hyperplasia: systematic review and meta-analysis. Asian Journal of Andrology 2013;15:471-482.
  87. Wang D, Wong, HK, Feng YB, Zhang ZJ*. Peoniflorin, a natural neuroprotective agent, modulates multiple anti-apoptotic and apoptotic pathways in differentiated PC12 cells. Cellular and Molecular Neurobiology 2013;33:521–529.
  88. Zhong LLD, Tong Y, Tang GWK, Zhang ZJ, Choi WK, Lok CK, Sze SCW, Kun W, Liu Q, Yu BXB. A randomized double-blinded controlled trial of a Chinese herbal formula (Er-Xian Decoction) for menopausal symptoms in Hong Kong perimenopausal women. Menopause 2013;20:767-776.
  89. Wang N, Zhu M, Tsao SW, Man K, Zhang ZJ, Feng Y. Up-regulation of TIMP-1 by genipin inhibits MMP-2 activities and suppresses the metastatic potential of human hepatocellular carcinoma. PLoS One. 2012;7(9):e46318.
  90. Wang D, Wong HK, Zhang L, McAlonan GM, Wang XM, Sze SCW, Feng YB, Zhang ZJ*. Not only dopamine D2 receptors involved in Peony-Glycyrrhiza Decoction, an herbal preparation against antipsychotic-associated hyperprolactinemia. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2012;39(2):332-338.
  91. Sze SC, Cheung HP, Ng TB, Zhang ZJ, Wong KL, Wong HK, Hu YM, Yow CM, Tong Y. Effects of Erxian decoction, a Chinese medicinal formulation, on serum lipid profile in a rat model of menopause. Chinese Medicine 2011;6(1):40.
  92. Qin F, Wu XA, Tang Y, Huang Q, Zhang ZJ, Yuan JH. Meta-analysis of randomized controlled trials to assess the effectiveness and safety of Free and Easy Wanderer Plus, a polyherbal preparation for depressive disorders. Journal of Psychiatric Research 2011; 45:1518-1524.
  93. Zhang ZJ*, Tan QR, Tong Y, Wang XY, Wang HH, Ho LM, Wong  HK, Feng YB, Wang D, Ng R, McAlonan GM, Wang CY, Wong VT. An epidemiological study of the concomitant use of Chinese medicine and antipsychotics in schizophrenic patients: implication for herb-drug interaction. PLoS ONE 2011;6(2): e17239. doi:10.1371/journal.pone.0017239.
  94. Gao M, Chu HY, Jin GZ, Zhang ZJ, Wu J, Zhen XC. l-Stepholidine-induced excitation of dopamine neurons in rat ventral tegmental area is associated with its 5-HT(1A) receptor partial agonistic activity. Synapse 2011;65:379-387.
  95. Lin X, Sze SCW, Tong Y, Zhang ZJ, Feng YB, Chen JP, Ng TB, Lin X, Shaw PC,  Zhang KYB. Protective effect of Dendrobium officinale polysaccharides on experimental Sjogren’s Syndrome. Journal of Complementary and Integrative Medicine 2010;7(1): Article 14. DOI: 10.2202/1553-3840.1342.
  96. Wang HN, Peng Y, Tan QR, Wang HH, Chen YC, Zhang RG, Wang ZZ, Guo L, Liu Y, Zhang ZJ*. Free and Easy Wanderer Plus (FEWP), a polyherbal preparation, ameliorates PTSD-like behavior and cognitive impairments in stressed rats. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2009;33:1458-1463.
  97. Sze SCW, Tong Y, Zhang YB, Zhang ZJ, Lau ASL, Wong HK, Tsang KW, Ng TB. A novel mechanism: Erxian Decoction, a Chinese medicine formula, for relieving menopausal syndrome. Journal of Ethnopharmacology 2009;123(1):27-33.
  98. Zhang ZJ, Tong Y. Zou J, Chen PJ, Yu DH. Dietary supplement with a combination of Rhodiola crenulata and Ginkgo biloba enhances endurance performance in healthy volunteers. Chinese Journal of Integrative Medicine 2009;15(3):177-183.
