Professoriate Staff

Professor Xiang LIN
Assistant Professor,
School of Chinese Medicine,
Li Ka Shing Faculty of Medicine,
The University of Hong Kong
SPOKEN LANGUAGES

Cantonese, Mandarin and English

WRITTEN LANGUAGES

Chinese and English

ACADEMIC QUALIFICATION
Jan 2008 – May 2012 PhD, School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Sept 2003 – Jul 2007 Bachelor of Science, Department of Chinese Medicines, China Pharmaceutical University, Nanjing, China
CURRENT PROFESSIONAL SERVICES
2022 - Present Regular Member, The American Association of Immunologists
2021 - Present Affiliated Investigator, the State Key Laboratory of Pharmaceutical Biotechnology, the University of Hong Kong
2020 - 2022 Hon Secretary, Hong Kong Society of Flow Cytometry, Hong Kong
2015 - 2016 Assistant Secretary, Hong Kong Society for Immunology, Hong Kong
2014 - 2015 Hon Secretary, Hong Kong Society of Flow Cytometry, Hong Kong
WORK EXPERIENCE
Oct 2019 - Present Assistant Professor, School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Feb 2013 – Sept 2019 Post-doctoral Fellow, Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Jun 2012 – Jan 2013 Research Assistant, Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
RESEARCH INTEREST AND ACHIEVEMENT

Research Grants

Sep 2022 – Aug 2024 Principle Investigator
Targeting peroxisome proliferator-activated receptors in the treatment of Sjögren’s syndrome
(Health and Medical Research Fund, 19201121, on-going)
Jan 2022 – Dec 2024 Principle Investigator
Role of Caveolin-1 in regulating T cell responses in primary Sjogren’s syndrome
(General Research Fund, 17116521, on-going)
Jan 2021 – Dec 2023 Principle Investigator
Novel Therapeutic Strategy for Sjogren’s Syndrome: Targeting Myeloid-Derived Suppressor Cells
(General Research Fund, No. 27111820), on-going
Apr 2020 – Apr 2021 Principle Investigator
Heat-cooling Chinese herbs in treating chronic hepatitis B patients comparing with antiviral therapy: A systematic review and network meta-analysis (Health and Medical Research Fund, 17181101, completed)
Jan 2014 – Dec 2016 Principle Investigator
Regulation of experimental Sjögren’s syndrome by Th17 cells
(National Natural Science Foundation of China, 31300739, completed)

Research Awards

2022 Society for Leukocyte Biology Image Contest
2021 Gold medal, QS Reimagine Education Award
2021 Best Oral Presentation, Innovating Drug Immunology Summit
2019 Young Investigator Award, the Hong Kong Society for Immunology
2018 Best Poster Presentation Award, the Hong Kong Society for Immunology
2017 Chinese Medical Science and Technology Awards (201702008)
2016 Best Poster Presentation Award, the Hong Kong Society for Immunology
2016 Beijing Science and Technology Award (2015 醫-2-006)
2015 Outstanding Presentation of Young Investigator, Hong Kong-France Symposium on Transplantation & Cancer Immunology, Institut National de la Santé et de la Recherche Médicale (Inserm), France, and HKU
2014 Croucher Summer Course Scholarship in Immunology
2014 Best Oral Presentation Award, the Hong Kong Society of Flow Cytometry
2014 Best Poster Presentation Award, the Hong Kong Society for Immunology
2013 Honor of Individual Award of Shenzhen Virtual University Park for National Research Project

Editorial Board Member

  • 1. Journal of Leukocyte Biology, Section Editor
  • 2. Immunology Letters, Review Editor
  • 3. Frontiers of Pharmacology, Review Editor
  • 4. Frontiers of Immunology, Guest Editor
SELECTED PUBLICATIONS

