2018.10 - 2022.12	Ph.D., School of Chinese Medicine, Faculty of Medicine, the University of Hong Kong
2014.09 - 2018.01	M.Sc., Biochemistry and molecular biology, Fudan University, Shanghai
2010.09 - 2014.07	B.Sc., Department of Nutrition; School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai

2025 Sep – present	Chair, Early Career Researcher Committee, Society for Free Radical Research Asia (SFRR Asia)
2025 Sep – present	Council Member, Redox Biology and Medicine Division, Chinese Society for Biophysics
2022 Jul – present	Council Member, Board of Specialty Committee of State target Strategy, World Federation of Chinese Medicine Societies

2025.10 - present	Research Assistant Professor, School of Chinese Medicine, Faculty of Medicine, The University of Hong Kong
2023.07 - 2025.10	Postdoctoral Fellow, School of Chinese Medicine, Faculty of Medicine, The University of Hong Kong

1. Discovery of bioactive compounds and pharmacological mechanisms of traditional Chinese medicines
2. Exploration of redox biology and free radical signaling in cellular regulation
3. Investigation of strategies targeting redox regulation for the prevention and treatment of stroke and neuroimmune disorders

1. Travel Award, The 22nd Biennial Meeting of Society for Free Radical Research-International, June 3-6, 2025, Galway, Ireland.
2. Invited Speaker, The 11th Meeting of the Society for Free Radical Research-Asia, Oct. 2, 2024, Beijing.
3. Outstanding award of the poster presentation; Chinese Conference on Redox Biology & Medicine, Aug 2023, Xiamen.
4. Youth Outstanding Thesis Award of the Oral presentation; The International Postgraduate Symposium on Chinese Medicine, Aug 2021, Hong Kong.
5. Outstanding award of the poster presentation; The International Postgraduate Symposium on Chinese Medicine, Aug 2019, Hong Kong, China.
6. Outstanding award of the poster presentation; Postgraduate Symposium on Biomedical Science; Dec 2017; Shanghai.
7. Gold award of the poster presentation; Global Chinese Symposium & The 7th Symposium for Cross-straits, Hong Kong & Macao on Free Radical Biology & Medicine; 2016; Taiwan.
8. 2017 National Postgraduate Scholarship, Ministry of Education, China.

Books and Book chapters:

1. Editorial Member in Mitochondrial Biomedicine: Targeting Mitochondrial Function to Prevent and Treat Major Human Diseases — "Mitochondria and Metabolism", Xi'an Jiaotong University Press, Editor-in-Chief by Liu J & Shen W; 2024, ISBN: 9787569337631 (Selected for inclusion in China's "13th Five-Year" National Key Book Publishing Program; in Chinese)
2. Editorial Member in Mitochondrial Biomedicine: Targeting Mitochondrial Function to Prevent and Treat Major Human Diseases — "Mitochondrial Research Methodology", Xi'an Jiaotong University Press, Editor-in-Chief by Liu H & Shi D; 2024, ISBN: 978-7-5693-2021-3 (Selected for inclusion in China's "13th Five-Year" National Key Book Publishing Program; in Chinese)
3. YU S., WU M., FENG Y., SHEN J., LU L., and LIN X., Detection of T follicular helper cells and T follicular regulatory cells in experimental Sjögren’s syndrome. T-Follicular Helper Cells: Methods and Protocols, 2022: p. 211-224. (Book chapter)

Peer-reviewed Journal Articles

Representative publications (first/co-first author)

