Mandarin, English, Cantonese

Chinese Medicine and Integrative Medicine for Neurology, Cardiovascular Diseases and Oncology

Education

Postdoctoral and resident training

Academic Appointments

Hospital Appointments

Current Position

Vice Chairman

Executive Council Member

Honor Professorships

School of Chinese Medicine 2007-2021

MBBS, LKS Faculty of Medicine 2007-2021

School of Nursing, LKS Faculty of Medicine, 2011-2020

Common Core Curriculum Lectureship, 2012-2021

Hospital Authority, 2007- 2011

Traditional Chinese Medicine for treatments of cardiovascular diseases, cerebral vascular diseases, neurodegenerative diseases, insomnia and mental disorders, diabetes and metabolic syndrome, pancreatic cancer, gastrointestinal cancer, and brain cancer, etc.

Research Directions

1. Oxidative and redox signaling and inflammation in stroke and multiple sclerosis and therapeutic strategies of Chinese medicine
2. Stem cell and neurogenesis for post stroke treatment and Chinese medicine strategies
3. Artificial intelligence recognitions and its application in Traditional Chinese Medicine Diagnosis
4. Clinical investigations of Traditional Chinese Medicine for cardiovascular diseases, cerebral vascular diseases and cancer

Research Strategies

Integrating the approaches of basic science, translational medicine and clinical trials to developing novel diagnostic biomarkers and therapeutic agents.

Current Ongoing Highly Competitive Research Projects

1. Elucidating the roles of hypochlorous acid (HOCl) in mediating hemorrhage transformation (HT) in ischemic stroke with delayed thrombolytic therapy and its application for therapeutic approach with Acteoside. . RGC GRF grant No. 17105220, Hong Kong, HK$ 1,194,296; 2020.8-2023.7
2. Artificial intelligence recognitions for traditional Chinese medicine pulse patterns and its correlation study with body consititution in healthy human subjects. Health and Medical Research Fund, Hong Kong No. 1718811. HK$ 1,491,344.00, 2019.11-2022.10.
3. Chemical Biology Approach to Molecular Medicine. Areas of Excellence Scheme 2016/17, Research Grants Council AoE/P-705/16. HK$ 83,820,000 (with $78.077M from the RGC), Co-Principal Investigator, 2017-2023
4.   Development of critical technology and its application for industry translation: Focus on  Guangxi unique Jinhua Tea for anti-cancer, anti-inflammation and modulating gluocose-lipid metabolism. Guangxi Innovation Derived Development Specific Development Shame, Guangxi Science and Technology Bureau, Guangxi Province, China RMB 9,600,000,  Co-PI for anti-aging and anti-depression project, Allocation RMB 960,000, 2018.10-2020.9
5.   Exploring Molecular Targets for Drug Discovery to Preventing Hyperglycemia-mediated Hemorrhagic transformation in Ischemic Stroke: Sodium Danshensu (SDSS) as an Example. RGC GRF grant No. 17118717, HK$ 980,801 2017.10-2020.9

Completed Highly Competitive Research Projects

1.  Elucidating roles of reactive nitrogen species mediated excessive mitophagy in cerebral ischemia-reperfuision injury and protective effects of Naringin.  Grant from National Natural Science Foundation of China No. 31570855. RMB 620,000, 2016-2019
2. Evaluating the neuroprotective effect and safety of An-Gong-Niu-Huang Wan and its ingredients in ischemic stroke. Innovation and Technology Fund of Hong Kong, UICP Ref No. UIM/289. Hong Kong, HK$ 1,430,239; 2016.6-2018.5
3. Exploring Effects of Glycyrrhizin, an active compound from Glycyrrhizae Radix, on attenuating delayed tissue-plasminogen activator (t-PA) treatment-induced hemorrhagic transformation in Ischemic Stroke” HMRF Project Ref. No. 13142901, HK$ 1,009,  608,  2016.1-2019.12
4. Glycyrrhizin for protecting the blood brain barrier integrity and improving outcome.  Shenzhen Basic Research Sheme, Shenzhen Municipal Science and Technology Committee, Shenzhen, China,  SIRI/04/04/2015/06, RMB 300,000, 2016.1-2017.12
5. Exploring HMGB1 signaling as molecular target in peroxynitrite-mediated blood brain barrier disruption and hemorrhage transformation in ischemia-reperfused brain with delayed thrombolytic therapy. RGC GRF grant No. 17102915, Hong Kong, HK$ 738,179; 2016.1-2018.12
6. Exploring caveolin-1 as a novel molecular target for hampering T lymphocytes infiltration through blood brain barrier and attenuating disease progress in experimental autoimmune encephalomyelitis. RGC GRF grant No. 17118514, Hong Kong, HK$ 658,179; 2015.1-2017.12
7. Elucidating effects of APPL2 on regulating proliferation and cell fate decision of neural stem/progenitor cells through activating Notch signaling pathway. RGC GRF grant No. 777313, Hong Kong, HK$779,429; 2014.1-2016.12
8. Exploration of dietary compound isoliquiritigenin in chemosensitizing  breast cancer stem cells by targeting aberrant β-catenin signaling. HMRF Project 11121951, HK$ 758,360.00; 2013.9-2015.10
9. Molecular regulation of peroxynitrite for neurogenesis. Grant from National Natural Science Foundation of China. RMB 800,000; 2013.1-2015.12
10. Elucidating peroxynitrite as a cellular signaling molecule for regulating proliferation and neuronal differentiation of neural stem/progenitor cells under hypoxic and ischemic conditions. RGC GRF grant, Hong Kong, HK$ 1,158,250.00; 2012.9-2015.8
11. Effects of reactive nitrogen species inhibitors on preventing thrombolysis-induced blood brain barrier disruption and hemorrhagic transformation in cerebral ischemia-reperfusion injury. RGC GRF grant, Hong Kong, HK$ 890,000; 2011.9-2014.8    
12. Elucidating caveolin-1 as a negative modulating protein for proliferation and differentiation of neural stem/progenitor cells in post-ischemic brain.  RGC GRF grant, No. 777610M, Hong Kong, HK$1,084,600; 2010.9-2013.8
13. Interactions of reactive nitrogen species, caveolins and matrix metalloproteinases: A novel signal mechanism in disruption of blood brain barrier during ischemic stroke. RGC GRF grant No. 774408M, Hong Kong, HK$ 1,191,369; 2009.1-2011.12
14. Plasma membrane cholesterol homeostasis and oxidative stress: implication for neuronal oxidative damage in ischemia stroke. RGC Competitive Earmarked Research Grant No. 749504M, Hong Kong, HK$ 939,968; 2005.1-2007.12

Professor Shen is well recognized by international community in his research fields. He served as Chairman or Co-Chairman to organize 10 international conferences in Mainland China, Hong Kong, and Europe. He delivered over 150 lectures as keynote speakers, plenary speakers or invited speakers in international conferences. As Principal Investigator, he successfully bided 21 external highly competitive grants including RGC General Research Fund, Innovation and Technology Fund of Hong Kong, HMRF grant, National Natural Science Foundation of China, etc. As Co- Principal Investigator, he was awarded by the grant of Areas of Excellence Scheme 2016/17, Research Grants Council. His studies were also supported by many other donations, contract research projects and internal grants. He has published over 200 original articles and invited review articles in prestigious journals including Journal of Neuroscience, Free Radical Biology and Medicine, Journal of the American Chemical Society, Angewandte Chemie International Edition, Hepatology, Chemical Science , Journal of Cerebral Blood Flow and Metabolism, Translational Stroke Research, Frontiers in Cell and Developmental Biology, Nanotoxicology, Journal of Advanced Research, Toxicology and Applied Pharmacology, Neurobiology of Disease, , Neuropharmacology, Carcinogenesis, Journal of Ethnopharmacology, etc. Until March of 2021, his publications have been totally cited by 13423 times (Google citation) with Google H factor 46. Professor Shen was listed as 1% global high citation scientists by Clarivate (2019, 2020). He has published 16 books or book chapters. He received many scientific achievement awards.