  99. Yuan HN, Wang CY, Sze CH, Tong Y, Tan QR, Feng XJ, Liu RM, Zhang JZ, Zhang YB, Zhang ZJ*. A randomized crossover comparison of herbal medicine and bromocriptine against risperidone-induced hyperprolactinemia in patients with schizophrenia. Journal of Clinical Psychopharmacology 2008;28:264-270.
  100. Zhang ZJ*, Kang WH, Li Q, Tan QR. The beneficial effects of the herbal medicine Free and Easy Wanderer Plus (FEWP) for mood disorders: double-blind, placebo-controlled studies. Journal of Psychiatric Research 2007;41:828-836.
  101. Zhang ZJ*, Tong Y, Wang XY, Yao SM, Jin GX. Huperzine A as add-on therapy in patients with treatment-resistant schizophrenia: an open-labeled trial. Schizophrenia Research 2007;92:273-275.
  102. Zhang ZJ*, Kang WH, Tan QR, Li Q, Gao CG, Zhang FG, Wang HH, Ma XC, Chen C, Wang W, Guo L, Zhang YH, Yang XB, Yang GD. Adjunctive herbal medicine with carbamazepine for bipolar disorders: A double-blind, randomized, placebo-controlled study. Journal of Psychiatric Research 2007;41:360-369.
  103. Zhang ZJ*. Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders (review). Life Sciences 2004;75:1659-1699.
  104. Zhang ZJ*, Qian YH, Hu HT, Yang J, Yang GD. The herbal medicine Dipsacus asper Wall extract reduces the cognitive deficits and overexpression of beta-amyloid protein induced by aluminum exposure. Life Sciences 2003;73:2443-2454.
  105. Traditional Chinese medicine theory
  106. Liu LY, Xu XP, Luo LY, Zhu CQ, Li YP, Wang PR, Zhang YY, Yang CY, Hou HT, Cao YL, Wang G, Hui ES, Zhang ZJ*. Brain connectomic associations with traditional Chinese medicine diagnostic classification of major depressive disorder: a diffusion tensor imaging study. Chinese Medicine 2019;14:15.
  107. Kam W, Zhang ZJ, Bäärnhielm S. Traditional Chinese Medicine Explanatory Models of Depressive Disorders: A Qualitative Study. Cult Med Psychiatry. 2019 Apr 8. doi: 10.1007/s11013-019-09628-7. [Epub ahead of print]
  108. Liu LY, Zhang HJ, Luo LY, Pu JB, Liang WQ, Zhu CQ, Li YP, Wang PR, Zhang YY, Yang CY, Zhang ZJ*. Blood and urinary metabolomic evidence validating traditional Chinese medicine diagnostic classification of major depressive disorder. Chinese Med. 2018;13:53.
  109. Wong W, Lam CLK, Bian Z, Zhang ZJ, Ng SN, Tung S. Morbidity pattern of traditional Chinese medicine primary care in the Hong Kong population. Scientific Reports 2017;7: 7513.
  110. Hsu WWQ, Chan EWY, Zhang ZJ, Bian ZX, Lin ZS, Hsia YF, Wong ICK. A survey to investigate attitudes and perceptions of Chinese medicine professionals in health information technology in Hong Kong: a survey study to investigate attitudes and perceptions of Chinese medicine professionals in health information technology in Hong Kong. European Journal of Integrative Medicine 2015;7:36-46.
  111. Hsu WWQ, Zhang ZJ, Bian ZX, Lin ZS, Wong I. Chinese medicine students' views on electronic prescribing: a survey study in Hong Kong. European Journal of Integrative Medicine. European Journal of Integrative Medicine 2015;7(1):47-54.
  112. Psychopharmacology, psychiatry, and neuroscience
  113. Wang HH, Cai M, Wang HN, Chen YC, Zhang RG, Wang Y, McAlonan GM, Bai YH, Wu WJ, Guo L, Zhang YH, Tan QR, Zhang ZJ*. An assessor-blinded, randomized comparison of efficacy and tolerability of switching from olanzapine to ziprasidone and the combination of both in schizophrenia spectrum disorders. Journal of Psychiatric Research, 2017;85:59-65.