Selected Publications

  1. Wu M*, Yu S*, Chen Y, Meng W, Chen H, He J, Shen J#, Lin X#. Acteoside promotes B cell-derived IL-10 production and ameliorates autoimmunity. Journal of Leukocyte Biology (DOI: 10.1002/JLB.3MA0422-510R, Impact factor: 6.0)  
  2. Wang X, Lin X, Zheng Z, Lu B, Wang J, Tan AH, Zhao M, Loh JT, Ng SW, Chen Q, Xiao F, Huang E1, Ko KH, Huang Z, Li J, Kok KH, Lu G, Liu X, Lam KP, Liu W, Zhang Y, Yuen KY, Mak TW, Lu L. Host- derived lipids orchestrate pulmonary γδ T cell response to provide early protection against influenza virus infection. Nature Communications. 2021, 12: 1914. (Impact factor: 17.69)
  3. Yu H, Wu W, Lin X and Feng Y. Polysaccharide-Based Nanomaterials for Ocular Drug Delivery: A Perspective. Frontiers in Bioengineering and Biotechnology. 2020, 8:601246. (Impact factor: 6.06)
  4. Lin X, Wang X, Xiao F, Ma K, Liu L, Xu D, Wang F, Shi X, Zhao Y, Liu D, Lu L. IL-10-producing regulatory B cells restrain the T follicular helper cell response in primary Sjögren’s syndrome. Cellular & Molecular Immunology. 2019, 16: 921-931. (Impact factor: 22.09)
  5. Wang X, Ye C, Lin X, Ma K, Xiao F, Li L, Lu L. New insights into the significance of the BCR repertoire in B-1 cell development and function. Cellular & Molecular Immunology. 2019, 16(9): 772-773. (Impact factor: 22.09)
  6. Ma K, Wang X, Shi X, Lin X, Xiao F, Ma X, Liu D, Lu L. The expanding functional diversity of plasma cells in immunity and inflammation. Cellular & Molecular Immunology. 2019, doi: 10.1038/s41423-019-0308-z (Impact factor: 27.97)
  7. Tian J, Rui K, Hong Y, Wang X, Xiao F, Lin X, Ma J, Guo H, Xu H, Ma K, Xu D, Liu D, Zhao Y, Lu L, Wang S. Increased GITRL Impairs the Function of Myeloid-Derived Suppressor Cells and Exacerbates Primary Sjögren Syndrome. The Journal of Immunology. 2019, 15;202(6):1693-1703. (Impact factor: 5.42)
  8. Guggino G*, Lin X* (co-first author), Rizzo A, Xiao F, Saieva L, Liberto D, Candore G, Ruscitti P, Cipriani P, Giacomelli R, Dieli F, Alessandro R, Triolo G, #Lu L, #Francesco C. Interleukin-25 Axis Is Involved in the Pathogenesis of Human Primary and Experimental Murine Sjogren's Syndrome. Arthritis & Rheumatology. 2018, 70(8):1265-1275. (Impact factor: 15.48)
  9. Ma K, Li J, Wang X, Lin X, Du W, Yang X, Mou F, Fang Y, Zhao Y, Hong X, Chan KW, Zhang X, Liu D, Sun L, Lu L. TLR4(+)CXCR4(+) plasma cells drive nephritis development in systemic lupus erythematosus. Annals of the Rheumatic Diseases. 2018, 77:1498-1506. (Impact factor: 19.10)
  10. Fu W, Liu X, Lin X, Feng H, Sun L, Li S, Chen H, Tang H, Lu L, Jin W, Dong C. Deficiency in T follicular regulatory cells promotes autoimmunity. Journal of Experimental Medicine. 2018; 215(3):815-825. (Impact factor: 17.57).
  11. Rui K*, Lin X* (co-first author), Tian J, Wang X, Sun L, Hong X, Liu D, Wang S, Lu L. Ecto-mesenchymal stem cells: a new player for immune regulation and cell therapy. Cellular & Molecular Immunology. 2018, 15(1):82-84. (Impact factor: 22.09)
  12. Xiao F, Lin X, Tian J, Wang X, Chen Q, Rui K, Ma J, Wang S, Wang Q, Wang X, Liu D, Sun L, Lu L. Proteasome Inhibition Suppresses Th17 cell Generation and Ameliorates Autoimmune Development in Sjögren’s Syndrome. Cellular & Molecular Immunology. 2017, 14: 924–934. (Impact factor: 22.09)
  13. Lin X, Rui K, Deng J, Tian J, Wang X, Wang S, Ko KH, Jiao Z, Chan VS, Lau CS, Cao X, Lu L. Th17 cells play a critical role in the development of experimental Sjögren's syndrome. Annals of the Rheumatic Diseases. 2015, 74(6):1302-10. (Impact factor: 27.97)
  14. Rui K, Zhang Z, Tian J, Lin X, Wang X, Ma J, Tang X, Xu H, Lu L, Wang S. Olfactory ecto-mesenchymal stem cells possess immunoregulatory function and suppress autoimmune arthritis. Cellular & Molecular Immunology, 2016, 13(3):401-8. (Impact factor: 22.09)
  15. Lin X, Liu J, Chung W, Sze SC, Li H, Lao L, Zhang Y. Polysaccharides of Dendrobium officinale Induce Aquaporin 5 Translocation by Activating M3 Muscarinic Receptors. Planta medica. 2015, 81(2):130-137. (Impact factor: 3.00)
  16. Lin X, Tian J, Rui K, Ma KY, Ko KH, Wang S, Lu L. The role of T helper 17 cell subsets in Sjögren's syndrome: similarities and differences between mouse model and humans. Annals of the Rheumatic Diseases.2014, 73(7):e43. (Impact factor: 27.97)
  17. Lin X, Shaw PC, Sze CW, Tong Y, Zhang YB. Polysaccharides of Dendrobium Officinale inhibit TNF-α induced apoptosis in A-253 cell line. Inflammation Research. 2013 63 (3): 313-24 (Impact factor: 6.98)
  18. Lin X, Shaw PC, Sze SC, Tong Y, Zhang Y. Dendrobium officinale polysaccharides ameliorate the abnormality of aquaporin 5, pro-inflammatory cytokines and inhibit apoptosis in the experimental Sjögren's syndrome mice. International Immunopharmacology. 2011, 11 (12): 2025-32. (Impact factor: 5.71)
  19. Lin X, Song JX, Shaw PC, Ng TB, Sze CW, Tong Y, Lee KF, Zhang KY. An autoimmunized mouse model recapitulates key features in the pathogenesis of Sjögren's syndrome. International Immunology. 2011 23 (10): 613-624. (Impact factor: 5.07)
  20. Song JX, Lin X, Wong RNS, Sze SCW, Tong Y, Shaw PC, Zhang YB. Protective effects of dibenzocyclooctadiene lignans from Schisandra chinensis against beta‐amyloid and homocysteine neurotoxicity in PC12 cells. Phytotherapy Research. 2011, 25 (3), 435-443 (Impact factor: 6.38)