Representative international publications (* Corresponding author)

1. Gu Y, Chen X, Fu S, Liu W, Wang Q, Liu KJ, Shen J*. Astragali Radix isoflavones synergistically alleviate cerebral ischemia and reperfusion injury via activating estrogen receptor-PI3K-Akt signaling pathway. Frontiers in Pharmacology 2021, 12: 132
2. Luo YX, Chen H, Tsoi B, Wang Q, Shen J*. Danggui-Shaoyao-San (DSS) ameliorates cerebral ischemia-reperfusion injury via activating SIRT1 signaling and inhibiting NADPH oxidases. Frontiers in Pharmacology 2021:12: 747
3. Chen H, Guan B, Chen S, Yang D, Shen J*. Peroxynitrite activates NLRP3 inflammasome and contributes to hemorrhagic transformation and poor outcome in ischemic stroke with hyperglycemia. Free Radical Biology and Medicine 2021; 165, 171-183
4. He Y, Chen S, Tsoi B, Qi S, Gu B, Wang Z, Peng C, Shen J*. Alpinia Oxyphlla Miq and its active compound P-coumaric acid promotes brain-derived neurotrophic factor signaling for inducing hippocampal neurogenesis and improving post cerebral ischemic spatial cognitive functions. Frontiers in Cell and Developmental Biology 2021; 8:577790. doi: 10.3389/fcell.2020.577790.
5. Li Y, Zhao Y, Gao C, Wu M, So KF, Tong Y, Shen J*. Caveolin-1 derived from brain microvascular endothelial cells inhibits neuronal differentiation of neural stem/progenitor cells in vivo and in vitro. Neuroscience2020; 448:172-190 (Impact Factor 3.056)
6. Chen X, Chen H, He Y, Fu S, Liu H, Wang Q, Shen J*. Proteomics-Guided Study on Buyang Huanwu Decoction for Its Neuroprotective and Neurogenic Mechanisms for Transient Ischemic Stroke: Involvements of EGFR/PI3K/Akt/Bad/14-3-3 and Jak2/Stat3/Cyclin D1 Signaling Cascades. Molecular Neurobiology 2020; 57(10): 4305-4321.
7. Chen H, Guan B, Wang B, Pu H, Bai X, Chen X, Liu J, Li C, Qiu J, Yang D, Liu K, Wang Q, Qi S, Shen J*. Glycyrrhizin Prevents Hemorrhagic Transformation and Improves Neurological Outcome in Ischemic Stroke with Delayed Thrombolysis Through Targeting Peroxynitrite-Mediated HMGB1 Signaling. Translational Stroke Research 2020;11(5):967-982
8. Zhang Y, He Y, Wu M, Chen H, Zhang L, Yang D, Wang Q, Shen J*. Rehmapicroside ameliorates cerebral ischemia-reperfusion injury via attenuating peroxynitrite-mediated mitophagy activation. Free Radical Biology and Medicine2020; 160:526-539
9. Gao C, Yan T, Chen X, Cheng KK, Xu A, Shen J*.  APPL2 negatively regulates olfactory functions by switching fate commitments of neural stem cells in adult olfactory bulb via interaction with notch1 signaling. Neuroscience Bulletin 2020;36(9):997-1008.  
10. Li W, Deng R, Jing X, Chen J, Yang D, Shen J*. Acteoside ameliorates experimental autoimmune encephalomyelitis through inhibiting peroxynitrite-mediated mitophagy activation. Free Radical Biology and Medicine 2020 ; 146:79-91
11. Li W, Feng J, Gao C, Wu M, Du Q, Tsoi B, Wang Q, Yang D, Shen J*. Nitration of Drp1 provokes mitophagy activation mediating neuronal injury in experimental autoimmune encephalomyelitis. Free Radical Biology and Medicine 2019; 143: 70-83
12. Tsoi B, Wang S, Gao C, Luo Y, Li W, Yang D, Yang D, Shen J*. Realgar and cinnabar are essential components contributing to neuroprotection of Angong Niuhuang Wan with no hepatorenal toxicity in transient ischemic brain injury. Toxicology and Applied Pharmacology2019, 114613.
13. Tsoi B, Chen X, Gao C, Wang S, Yuen SC, Yang D, Shen J. Neuroprotective effects and hepatorenal toxicity of Angong Niuhuang Wan against ischemia-reperfusion brain injury in rats. Frontiers in Pharmacology. 2019; 10:593
14. Chen X, Wu H, Chen H, Wang Q, Xie XJ, Shen J*. Astragaloside VI promotes neural stem cell proliferation and enhances neurological function recovery in transient cerebral ischemic injury via activating EGFR/MAPK signaling cascades. Molecular Neurobiology 2019; 56 (4), 3053-3067
15. Chen HS, Guan BH, Chen X, Chen XM, Li CM, Qiu JH, Yang D, Liu KJ, Q SH, Shen JG*.  Baicalin attenuates blood-brain barrier disruption and hemorrhagic transformation and improves neurological outcome in ischemic stroke rats with delayed t-PA treatment: Involvement of ONOO--MMP-9 pathway. Translational Stroke Research 2019; 9(5): 515-529
16. Li MD, Chen SM, Shi X, Liu CF, Zhang YF, Tan MQ, Wang C, Zang NL, Liu XX, Hu YF, Shen JG*, Zhou L, Gu Y.  Cell permeable HMGB1-binding heptamer peptide ameliorates neurovascular complications associated with thrombolytic therapy in rats with transient ischemic stroke. Journal of Neuroinflammation 2018; 55(12):9334-9348
17. Gao C, Du QH, Li WT, Deng RX, Wang Q, Xu A, Shen JG*. Baicalin modulates APPL2/glucocorticoid receptor signaling cascade, promotes neurogenesis and attenuates emotional and olfactory dysfunctions in chronic corticosterone induced depression. Molecular Neurobiology 2018;55(12):9334-9348.
18. Gao C, Chen X, Xu A, Cheng K, Shen JG*. Adaptor protein APPL2 affects adult antidepressant behaviors and hippocampal neurogenesis via regulating the sensitivity of glucocorticoid receptor. Molecular Neurobiology 2018; 55(7):5537-5547.
19. Feng J, Chen X, Lu S, Li W, Yang D, Su W, Wang X, Shen JG*. Naringin attenuates cerebral ischemia-reperfusion injury through inhibiting peroxynitrite-mediated mitophagy activation Molecular Neurobiology 2018, 55(12):9029-9042
20. Feng JH, Chen XM, Shen JG*. Inhibition of peroxynitrite-induced mitophagy activation attenuates cerebral ischemia-reperfusion injury. Molecular Neurobiology 2018, 55:6369-6386.
21. Li WT, Wu H, Gao C, Yang D, Yang DP, Shen JG*. Radix Rehmanniae Extract Ameliorates Experimental Autoimmune Encephalomyelitis by Suppressing Macrophage-derived Nitrative Damage. Frontiers in Physiology 2018; 9: 864
22. Chen X, Zhou B, Yan T, Wu H, Feng J, Chen H, Gao C, Peng T, Yang D, Shen JG* Peroxynitrite enhances self-renewal, proliferation, and neuronal differentiation of neural stem/progenitor cells through activating HIF-1a and Wnt/ß-catenin signaling pathway. Free Radical Biology and Medicine 2018; 117: 158-167