1. YU S., WU M., ZENG W., FU W., CHEN Y., XIE J., LI H., FENG Y., SHEN J. and LIN X., Caveolin-1/PPARα axis suppresses T follicular helper cell response in primary Sjögren’s disease. Cell reports. 2025 (co-first author)
2. YU S, WU M., SHEN, J. and LIN X, Calycosin synergizes with methotrexate in the treatment of Sjögren’s disease by targeting BATF in T follicular helper cells. Acta Pharmacologica Sinica. 2025. (co-first author)
3. WU M., YU S., YAN S., WU M., ZHANG L., CHEN S., SHI D., LIU S., FAN Y., LIN X., and SHEN J. Peroxynitrite reduces Treg cell expansion and function by mediating IL-2R nitration and aggravates multiple sclerosis pathogenesis. Redox Biology, 2024: p. 103240.
4. LI W., WU M., LI Y., and SHEN J., Reactive nitrogen species as therapeutic targets for autophagy/mitophagy modulation to relieve neurodegeneration in multiple sclerosis: Potential application for drug discovery. Free Radical Biology and Medicine, 2023. (co-first author)
5. WU M., ZHAO A., YAN X., GAO H., ZHANG C., LIU X., LUO Q., XIE F., LIU S., and SHI D., Hepatic AMPK signaling dynamic activation in response to REDOX balance are sentinel biomarkers of exercise and antioxidant intervention to improve blood glucose control. Elife, 2022, 11: p. e79939.
6. YE S., YANG B., WU M. , CHEN Z., SHEN J., SHABAT D., and YANG D., Recurring real-time monitoring of inflammations in living mice with a chemiluminescent probe for hypochlorous acid. CCS Chemistry, 2022, 4(6): p. 1871-1878. (co-first author)
7. GAO C., WU M., DU Q., DENG J., and SHEN J., Naringin mediates adult hippocampal neurogenesis for antidepression via activating CREB signaling. Frontiers in cell and developmental biology, 2022, 10: p. 731831. (co-first author)
8. WU M., ZHANG C., XIE M., ZHEN Y., LAI B., LIU J., QIAO L., LIU S., and SHI D., Compartmentally scavenging hepatic oxidants through AMPK/SIRT3-PGC1α axis improves mitochondrial biogenesis and glucose catabolism. Free Radical Biology and Medicine, 2021, 168: p. 117-128.
9. WU M., LIAO L., JIANG L., ZHANG C., GAO H., QIAO L., LIU S., and SHI D., Liver-targeted Nano-MitoPBN normalizes glucose metabolism by improving mitochondrial redox balance. Biomaterials, 2019, 222: p. 119457.
10. WU M., YU S., CHEN Y., MENG W., CHEN H., HE J., SHEN J., and LIN X., Acteoside promotes B cell-derived IL-10 production and ameliorates autoimmunity. Journal of Leukocyte Biology, 2022, 112(4): p. 875-885.
11. WU M. and SHI D., Reactive Oxygen Species-Mediated Glucose Metabolic Reprogram Induces Insulin Resistance in Type 2 Diabetes. Free Radical Biology and Medicine, 2016, 100: p. S178.
12. DONG K., WU M. *, LIU X., HUANG Y., ZHANG D., WANG Y., YAN L.-J., and SHI D., Glutaredoxins concomitant with optimal ROS activate AMPK through S-glutathionylation to improve glucose metabolism in type 2 diabetes. Free Radical Biology and Medicine, 2016, 101: p. 334-347. (co-first author)
13. WU M, ZHAO A, XIE F, LIU S, SHI D. 2013. The Mechanism of Huo Xue Hua Yu Chinese Medicine and its Relationship with Antioxidant Activity. Journal of Biochemical and Pharmacological Research

Collaborative publications (Selected)