  114. Wang XM, Walitt B, Saligan LN, Brell JM, Tiwari A, Zhang ZJ. Chemobrain: a critical review and causal hypothesis of link between cytokines and epigenetic reprogramming associated with chemotherapy. Cytokine 2015;72:86–96.
  115. Zhang ZJ*, Wang D, Man SC, Ng R, McAlonan GM, Wong HK, Wong W, Lee J, Tan QR. Platelet 5-HT1A receptor correlates with major depressive disorder in drug-free patients. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2014; 53:74-79.
  116. Jiang X, Zhang ZJ, Zhang S, Gamble EH, Jia M, Ursano RJ, Li H. 5-HT2A receptor antagonism by MDL 11,939 during inescapable stress prevents subsequent exaggeration of acoustic startle response and reduced body weight in rats. Journal of Psychopharmacology 2011;25:289-297.
  117. Wang HH, Zhang ZJ*, Tan QR, Yin H, Chen YC, Wang HN, Zhang RG, Wang ZZ, Guo L, Tang LH, Li LJ. Psychopathological, biological, and neuroimaging characterization of posttraumatic stress disorder in survivors of a severe coalmining disaster in China. Journal of Psychiatric Research 2010;44:385-392.
  118. Wang HN, Peng Y, Tan QR, Chen YC, Zhang RG, Qiao YT, Wang HH, Liu L, Kuang F, Wang BR, Zhang ZJ*. Quetiapine ameliorates PTSD-like behavior and cognitive impairments in stressed rats: implications for the treatment of posttraumatic stress disorder. Physiological Research 2010;59:263-271.
  119. Zhang ZJ*, Tan QR, Tong Y, Kang WH, Li Q, Zhen XC, Post RM. The effectiveness of carbamazepine in unipolar depression: a double-blind, randomized, placebo-controlled study. Journal of Affective Disorders 2008;109:91-97.
  120. Yu Y, Wang JR, Sun PH, Guo Y, Zhang ZJ, Jin GZ, Zhen X. Neuroprotective effects of atypical D(1) receptor agonist SKF83959 are mediated via D(1) receptor-dependent inhibition of glycogen synthase kinase-3beta and a receptor-independent anti-oxidative action. Journal of Neurochemistry 2008;104:946-956.
  121. Tan QR, Wang XZ, Wang CY, Liu XJ, Chen YC, Wang HH, Zhang RG, Zhen XC, Tong Y, Zhang ZJ*. Differential effects of classical and atypical antipsychotic drugs on rotenone-induced neurotoxicity in PC12 cells. European Neuropsychopharmacology 2007;17:768-773.
  122. Zhang ZJ*, Kang WH, Li Q, Wang XY, Yao SM, Ma AQ. Beneficial effects of ondansetron as an adjunct to haloperidol for chronic, treatment-resistant schizophrenia: a double-blind, randomized, placebo-controlled study. Schizophrenia Research 2006;88: 102-110.
  123. Xu JH, Hu HT, Liu Y, Qian YH, Liu ZH, Zhang ZJ*. Neuroprotective effects ebselen are associated with alterations in the expression of Bcl-2 and Bax in cultured rat cortical neurons. Neuroscience Letters 2006;399:210-214.
  124. Xiang YQ, Zhang ZJ*, Weng YZ, Zhai YM, Li WB, Cai ZJ, Tan QR, Wang CY. Serum concentrations of clozapine and norclozapine in the prediction of relapse of patients with schizophrenia. Schizophrenia Research 2006;83:201-210.
  125. Zhang ZJ*, Li Q, Kang WH, Tan QR, Gao CG, Zhang FG, Wang HH, Ma XC, Chen C, Wang W,  Guo L, Zhang YH, Yang XB, Zhang RG. Differences in hypothyroidism between lithium-free and –treated patients with bipolar disorders. Life Sciences 2006;78:771-776.