23. Deng R, Zhao B, Guan B, Chan GC, Shen JG*.  Marine algae extract attenuated osteoporosis in OVX mice, enhanced osteogenesis on human mesenchymal stem cells and promoted OPG expression. Journal of Functional Foods 2018; 40: 229-237.
24. Gao C, Shen JG*. Metabolic factors and adult neurogenesis: Impacts of Chinese herbal medicine on brain repair in neurological diseases.International Review of Neurobiology2017;135:117-147.
25. Gao C, Wang Q, Chung SK, Shen JG*. Crosstalk of metabolic factors and neurogenicsignaling in adult neurogenesis: Implication of metabolic regulation for mental andneurological diseases. Neurochemistry International  2017;135:117-147.
26. Feng J, Chen X, Shen JG*. Reactive nitrogen species as therapeutic targets for autophagy: implication for ischemic stroke. Expert Opinion Therapeutic Targets 21(3):305-317, 2017
27. Gao L, Chen XM, Peng T, Yang D, Lv ZP*, Shen JG*. Caveolin-1 protects against hepatic ischemia/reperfusion injury through ameliorating peroxynitrite-mediated cell death. Free Radical Biology and Medicine 2016, 95: 209–215
28. Wu H, Deng RX, Chen XM, Wong CW, Chen HS, Gao L, Nie YC, Wu WT, Shen JG*.  Caveolin-1 is critical for lymphocyte trafficking into central nervous system during experimental autoimmune encephalomyelitis. Journal of Neuroscience 36(19):5193-9, 2016
29. Chen HS, Chen XM, Feng JH, Liu KJ, Qi SH, Shen JG*.  Peroxynitrite decomposition catalyst reduces delayed thrombolysis-induced hemorrhagic transformation in ischemia-reperfused rat brains. CNS: Neuroscience and Therapeutics 2015; 21(7):585-90
30. Chen HS, Guan BH, Shen JG*. Targeting ONOO-/HMGB1/MMP-9 signaling cascades: Potential for drug development from Chinese Medicine to attenuate ischemic brain injury and hemorrhagictransformation induced by thrombolytic treatment. Integrative Medicine International 2015; 3(1-2): 32-52
31. Gong JJ, Sun FM, Li YH, Zhou XL, Duan ZZ, Duan FG, Zhao L, Chen HS, Qi SH*, Shen JG*. Momordica charantia polysaccharides could protect against cerebral ischemia/reperfusion injury through inhibiting oxidative stress mediated c-Jun N-terminal kinase 3 signaling pathway. Neuropharmacology 2015; 91:123-134.
32. Zhao L, Peng F, Guan B, Li X, Wu W, Chen J, Shen JG*. Whether Metal Element-containing Herbal Formula Angong Niuhuang Pill is Safe for Acute Brains Disorders? Biological Trace Element Research 2015;166(1):41-8.
33. Gu Y, Lee WS, Shen JG*. Site-2 protease responds to oxidative stress and regulates oxidative injury in mammalian cells. Scientific Reports 2014; 4:6268
34. Gao L, Zhou YC, Zhong WC, Chen C, Chen X, Gu Y, Chen J, Lv Z, Shen JG*. Caveolin-1 is essential for protecting against binge drinking-induced liver damage through inhibiting reactive nitrogen species. Hepatology 2014; 60(2):687-99
35. Zhu W, Zheng G, Gu Y, Chen X, Jin Y, Zhang G, Huang J, Shen JG*. Clinical efficacy and sEMG analysis of a new traditional Chinese medicine therapy in the treatment of spasticity followingapoplectic hemiparalysis.Acta Neurologica Belgica2014; 114(2):125-9
36. Chen Y, Wu H, Nie YC, Li PB, Shen JG*, Su WW*. Mucoactive effects of naringin in lipoploysaccharide-induced acute lung injury mice and beagle dogs. Environmental Toxicology and Pharmacology 2014; 38(1):279-287
37. Xu MJ, Chen XM, Gu Y, Peng T, Yang D, Chang RC, So KF, Liu KJ, Shen JG*.  Baicalin can scavenge peroxynitrite and ameliorate endogenous peroxynitrite-mediated neurotoxicity in cerebral ischemia-reperfusion injury. Journal of Ethnopharmacology 2013;150(1):116-124
38. Chen Y, Nie YC, Luo YL, Lin F, Zheng YF, Cheng GH, Wu H, Zhang KJ, Su WW, Shen JG*, Li PB*. Protective effects of naringin against paraquat-induced acute lung injury and pulmonary fibrosis in mice. Food and Chemical Toxicology 2013;58C:133-140.
39. Yang LP, Shen JG*, Xu WC, Li J, Jiang JQ*. Secondary metabolites of the genus astragalus: structure and biological-activity update. Chemistry & Biodiversity 2013; 10(6):1004-54
40. Du LB, Miao XX, Jiang YG, Jia HY, Tian Q, Shen JG*, Liu Y*. An effective strategy for the synthesis of biocompatible gold nanoparticles using danshensu antioxidant: prevention of cytotoxicity via attenuation of free radical formation. Nanotoxicology 2013; 7(3):294-300
41. Sun H, Ge N, Shao M, Cheng X, Li Y, Li S*, Shen JG*. Lumbrokinase attenuates diabetic nephropathy through regulating extracellular matrix degradation in Streptozotocin-induced diabetic rats. Diabetes Research and Clinical Practice 2013;100(1):85-95
42. Chen XM, Chen HS, Xu MJ, Shen JG*. Targeting reactive nitrogen species: A promising therapeutic strategy for cerebral ischemia-reperfusion injury. Acta Pharmacologica Sinica 2013; 34(1):67-77
43. Nie YC, Wu H, Li PB, Luo YL, Long K, Xie LM, Shen JG*, Su WW*. Anti-inflammatory effects of naringin in chronic pulmonary neutrophilic inflammation in cigarette smoke-exposed rats. Journal of Medicinal Food2012; 15(10): 894-900
44. Nie YC, Wu H, Li PB, Xie LM, Luo YL, Shen JG*, Su WW*. Naringin attenuates EGF-induced MUC5AC secretion in A549 cells by suppressing the cooperative activities of MAPKs-AP-1 and IKKs-IκB-NF-κB signaling pathways. European Journal of Pharmacology 2012; 690:207-213
45. Nie YC, Wu H, Li PB, Luo YL, Zhang CC, Shen JG*, Su WW*. Characteristic comparison of three rat models induced by cigarette smoke or combined with LPS: to establish a suitable model for study of airway mucus hypersecretion in chronic obstructive pulmonary disease. Pulmonary Pharmacology & Therapeutics 2012;25(5):349-358
46. Luo YL, Zhang CC, Li PB, Nie YC, Wu H, Shen JG*, Su WW*.  Naringin attenuates enhanced cough, airw>ay hyperresponsiveness and airway inflammation in a guinea pig model of chronicbronchitis induced by cigarette smoke. International Immunopharmacology2012; 13(3):301-307
47. Li Y, Zhuang PW, Shen BR, Zhang YJ, Shen JG*. Baicalin promotes neuronal differentiation of neural stem/progenitor cells through modulating p-stat3 and bHLH family protein expression. Brain Research1429: 36-42, 2012
48. Gu Y, Zheng GQ, Xu MJ, Li Y, Chen XM, Zhu WZ, Tong Y, Chung SK, Liu KJ,  Shen JG*. Caveolin-1 regulates nitric oxide mediated matrix metalloproteinases activity and blood-brain barrier permeability in focal cerebral ischemia and reperfusion injury. Journal of Neurochemistry 2012; 20(1):147-156