Other Publications

  1. Weifeng Wu, Xiao R Huang, Yongke You, Liang Xue, Xiao-Jing Wang, Xiaoming Meng, Xiang Lin, Jiangang Shen, Xueqing Yu, Hui-Yao Lan, Haiyong Chen. Latent TGF-b1 protects against diabetic kidney disease via Arkadia/Smad7 signaling. Int J Biol Sci 2021, 19;17(13):3583-3594. (Impact factor: 10.75; Q1)
  2. Fraide A Ganotice, Kelvin Kai Hin Fan, Zoe Lai Han Ng, Francis Hang Sang Tsoi, Abraham Ka Chung Wai, Alan Worsley, Xiang Lin, George L Tipoe. The short version of students' perceptions of interprofessional clinical education-revised (SPICE-R3): a confirmatory factor analysis. Journal of Interprofessional Care (Impact factor: 2.66; Q2)
  3. Shayi Wu*, Miao Chen*, Jiao Huang, Feifei Zhang, Zhaojie Lv, Yongxu Jia,2 Yu-Zhu Cui, Liang-Zhan Sun, Ying Wang, , Ying Tang, Krista R. Verhoeft, Yan Li, Yanru Qin, Xiang Lin, Xin-Yuan Guan#, Ka-On Lam#. ORAI2 Promotes Gastric Cancer Tumorigenicity and Metastasis Through PI3K/Akt Signaling and MAPK-dependent Focal Adhesion Disassembly. Cancer Research. 2020 DOI: 10.1158/0008-5472.CAN-20-0049. (Impact factor: 13.31 Q1)
  4. Zhao J Lyu, Ying Wang, Jin L Huang, Miao Chen, Sha Y Wu, Qian Yan, Yu Zhang, Ying Tang, Chen Jiang, Lei Li, Yi Z Jia, Yu C Liu, Hong B Mei, Feng Wang, Ren H Li, Ya C Chen, Xiang Lin, Zhi M Cai, Xin Y Guan. Recurrent ZNF83-E293V Mutation Promotes Bladder Cancer Progression through the NF-κB Pathway via Transcriptional Dysregulation of S100A8. Molecular Therapy. 2020 S1525-0016(20)30461-5. (Impact factor: 12.91; Q1)
  5. Chu H, Zhou J, Wong BH, Li C, Cheng ZS, Lin X, Poon VK, Sun T, Lau CC, Chan JF, To KK, Chan KH, Lu L, Zheng BJ, Yuen KY. Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response. Virology. 2014, 454-455:197-205. (Impact factor: 3.51; Q2)

CONFERENCE PAPERS

  1. Blocking of CD103+ tissue resident memory t cells (TRM) as a therapeutic strategy in Sjogren’s syndrome. Proceeding/Conference: Annals of the Rheumatic Diseases
  2. Novel function of IL-17E in the autoimmune pathogenesis of experimental Sjogren´s syndrome Proceeding/Conference: European Journal of Immunology
  3. Polysaccharides from dendrobium officinale ameliorate murine Sjögren's syndrome development via modulating immune responses. Proceeding/Conference:7th Federation of Immunological Societies of Asia-Oceania Congress (FIMSA 2018)
  4. A Critical Role of Th17 Cells in the Development of Murine Sjogeren’s Syndrome. Proceeding/Conference: Journal of Immunology

BOOK CHAPTER

  1. Yu S, Wu M, Feng Y, Shen J, Lu L and Lin X. Detection of T follicular helper cells and T follicular regulatory cells in experimental Sjögren’s syndrome. Methods in Molecular Biology. Humana Press, New York, NY
  2. Lin X, Lu L. (2019) Chapter 13: B cell-mediated autoimmune diseases. B Cells in Immunity and Tolerance. Advances in Experimental Medicine and Biology. Springer Nature International Publishing AG. (United States)
  3. Lin X, Deng J, Lu L. (2014) IL-10 Detection in Murine B Cells: Pros and Cons of the Different Techniques. In: Vitale G., Mion F. (eds) Regulatory B Cells. Methods in Molecular Biology. Humana Press, New York, NY
  4. Lin X, Zhang Kalin YB (2009) Chapter 28-30, Basic and Clinical Toxicology of Chinese Medicine. Commercial Press (HK) Ltd. (Chinese).