1. DU Q., LIANG R., WU M., YANG M., XIE Y., LIU Q., TANG K., LIN X., YUAN S., and SHEN J., Alisol B 23-acetate broadly inhibits coronavirus through blocking virus entry and suppresses proinflammatory T cells responses for the treatment of COVID-19. Journal of Advanced Research, 2024, 62:p. 273-290.
2. DU Q., GAO C., TSOI B., WU M., and SHEN J., Niuhuang Qingxin Wan ameliorates depressive-like behaviors and improves hippocampal neurogenesis through modulating TrkB/ERK/CREB signaling pathway in chronic restraint stress or corticosterone challenge mice. Frontiers in Pharmacology, 2024, 14:p. 1274343.
3. CHEN Y., XIE J., WU M., YU S., SHEN J., and LIN X., Ginseng-Epimedii formula ameliorated experimental Sjögren’s syndrome via reducing IL-6 production. Journal of Functional Foods, 2024, 116:p. 106198.
4. CHEN S., PAN J., GONG Z., WU M., ZHANG X., CHEN H., YANG D., QI S., PENG Y., and SHEN J., Hypochlorous acid derived from microglial myeloperoxidase could mediate high-mobility group box 1 release from neurons to amplify brain damage in cerebral ischemia–reperfusion injury. Journal of Neuroinflammation, 2024, 21(1): p. 70.
5. CHEN Y., FU W., ZHENG Y., YANG J., LIU Y., QI Z., WU M., FAN Z., YIN K., and CHEN Y., Galectin 3 enhances platelet aggregation and thrombosis via Dectin-1 activation: a translational study. European Heart Journal, 2022, 43(37): p. 3556-3574.
6. XIE F., WU M., LAI B., HALIM M., LIU S., and SHI D., Effects of redox interference on the pancreatic mitochondria and the abnormal blood glucose. Free Radical Research, 2021, 55(2): p. 119-130.
7. WEN Y., CHEN H., ZHANG L., WU M., ZHANG F., YANG D., SHEN J., and CHEN J., Glycyrrhetinic acid induces oxidative/nitrative stress and drives ferroptosis through activating NADPH oxidases and iNOS, and depriving glutathione in triple-negative breast cancer cells. Free Radical Biology and Medicine, 2021, 173:p. 41-51.
8. CHEN J., ZHANG L., WU M., and SHEN J., Active compounds combination ameliorates CFA-induced inflammatory model by attenuating macrophage-mediated localized response and nitrative damage. Free Radical Biology and Medicine, 2021, 165:p. 26-59.
9. ZHANG Y., HE Y., WU M., CHEN H., ZHANG L., YANG D., WANG Q., and SHEN J., Rehmapicroside ameliorates cerebral ischemia-reperfusion injury via attenuating peroxynitrite-mediated mitophagy activation. Free Radical Biology and Medicine, 2020, 160:p. 526-539.
10. LI Y., ZHAO Y., GAO C., WU M., SO K.-F., TONG Y., and SHEN J., Caveolin-1 derived from brain microvascular endothelial cells inhibits neuronal differentiation of neural stem/progenitor cells in vivo and in vitro. Neuroscience, 2020, 448:p. 172-190.
11. LI W., FENG J., GAO C., WU M., DU Q., TSOI B., WANG Q., YANG D., and SHEN J., Nitration of Drp1 provokes mitophagy activation mediating neuronal injury in experimental autoimmune encephalomyelitis. Free Radical Biology & Medicine, 2019, 143:p.70-83.
12. JIANG L., CHEN Q., WU M., JI T., LIU S., ZHU F., and SHI D., Short-term high salt intake impairs hepatic mitochondrial bioenergetics and biosynthesis in SIRT3 knockout mice. Free Radical Research, 2019, 53(4): p. 387-396.
13. ZHANG K., WANG Y., WU M., LIU Y., SHI D., and LIU B., On-demand quantitative SERS bioassays facilitated by surface-tethered ratiometric probes. Chemical Science, 2018, 9(42): p. 8089-8093.
14. HUANG R., ZHANG D., LI F., XIAO Z., WU M., SHI D., XIANG P., and BAO Z., Loss of Fas expression and high expression of HLA-E promoting the immune escape of early colorectal cancer cells. Oncology Letters, 2017, 13(5): p. 3379-3386.
15. LI P., ZHANG D., SHEN L., DONG K., WU M., OU Z., and SHI D., Redox homeostasis protects mitochondria through accelerating ROS conversion to enhance hypoxia resistance in cancer cells. Scientific reports, 2016, 6(1): p. 22831.
16. LI P., WU M., WANG J., SUI Y., LIU S., and SHI D., NAC selectively inhibit cancer telomerase activity: A higher redox homeostasis threshold exists in cancer cells. Redox biology, 2016, 8:p. 91-97.
17. DONG K., NI H., WU M., TANG Z., HALIM M., and SHI D., ROS-mediated glucose metabolic reprogram induces insulin resistance in type 2 diabetes. Biochemical and biophysical research communications, 2016, 476(4): p. 204-211.