49. Zheng GQ, Zhao ZM, Wang Y, Gu Y, Li Y, Chen XM, Fu SP, Shen JG*. Meta-analysis of scalp acupuncture for acute hypertensive intracerebral hemorrhage.Journal of Alternative and Complementary Medicine 2011; 17(4):293-299
50. Lee W, Xu M, Li Y, Gu Y, Chen J, Wong D, Fung PC, Shen JG*. Free cholesterol accumulation impairs antioxidant activities and aggravates apoptotic cell death in menadione-induced oxidative injury.Archives of Biochemistry and Biophysics 2011; 514(1-2):57-67
51. Li Y, Luo J, Zheng G, Fu S, Wang TT, Zeng HP, So KF, Chung SK, Tong Y, Shen JG*. Caveolin-1 plays a crucial role in inhibiting neuronal differentiation of neural stem/progenitor cells via VEGF signaling-dependent pathway. PLoS One 2011; 6(8): e22901
52. Li Y, Lau WM, So KF, Tong Y, Shen JG*. Caveolin-1 promotes astroglial differentiation of neural stem/progenitor cells through modulating Notch1/NICD and Hes1 expressions. Biochemical and Biophysical Research Communications2011; 407: 517-524
53. Li Y, Lau WM, So KF, Tong Y, Shen JG*. Caveolin-1 inhibits oligodendroglial differentiation of neural stem/progenitor cells through modulating β-catenin expression, Neurochemistry International 2011; 59(2):114-121
54. Zheng GQ, Zhao ZM, Wang Y, Gu Y, Li Y, Chen XM, Fu SP, Shen JG*. Meta-analysis of scalp acupuncture for acute hypertensive intracerebral hemorrhage.Journal of Alternative and Complementary Medicine 2011; 17(4):293-299
55. Shen JG*, Lee W.S., Chen J. and Yang D. Caveolin-3 peptide protects cardiomyocytes from apoptotic cell death via preserving superoxide dismutase activity and inhibiting caspase-3 activation under hypoxia-reoxygenation. American Journal of Biomedical Sciences3(2): 126-144, 2011
56. Shen JG*, Gu Y, Tong Y, Fung PC, Tong L. Ginkgo biloba extract (EGb 761) prevents apoptosis in hypoxia-reoxygenated cardiomyocytes: involvement of mitochondria-dependent caspase pathway. Chinese Medicine 2011 6(1): 8
57. Shen JG, Sood R, Weaver J, Timmins GS, Schnell A, Miyake M, Kao JP, Rosen GM, Liu KJ. Direct visualization of mouse brain oxygen distribution by electron paramagnetic resonance imaging: Application to focal cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism2009; 29(10):1695-703.
58. Mao WW, Wang TT, Zeng HP, Wang ZY, Chen JP, Shen JG*. The design, synthesis, and evaluation of novel substituted 5-hydroxycoumarin and pyranocoumarin derivatives exhibiting high antiproliferative activity. Bioorganic & Medicinal Chemistry Letters2009;19(16):4570-4573
59. Shen JG*, Lee WS, Lau CF, Ng KM, Fung ML, Liu KJ. Interaction of caveolin-1, nitric oxide, and nitric oxide synthases in hypoxic human SK-N-MC neuroblastoma cells.  Journal of Neurochemistry2008; 107:478-487
60. Zeng HP, Wang, TT, Chen W, Wang CY, Chen DH, Shen JG*. Characterization of the chemical components in the extracts fromSi-wu decoction induce proliferation of rat mesenchymal stem cells (rMSCs). Bioorganic & Medicinal Chemistry 2008; 16(9):5109-5114
61. Shi J, Tong Y, Shen JG, Li HX. Effectiveness and safety of herbal medicines in the treatment of irritable bowel syndrome: A systematic review. World Journal of Gastroenterology2008; 14(3): 454-462
62. Cai GX, Liu BY, Liu W, Tan XH, Rong JH, Chen XM, Tong L, Shen JG*. Buyang Huanwu Decoction can improve recovery of neurological function, reduce infarction volume, stimulate neural proliferation and modulate VEGF and Flk1 expressions in transient focal cerebral ischaemic rat brains. Journal of Ethnopharmacology 2007;113(2):292-299
63. Ren JY, Fung PC, Chang CQ, Shen GX, Chan FH, Shen JG*. A comparison study on blood and tissue nitric oxide concentration during renal ischemia-reperfusion injury with electron paramagnetic resonance spectroscopy. Applied Magnetic Resonance2007; 32:243-255,
64. Shen JG, Liu SM, Miyake M, Liu WL, Pritchard A, Kao JP, Rosen GM, Timmins GS, Tong Y, Liu KJ. Use of 3-acetoxymethoxycarbonyl-2,2,5,5-tetramethyl-1 -pyrrolidinyloxyl as an EPR oximetry probe for measurement of tissue oxygenation in mouse brain. Magnetic Resonance in Medicine 2006;55: 1433-1440
65. Yang D, Wang HL, Sun ZN, Chung NW, Shen JG*. A highly selective fluorescent probe for detection of peroxynitrite in living cells. Journal of The American Chemical Society 2006;128(18):6004-6005  
66. Shen JG*, Ma S, Chan CP, Fung PC, Cheung RTF, Liu KJ. Nitric oxide down-regulates caveolin-1 expression in rat brains during focal cerebral ischemia and reperfusion. Journal of Neurochemistry 2006; 96; 1078-1089
67. Shen JG, Khan N, Lewis LD, Ray A, Swartz H. Cellular respiration rates and oxygen concentration in lymphoblastic Molt-4 cells and there ρ0 derivative. Biophysical Journal 2003; 84(2): 1291-1298
68. Shen JG, Qiu XS, Jiang B, Zhang DL, Xin WJ, Fung PC, Zhao BL. Nitric oxide and oxygen radicals induced apoptosis via bcl-2 and p53 pathway in hypoxia-reoxygenated cardiomyocytes. Science China - Life Sciences 2003; 46(1): 28-39 
69. Shen JG, Bottle S, Khan N, Micallef A, Swartz HM.  Development of isoindoline nitroxides for EPR oxymetry in viable biological systems. Applied Magnetic Resonance2002; 22:357-368
70. Shen JG, Li M, Xin WJ, Zhao BL.  Effects of Chinonin on nitric oxide free radical, myocardial damage and arrhythmia in ischemia-reperfusion injury in vivo. Applied Magnetic Resonance19: 9-19, 2000.
71. Shen JG, Quo X, Li M, Xin WJ, Zhao BL. Chinonin, a novel drug against cardiomyocyte apoptosis induced by hypoxia and reoxygenation. Biochimica et Biophysica Acta- Molecular Basis of Diseases 2000; 1500: 217-226
72. Shen JG, Wang J, Zhao BL, Hou JW, Gao TL, Xin WJ.  Effects of EGb 761 on generation of nitric oxide, myocardial damage and arrhythmias in ischemia-reperfusion injury in vivo. Biochimica et Biophysica Acta- Molecular Basis of Diseases 1998; 1406:228-236
73. Shen JG, Zhou D. Efficiency of Ginkgo biloba extract (EGb 761) in antioxidant protection against myocardial ischemia and reperfusion injury. Biochemistry and Molecular Biology International1995; 35(1): 125-134