  126. Zhang ZJ*, Jiang XL, Zhang SE, Zhang Y, Li H, Chen JG, Zhen XC. The paradoxical effects of SKF83959, a novel dopamine D1-like receptor agonist, in the rat acoustic startle reflex test. Neuroscience Letters 2005;382:134-138.
  127. Wang CY, Zhang ZJ*, Li WB, Zhai YM, Cai ZJ, Weng YZ, Zhu RH, Zhao JP, Zhou HH. The differential effects of steady-State fluvoxamine on pharmacokinetics of olanzapine and clozapine in healthy volunteers. Journal of Clinical Pharmacology 2004;44:785-792.
  128. Zhang ZJ*, Xing GQ, Russell S, Obeng K, Post RM. Unidirectional cross-tolerance from levetiracetam to carbamazepine in amygdala-kindled seizures. Epilepsia 2003; 44:1487-1493.
  129. Zhang ZJ*, Russell S, Postma T, Obeng K, Obrocea G, Weiss SR, Post RM, Coadministration of gabapentin or MK-801 with lamotrigine slows tolerance to its anticonvulsant effects on kindled seizures. Pharmacology Biochemistry and Behavior 2003;74:565-571.
  130. Zhang ZJ*, Postma T, Obeng K, Russell S, Weiss SR, Post RM, The benzodiazepine partial inverse agonist Ro15-4513 alters anticonvulsant and lethal effects of carbamazepine in amygdala-kindled rats. Neuroscience Letters 2002;329:253-256.
  131. Wang XM, Zhang ZJ, Bains R, Mokha SS. Antisense knockdown of the 2A-adrenoceptor reduces the antinociceptive effect of clonidine on the NMDA-induced nociceptive behavioral responses. Pain 2002;98:27-35.
  132. Zhang ZJ, Trivedi BL, de Paulis T, Mack JL, Schmidt DE, Hewlett WA, Discrimination in 5-HT-3 receptor binding in murine brain and cultured cell preparations. Naunyn-Schmiedeberg's Archives of Pharmacology 2002;365:23-132.
  133. Zhang ZJ, Schmidt DE, de Paulis T, Trivedi BL, Onaivi ES, Ebert MH, Hewlett WA, Anxiolytic- like effects of DAIZAC, a selective high-affinity 5-HT3 receptor antagonist, in the mouse elevated plus-maze. Pharmacology Biochemistry and Behavior 2001;69: 571-578.
  134. Hewlett WA, Trivedi BL, Zhang ZJ, de Paulis T, Schmidt DE, Lovinger DM, Ansari MS, Ebert MH, Characterization of (S)-des-4-amino-3-125I iodozacopride ([125I]DAIZAC), a selective high-affinity radioligand for 5-HT-3 receptors, Journal of Pharmacology and Experimental Therapeutics 1999;288:221-231.
  135. Zhang ZJ, Lappi DA, Wrenn CC, Milner TA, Wiley RG. Selective lesion of the cholinergic basal forebrain causes a loss of cortical neuropeptide Y and somatostatin neurons. Brain Research 1998; 800: 198-206.
  136. Hewlett WA, de Paulis T, Mason NS, Schmidt DE, Trivedi BL, Zhang ZJ, Ebert MH. Synthesis and radioiodination of (S)-4-amino-5-iodo-2 methoxy-N-(1-azabicyclo [2.2.2]oct-3-yl)benzamide, the active enantiomer of [125I] iodozacopride, and re-evaluation of its 5-HT-3 receptor affinity, Chemical & Pharmaceutical Bulletin 1997;45;2079-2084.
  137. Zhang ZJ, Berbos TG, Wrenn CC, Wiley RG, Loss of nucleus basalis magnocellularis, but not septal, cholinergic neurons correlates with passive avoidance impairment in rats treated with 192-saporin. Neuroscience Letters 1996;203:214-218.
  138. de Paulis T, Trivedi BL, Zhang ZJ, Schmidt DE, Mason NS, Ebert MH, Hewlett WA. (S)-4-amino-5- chloro-3-iodo-2-methoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamide (TRIZAC), a high affinity ligand for the 5-HT3 receptor. Bioorganic & Medicinal Chemistry Letters 1996;6:2657-2662.