 

Original Articles as Co-authors

74. Ma J, Fan H, Cai H, Hu Z, Zhou X, Li F, Chen H, Shen J, Qi S. Promotion of Momordica Charantia polysaccharides on neural stem cell proliferation by increasing SIRT1 activity after cerebral ischemia/reperfusion in rats. Brain Research Bulletin 2021; 170: 254-263.
75. Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A ,… Shen J.,… Klionsky DJ.  Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).  Autophagy 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280
76. Hu Z, Li F, Zhou X, Zhang F, Huang L, Gu G, Shen J, Qi S. Momordica Charantia Polysaccharides Modulate the Differentiation of Neural Stem Cells via SIRT1/Β-Catenin Axis in Cerebral Ischemia/Reperfusion. Stem Cell Research & Therapy 11:485, 2020
77. Xu H, Shen J, Xiao J, Chen F, Wang M. Neuroprotective effect of cajaninstilbene acid against cerebral ischemia and reperfusion damages by activating AMPK/Nrf2 pathway. Journal of Advanced Research (In press),https://doi.org/10.1016/j.jare.2020.07.011
78. Zheng Y, Qin Z, Tsoi B, Shen J, Zhang ZJ. Electroacupuncture on trigeminal nerve-innervated acupoints ameliorates post-stroke cognitive impairment in rats with middle cerebral artery occlusion: involvement of neuroprotection and synaptic plasticity. Neural Plasticity 2020;2020:8818328.
79. Ye S,  Hananya N, Green O, Chen H, Zhao AQ,  Shen J, Shabat D, Yang D.  A highly selective and sensitive chemiluminescent probe for real-time monitoring of hydrogen peroxide in cells and animals. Angewandte Chemie International Edition. 2020 ; 59(34): 14326-14330
80. Zhou X, Ding X, Shen J, Yang D, Hudson LG, Liu KJ. Peroxynitrite contributes to arsenic-induced PARP-1 inhibition through ROS/RNS generation. Toxicology and Applied Pharmacology 2019; 114602.
81. Bai X, Yang B, Chen H, Shen J, Yang D. HKOCl-4: A rhodol-based yellow fluorescent probe for the detection of hypochlorous acid in living cells and tissues. Organic Chemistry Frontiers 2020, 7, 993-996
82. Xu H, Deng R, Li ET, Shen J, Wang M. Pinosylvin provides neuroprotection against cerebral ischemia and reperfusion injury through enhancing PINK1/Parkin mediated mitophagy and Nrf2 pathway. Journal of Functional Foods2020; 71, 104019, 
83. Lin R, Duan Z, Sun H, Fung ML, Chen H, Wang J, Lau CF, Yang D, Liu Y, Ni Y, Wang Z, Cui J, Wu W, Yung WH, Chan YS, Lo ACY, Xia J, Shen J, Huang JD. Kinesin-1 regulates extrasynaptic targeting of NMDARs and neuronal vulnerability toward excitotoxicity. iScience. 2019;13:82-97.
84. Jian W, Fang S, Chen T, Fang J, Mo Y, Li D, Xiong S, Liu W, Song L, Shen J, Xia Y, Wang Q, Hong H. A novel role of HuR in -epigallocatechin-3-gallate (EGCG) induces tumour cells apoptosis. Journal of Cellular and Molecular Medicine 2019;23(5):3767-3771.
85. Luo YX, Wang XY, Huang YJ, Fang SH, Wu J, Zhang YB, Xiong TQ, Yang C, Shen JG, Sang CL, Wang Q, Fang JS. Systems pharmacology-based investigation of Sanwei Ganjiang Prescription: related mechanisms in liver injury. Chinese Journal Natural Medicine 2018;16(10):756-765.
86. Deng RX, Law AHY, Shen JG, Chan GCF. Mini review: Application of human mesenchymal stem cells in gene and stem cells therapy era. Current Stem Cell Reports 2018; 4 (4), 327-337
87. Mo YS, XU EJ, Wei RR, Le BL, Li DL, Chen YG, Li XT, Feng SH, Shen JG, Yang C, Wang Q. Bushen-Yizhi Formula alleviates neuroinflammation via inhibiting NLRP3 inflammasome activation in a mouse model of Parkinson’s disease.  Evidence-Based Complementary and Alternative Medicine 2018, Article ID 3571604
88. Peng F, Tang H, Liu P, Shen J, Guan X, Xie X, Gao J, Xiong L, Jia L, Chen J, Peng C. Isoliquiritigenin modulates miR-374a/PTEN/Akt axis to suppress breast cancertumorigenesis and metastasis. Scientific Reports 2017;7(1):9022.
89. Chan LK, Ganotice F Jr, Wong FKY, Lau CS, Bridges SM, Chan CHY, Chan N, Chan PWL, Chen HY, Chen JY, Chu JKP, Ho CC, Ho JMC, Lam TP, Lam VSF, Li Q, Shen JG, Tanner JA, Tso WWY, Wong AKC, Wong GTC, Wong JYH, Wong NS, Worsley A, Yu LK, Yum TP.Implementation of an interprofessional team-based learning program involving sevenundergraduate health and social care programs from two universities, and students'evaluation of their readiness for interprofessional learning. BMC Medical Education 2017;17(1):221.
90. Tang H, Peng F, Huang X, Xie X, Chen B, Shen J, Gao F, You J, Xie X, Chen J. Neoisoliquiritigenin inhibits tumor progression by targeting GRP78-β-catenin signaling in breast cancer. Current Cancer Drug Targets. 2018;18(4):390-399. 
91. Cai C, Wu Q, Luo Y, Ma H, Shen J, Zhang Y, Yang L, Chen Y, Wen Z, Wang Q. In silico prediction of ROCK II inhibitors by different classification approaches.Molecular Diversity2017 21(4):791-807.
92. Qi Z, Liang J, Pan R, Dong W, Shen JG, Yang Y, Zhao Y, Shi W, Luo Y, Ji X, Liu KJ. Zinc contributes to acute cerebral ischemia-induced blood-brain barrier disruption. Neurobiology of Disease2016; 95:12-21.
93. Peng T, Chen XM, Gao L, Zhang T, Wang W, Shen JG, Yang D. A rationally designed rhodamine-based fluorescent probe for molecular imaging of peroxynitrite in live cells and tissues. Chemical Science 2016; 7(8):5407-5413.
94. Hu JJ, Wong NK, Lu MY, Chen XM, Ye S, Zhao AQ, Gao P, Kao RY, Shen JG, Yang D. HKOCl-3: a fluorescent hypochlorous acid probe for live-cell and in vivo imaging and quantitative application in flow cytometry and a 96-well microplate assay. Chemical Science 2016;7(3):2094-2099
95. Zhao Y, Xu P, Hu S, Du L, Xu Z, Zhang H, Cui W, Mak S, Xu D, Shen J, Han Y, Liu Y, Xue M. Tanshinone II A, a multiple target neuroprotectant, promotes caveolae-dependent neuronaldifferentiation. European Journal of Pharmacology 2015; 765:437-446
96. Hu JJ, Wong NK, Ye S, Chen XM, Lu MY, Zhao AQ, Guo Y, Ma AC, Leung AY, Shen JG, Yang D. Fluorescent probe HKSOX-1 for imaging and detection of endogenous superoxide in live cells and in vivo.  Journal of the American Chemical Society 2015; 137(21):6837-6843
97. Wang N, Wang Z, Wang Y, Shen JG, Peng C, You JS, Peng F, Guan X, Chen J. Dietary compound Isoliquiritigenin prevents mammary carcinogenesis by inhibiting breast cancer stem cells through WIF1 demethylation. Oncotarget 2015; 6 (12):9854-76
98. Sun H, Shen JG*, Liu T, Tan Y, Tian D, Luo T, Lai W, Dai M, Guo Z*. Heat shock protein 65 promotes atherosclerosis through impairing the properties of high density lipoprotein. Atherosclerosis 2014; 237(2):853-861
99. Wang N, Wang Z, Peng C, You J, Shen JG, Han S, Chen J. Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via β-catenin/ABCG2 signaling. Carcinogenesis 2014; 35(11):2544-54
100. Peng T, Wong NK, Chen XM, Chan YK, Ho DH, Sun ZN, Hu J, Shen JG, El-Nezami H, Yang D. Molecular imaging of peroxynitrite with HKGreen-4 in live cells and tissues. Journal of the American Chemical Society 2014; 136(33):11728-34
101. Qi Z, Yan F, Shi W, Zhang C, Dong W, Zhao Y, Shen JG, Ji X, Liu KJ, Luo YM. AKT-related autophagy contributes to the neuroprotective efficacy of Hydroxysafflor Yellow A against ischemic stroke in rats. Translational Stroke Research 2014; 5(4):501-509
102. Wang ZY, Li WP, Liu PX, Chen QJ, Situ H, Zhong SW, Guo L, Lin Y, Shen JG, Chen JP. Caveolin-1 mediates chemoresistance in breast cancer stem cells via β-catenin/ABCG2 signaling pathway. Carcinogenesis 2014; 35(10):2346-56
103. Hua YQ, Chen Z, Meng ZQ, Chen H, Shen JG, WANG K, Peng W, Shen YH, Liu LM. High expression of erythropoietin producing hepatoma cell line-B2 (EphB2) predicts the efficiency of the Qingyihuaji formula treatment in pancreatic cancer CFPAC‑ 1 cells through the EphrinB1‑ EphB2 pathway. Oncology Letters 2014; 8(1):17-24 
104. Yeung PK, Shen JG, Chung SS, Chung SK. Targeted over-expression of endothelin-1 in astrocytes leads to more severe brain damage and vasospasm after subarachnoid hemorrhage.BMC Neuroscience 2013;14:131
105. Pan Y, Zhao L, Chen XM, Gu Y, Shen JG, Liu LM. The XRCC1 Arg399Gln genetic polymorphism contributes to hepatocellular carcinoma susceptibility: an updated meta-analysis. Asian Pacific Journal of Cancer Prevention. 2013;14(10):5761-5767
106. Du LB, Miao XX, Jiang YG, Jia HY, Tian Q, Shen JG*, Liu Y*. An effective strategy for the synthesis of biocompatible gold nanoparticles using danshensu antioxidant: prevention of cytotoxicity via attenuation of free radical formation. Nanotoxicology 2013; 7(3):294-300
107. Wang ZY, Wang N, Han SW, Wang DM, Mo SL, Yu LZ, Huang H, Tsui KC, Shen JG, Chen JP. Dietary compound isoliquiritigenin inhibits breast cancer neoangiogenesis via VEGF/VEGFR-2 signaling pathway. PLoS One 2013; 8(7):e68566
108. Wang ZY, Wang DM, Han SW, Wang N, Mo FZ, Loo TY, Shen JG, Huang H, Chen JP. Bioactivity-guided identification and cell signaling technology to delineate the lactate dehydrogenase A: Inhibition effects of Spatholobus suberectus on breast cancer. PLoS One 2013; 8(2): e56613
109. Lau BW, Lee JC Lee, Li Y, Fung SM, Sang YH, Shen JG, Chang RC, So KF. Polysaccharides from wolfberry prevents corticosterone-induced inhibition of sexual behavior and increases neurogenesis. PLoS One 2012;7(4): e33374
110. Wang ZY, Loo TY, Shen JG, Wang N, Wang DM, Yang DP, Mo SL, Guan XY, Chen JP. LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis.Breast Cancer Research and Treatment 2012; 1(3):791-800
111. Wang N, Wang  ZY,  Mo SL, Loo TY, Wang DM,  Luo HB , Yang DP,  Chen LY,  Shen JG,  Chen JP*. Ellagic acid, a phenolic compound, exerts anti-angiogenesis effects via VEGFR-2 signaling pathway in breast cancer. Breast Cancer Research and Treatment 2012; 134(3):943-55
112. Hao CZ, Wu F, Shen JG, Lu L, Fu DL, Liao WJ, Zheng GQ.  Clinical efficacy and safety of Buyang Huanwu decoction for acute ischemic stroke: A systematic review and Meta-analysis of 19 randomized controlled trials, Evidence-based Complementary and Alternative Medicine 2012, Article ID. 630124(Impact Factor 1.79, Google Citation 52)
113. Wang Y, Shen JG, Wang XM, Fu DL, Chen CY, Lu LY, Lu L, Xie CL, Fang JQ, Zheng GQ. Scalp Acupuncture for acute ischemic stroke: a meta-analysis of randomized controlled trials. Evidence-based Complementary and Alternative Medicine 2012, Article ID. 480950
114. Wang Z, Cheng Y, Wang N, Wang DM, Li YW, Han F, Shen JG, Yang DP, Guan XY, Chen JP. Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins. Cancer Biology & Therapy 2012;13(3), 138-147
115. Li Z, Yang D*, Huang M, Hu X, Shen JG, Zhao Z, Chen J. Chrysomya megacephala (Fabricius) larvae: A new biodiesel resource. Applied Energy2012; 94: 349-354 (Impact Factor 9.27, Google Citation 42)
116. Wang ZY, Wang DM, Loo TY, Cheng Y, Chen LL, Shen JG, Yang DP, Chow LW, Guan XY, Chen JP. Spatholobus suberectus Dunn inhibits cancer angiogenesis through suppression of vascular endothelial growth factor signaling pathway. Journal of Ethnopharmacology 2011; 133(2):751-758
117. Xu YC, Yang Y, Du LB, Shen JG, Wang GQ, He Z, Tian Q, Liu Y. Autoxidation and prooxidation mechanism of Danshensu. Acta Physico-Chemica Sinica 2010;26(7):1737-1741
118. Zhai JJ, Liu ZL,Li JM, Chen JP, Jiang L,Wang DM, Yuan J,Shen JG, Yang DP, Chen JQ. Different mechanisms of cis-9,trans-11- and trans-10,cis-12- conjugated linoleic acid affecting lipid metabolism in 3T3-L1 cells. Journal of Nutritional Biochemistry 2010; 21(11):1099-1105
119. Ye XS, Feng YB, Tong Y, Ng KM, Tsao SW, Liu GK, Sze CW, Zhang YB, Tang J, Shen JG, Kobayashi S. Hepatoprotective and anti-oxidative effects of Coptidis Rhizoma aqueous extract on carbon tetrachloride-induced acute liver hepatotoxicity in rats. Journal of Ethnopharmacology2009; 4(1):130-6  
120. Liu WL, Hendren J, Yuan ZR, Shen JG, Liu KJ. Normobaric hyperoxia attenuates early blood brain barrier disruption by inhibiting MMP-9-mediated occluding in focal cerebral ischemia. Journal of Neurochemistry   2009; 108:811-820
121. Zeng HP, Wang, TT, Chen W, Wang CY, Chen DH, Shen JG*. Characterization of the chemical components in the Extracts fromSi-wu decoction induce proliferation of rat mesenchymal stem cells (rMSCs). Bioorganic & Medicinal Chemistry 2008; (9):5109-5114
122. Rong JH, Cheung CY, Lau AS, Shen JG, Tam PH, Cheng YC. Induction of heme oxygenase-1 by traditional Chinese medicine formulation ISF-1 and its ingredients as a cytoprotective mechanism against oxidative stress, International Journal of Molecular Medicine 2008; 21: 405-411
123. Rong JH, Titon R, Shen JG, Ng KM, Liu C, Tam PK, Lau AS, Cheng YC. Genome-wide biological response fingerprinting (BioReF) of the Chinese botanical formulation ISF-1 enables the selection of multiple marker genes as a potential metric for quality control. Journal of Ethnopharmacology  2007; 113(1):35-44
124. Miyake M, Shen JG, Liu SM, Shi HL, Liu WL, Yuan ZR, Pritchard A, Kao JPY, Liu KJ, Rosen GM. Acetoxymethoxycarbonyl nitroxides as EPR pro-imaging agents to measure O2 levels in mouse brain: A pharmacokinetic and pharmacodynamic study. Journal of Pharmacology and Experimental Therapeutics2006; 318, 1187-1193
125. Chen BY, Lam KS, Wang Y, Wu DH, Lam MC, Shen JG, Wong LC, Hoo RL, Zhang JL, Xu AM. Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes. Biochemical and Biophysical Research Communications2006; 341: 549-556
126. Chang CQ, Ren JY, Fung PCW, Hung YS, Shen JG, Chan FHY. Novel sparse component analysis approach to free radical EPR spectra decomposition. Journal of Magnetic Resonance 2005;175: 242-255
127. Ren JY, Chang CQ, Fung PCW, Shen JG, Chan FHY. Free Radical EPR Spectroscopy Analysis using blind source separation. Journal of Magnetic Resonance2004; 166(1):82-91
128. Yang D, Sun ZN, Peng T, Wang HL, Shen JG, Chen Y, Tam PK. Synthetic fluorescent probes for imaging of peroxynitrite and hypochlorous acid in living cells. Methods in Molecular Biology 2010; 591:93-103
129. Yang D, Wang HL, Sun ZN, Chung NW, Shen JG. A highly selective fluorescent probe for detection of peroxynitrite in living cells. Journal of The American Chemical Society 2006;128(18):6004-6005
130. Khan N, Shen JG, Chang TY, Fung PCW, Grinberg O, Swartz H. Plasma membrane cholesterol: a possible barrier to intracellular oxygen gradients in CHO cells. Biochemistry 2003; 42(1): 23-29
131. Xu AG, Li SG, Liu JH, Shen JG, Jiang B, Gang AH. Correlation between apoptosis and proliferation in gastric pre-carcinomatic patients. Chinese Medical Journal 1999;79(3):185-186
132. Zhao B, Shen JG, Li M, Li MF, Wan Q, Xin WJ.  Scavenging effects of Chinonin on NO and oxygen free radicals and its protective effects on the myocardium from the injury of ischemia-reperfusion. Biochimica et Biophysica Acta- Molecular Basis of Diseases 1996; 1315: 131-137
133. Zhao BL, Shen JG, Hu J, Wan Q, Xin W. Synergic effects of NO and oxygen free radicals in the injury of ischemia-reperfused myocardium---ESR studies on NO free radicals generated from ischemia-reperfused myocardium. Science in China - Life Sciences 1996; 26: 491-500

 

Invited Review Articles

134. Leung YL, Guan B, Chen S, Chan H, Kong K, Li W, Shen J. Artificial intelligence meets traditional Chinese medicine: a bridge to opening the magic box of sphygmopalpation for pulse pattern recognition. Digital Chinese Medicine 2021: 4:1-8
135. Chen X, Chen HS, Peng C, Shen J*. Active compounds and molecular targets of Chinese herbal medicine for neurogenesis in stroke treatment: Implication for cross talk between Traditional Chinese Medicine and Biomedical Sciences. World Journal of Traditional Chinese Medicine 2019; 5(2): 104-115.
136. Shen JG. Clinical efficacy and therapeutic mechanisms of Traditional Chinese Medicine for neuroprotection and neurogenesis in stroke treatment. Digital Chinese Medicine2018; 1: 191-198.
137. Chen HS, Chen X, Li WT, Shen JG*. Targeting RNS/caveolin-1/MMP signaling cascades to protect against cerebral ischemia-reperfusion injuries: potential application for drugdiscovery.Acta Pharmacologica Sinica 2018;39(5):669-682. 
138. Gao C, Shen JG*. Metabolic factors and adult neurogenesis: Impacts of Chinese herbal medicine on brain repair in neurological diseases.International Review of Neurobiology2017;135:117-147.
139. Gao C, Wang Q, Chung SK, Shen JG*. Crosstalk of metabolic factors and neurogenicsignaling in adult neurogenesis: Implication of metabolic regulation for mental andneurological diseases. Neurochemistry International 2017;135:117-147.
140. Wu H, Shen JG*. Focusing on caveolin-1 in CNS autoimmune disease: multiple sclerosis. Neural Regeneration Research 2016;11(12):1920-1921
141. Feng J, Chen X, Shen JG*. Reactive nitrogen species as therapeutic targets for autophagy: implication for ischemic stroke. Expert Opinion Therapeutic Targets 21(3):305-317, 2017
142. Chen HS, Qi SH, Shen JG*. One-Compound-Multi-Target: Combination prospect of naturalcompounds with thrombolytic therapy in acute ischemic stroke. Current Neuropharmacology 2017;15(1):134-156
143. Chen HS, Guan BH, Shen JG*. Targeting ONOO-/HMGB1/MMP-9 signaling cascades: Potential for drug development from Chinese Medicine to attenuate ischemic brain injury and hemorrhagictransformation induced by thrombolytic treatment. Integrative Medicine International 2015; 3(1-2): 32-52
144. Peng F, Du QH, Peng C, Tang HL, Xie XM, Shen JG, Chen JP. A review: The pharmacology of isoliquiritigenin. Phytotherapy Research2015; 29(7):969-77
145. Chen XM, Chen HS, Deng RX, Shen JG*. Pros and cons of current approaches for detecting peroxynitrite and their applications. Biomedical Journal 2014, 37 (3), 120-126
146. Gu Y, Chen JP, Shen JG*. Herbal Medicines for Ischemic Stroke: Combating Inflammation as Therapeutic Targets. Journal of Neuroimmune Pharmacology 2014; 9:313-339
147. Shen JG*, Chen XM, Chen X, Deng RX. Targeting Neurogenesis: A Promising Therapeutic Strategy for Post-stroke Treatment with Chinese Herbal Medicine. Integrative Medicine International 1:5-18, 2014
148. Zhang E, Shen JG, So KF. Chinese traditional medicine and adult neurogenesis in the hippocampus.  Journal of Traditional and Complementary Medicine 2014; 4:77-81
149. Yang LP, Shen JG*, Xu WC, Li J, Jiang JQ*. Secondary metabolites of the genus astragalus: structure and biological-activity update. Chemistry & Biodiversity 2013; 10(6):1004-1054
150. Chen XM, Chen HS, Xu MJ, Shen JG*. Targeting reactive nitrogen species: A promising therapeutic strategy for cerebral ischemia-reperfusion injury. Acta Pharmacologica Sinica 2013; 34(1):67-77
151. Wang ZY, Wang N, Chen J*, Shen JG*. Emerging glycolysis targeting and drug discovery from Chinese Medicine in cancer therapy. Evidence-based Complementary and Alternative Medicine 2012, Article ID. 873175  
152. Shen JG*. Reactive nitrogen species: Dual roles for blood brain barrier disruption and brain repairs in cerebral ischemia and reperfusion injury.Acta Biophysica Sinica 2012;28 (4): 295-306 
153. Zhao H*, Ren CC, Chen XM, Shen JG. From rapid to delayed and remote postconditioning: the evolving concept of ischemic postconditioning in brain ischemia. Current Drug Targets13(2): 173-187, 2012
154. Xu WC, Shen JG*. Jiang JQ. Phytochemical and biological studies of the plants from the genus daphne.2011; 8: 1215-1233  
155. Gu Y, Dee CM, Shen JG*. Interaction of free radicals, matrix metalloproteinases and caveolin-1 impacts blood-brain barrier permeability in cerebral ischemia and reperfusion injury. Frontier in Bioscience 2011; 3: 1216-1231
156. Zheng GQ, Li Y, Gu Y, Chen XM, Zhou Y, Zhao SZ, Shen JG*. Beyond Water Channel:Aquaporin-4 in Adult Neurogenesis. Neurochemistry International. 2010; 56(5):651-654

Representative Articles in Chinese Academic Journals

1. 沈劍剛。 活血化瘀在中醫中藥治療腦中風病的應用探討. 香港中醫藥雜誌  11(2): 40-43, 2016
2. 沈劍剛。  中醫藥教育與人才培養漫談. 湖南中醫藥大學學報  2: 88-89, 2016
3. 林蓓茵, 沈劍剛。 從六經氣化論治更年期高血壓。 香港中醫藥雜誌 2016
4. 朱文宗, 鄭國慶, 黃建平, 金永喜, 劉偉, 沈劍剛。 豁痰健脾法治療後半規管良性陣發性位置性眩暈臨床研究. 新中醫45(2): 83-85, 2013.
5. 仝小林, 沈劍剛, 王躍生,傅延齡, 徐國良, 連鳳梅, 饒毅, 餘日躍, 劉安, 宋軍, 劉文科, 陳欣燕, 徐立鵬, 趙錫艷, 周強, 趙林華。 慢病方藥合理用量理論探討. 世界中醫藥 9(1):1-27, 2014
6. 朱文宗, 金永喜, 黃建平, 章國偉, 吳紅專, 沈劍剛。 解痙合劑結合運動治療改善腦卒中後肌痙攣及表面肌電圖分析. 浙江中西醫結合雜志45(2):84-87, 2013.
7. 潘巖, 花永強, 劉魯明, 沈劍剛。 無血清培養法分離並鑒定胰腺癌細胞系 BxPC-3 中腫瘤幹細胞. 中國腫瘤6:441-445, 2012
8. 蘇彥雷, 張驥, 蔣建勤, 林克江, 沈劍剛。 量子化學計演演算法分析蒙古黃芪中部分黃酮類化合物抗氧化作用機制. 中國藥科大學學報 18: 1-6, 2011
9. 塗天智, 沈劍剛, 蔣建勤。 內蒙黃芪的化學成分研究 華西藥學雜誌 24 (5): 466-468; 2009
10. 劉柏炎, 沈劍剛, 蔡光先, 謝勇, 陳雪梅, 楊輝。 補陽還五湯對局灶性腦缺血大鼠腦內 caveolin1、2 的影響. 湖南中醫藥大學學報28(1): 22-28, 2008
11. 劉柏炎, 蔡光先, 陳雪梅, 楊輝, 謝勇, 沈劍剛。 補陽還五湯對局灶性腦缺血大鼠神經元再生的影響。中華神經醫學雜誌 2007﹕6(8)﹕762-765 
12. 佟麗, 譚縣輝, 沈劍剛。  補陽還五湯及不同配伍組方對缺血性腦中風後大鼠神經增殖作用的對比研究。 中國中西醫結合雜誌 27(6): 519-22, 2007
13. 魯剛, 沈劍剛, 游文龍, 馮戩雲,朱建華. 直結腸癌細胞線粒體超微結構與細胞凋亡的關係. 中國誤診學雜誌 6(17): 3277-9, 2006
14. 張冬輝, 魯剛, 游文龍,  沈劍剛, 馮熾雲, 朱建華。 直結腸癌細胞線粒體研究中樣本的取材. 海南醫學院學報, 13(3):259-260, 2007 
15. 譚縣輝,曲宏達,彭康,陳育堯,佟麗,沈劍剛,朱傳武。 補陽還五湯對缺血性腦中風後遺症大鼠神經增殖作用的影響 南方醫科大學學報 26(2):189-192; 2006
16. 曲宏達,佟麗,沈劍剛。補陽還五湯含藥血清對缺氧腦皮質神經細胞 p53 和 p21 基因表達的作用。中國中西醫結合雜誌 24(2):133-5; 2004
17. 廖春來, 佟麗, 沈劍剛.  補陽還五湯對小鼠腦缺血後 NOS 活性的影響。 中藥藥理與臨床  19(4): 5-7, 2003
18. 廖春來, 佟麗, 沈劍剛。  補陽還五湯抗腦缺血的實驗研究進展。 中國藥物與臨床  3(3):176-178, 2003
19. 沈劍剛、丘幸生、薑泊、張德良、忻文娟、馮戠雲、趙保路。一氧化氮和氧自由基誘導缺氧再給氧心肌細胞凋亡的 bcl-2 和 p53 信號通路研究。中國科學 C 輯 32(5):436-446, 2002
20. 佟麗、沈劍剛、邱幸生、曲宏達、陳育堯。補陽還五湯抗缺氧再給氧乳鼠心肌細胞凋亡的實驗研究。中國中西醫結合雜誌 22(7): 522-524, 2002 
21. 曲宏達、 佟麗、沈劍剛、陳育堯。補陽還五湯對體外培養的大鼠皮層神經元缺氧凋亡的影響。第一軍醫大學學報 22(1) : 35-37, 2002
22. 佟麗. 曲宏達. 陳育堯. 沈劍剛。 補陽還五湯對大鼠腦皮層神經元生長的影響。 第一軍醫大學學報 22(8):711-712,2002  
23. 沈劍剛、佟麗、邱幸生、曲宏達、陳育堯。益氣通絡丹抗缺氧再給氧所致心肌細胞凋亡的研究。第一軍醫大學學報 21(10):743-745, 2001 
24. 許岸高、李韶光、劉集鴻、沈劍剛、甘愛華。黃參方劑治療胃癌中的細胞凋亡及一氧化氮機制的研究。中華結核和呼吸雜誌 24(3) : 169, 2001
25. 邱幸生、陳素雲、沈劍剛、黃偉毅、陳凱。益氣通絡方對缺氧再給氧心肌細胞 bcl-2 基因表達影響的血清藥理學研究。中國中醫基礎醫學雜誌 7(3) : 38-40,2001
26. 陳素雲、曲宏達、陸力、沈劍剛。一氧化氮對大鼠皮層神經元缺氧凋亡的影響及其 bc1-2 機制。長春中醫學院學報 16(7) : 28-29, 2000
27. 邱幸生、沈劍剛、陳素雲、黃偉毅。益氣通絡丹抗缺氧再給氧心肌細胞凋亡的實驗研究。 中國中醫藥科技 7(4): 213-215, 2000
28. 甘愛華、許岸高、 劉集鴻、李韶光、沈劍剛. 薑泊。 胃癌發生中增殖細胞核抗原與 bcl-2 和 p53 蛋白表達的意義。   臨床消化病雜誌  11(4):160-161,1999
29. 許岸高, 李韶光, 劉集鴻, 沈劍剛。氟尿嘧啶和黃參液誘導胃癌細胞株凋亡的研究。 中華消化雜誌  19(3):202-203,1999
30. 許岸高, 劉集鴻, 甘愛華, 沈劍剛, 鐘志強, 黃志輝。5-氟尿嘧啶誘導人胃癌細胞的凋亡。現代消化及介入診療 1:48, 1999
31. 許岸高, 沈劍剛,李韶光, 劉集鴻。 幽門螺桿菌感染所致胃粘膜上皮細胞凋亡與 p53 和 bcl-2 表達的關係現代消化及介入診療 1: 32-34, 1999
32. 劉集鴻、許岸高、沈劍剛。5-FU、絲裂黴素和表阿黴素誘導人胃癌細胞凋亡的體外研究。世界華人消化雜誌 4 : 365, 1999
33. 許岸高、李韶光、劉集鴻、沈劍剛、薑泊。胃癌前病變細胞凋亡和增殖的關係。中華醫學雜誌 79. (3):185-186, 1999
34. 劉集鴻. 許岸高. 沈劍剛。 5-氟尿嘧啶、絲裂黴素和表阿黴素誘導人胃癌細胞凋亡的體外研究。  廣東醫學 20(5)﹕327-328﹐ 1999
35. 許岸高, 劉集鴻, 沈劍剛, 甘愛華。  黃參方劑治療胃癌中的細胞凋亡及一氧化氮改變  中國實用內科雜誌 4233-235, 2001
36. 郭志剛、 沈劍剛、 翁昌鴻、佟麗、陳玉堯、賈滿盈、 劉伊麗。冠心病、高血壓病人血漿氧自由基、一氧化氮及纖溶活性的變化。第一軍醫大學學報 19(2) : 124-125, 1999
37. 沈劍剛、郭志剛等。益氣通絡丹對冠心病、高血壓病患者不同中醫證型血液脂質過氧化、一氧化氮及纖溶活性的影響。中國中醫基礎醫學雜誌 4(3) : 37-39,1998
38. 趙保路、沈劍剛。 用 DETC 鐵捕捉生物組織 NO 自由基的 ESR 波譜解析。波譜學雜誌 4:138-142,1998
39. 郭志剛, 沈劍剛, 佟麗, 陳育堯, 賈滿盈, 劉伊麗, 陳素雲。 銀杏葉提取物對冠心病患者的氧自由基一氧化氮及纖溶活性的影響。  嶺南心血管病雜誌 4(3):159-161,1998
40. 趙保路、沈劍剛等。用 ESR 研究缺血再灌注組織和多形核白細胞產生 NO 自由基。波譜學雜誌 14(2) : 99-105,1997
41. 沈劍剛、 郭志剛、 佟麗、 陳育堯、劉伊麗、 賈滿盈、 陳素雲、趙保路、 忻文娟。益氣通絡丹對冠心病高血壓病人脂質過氧化、一氧化氮及纖溶活性的影響。中國中西醫結合雜誌 17(7) :410-413, 1997
42. 沈劍剛、郭志剛等。益氣通絡丹對心肌缺血再灌注大鼠脂質過氧化及纖溶活性的影響。中國病理生理雜誌 12(2) : 139-143, 1996 (引用次數11)
43. 趙保路、沈劍剛、呼俊改、萬謙、忻文娟。NO 和氧自由基在心肌缺血再灌注損傷中的協同作用。中國科學 C 輯 26(4) : 331-338, 1996
44. 沈劍剛、趙保路、呼俊改、萬謙、忻文娟。益氣通絡丹對心肌缺血再灌注損傷 NO、氧自由基和心肌損傷的抑制作用。醫學生物物理學 8 : 7-11,1996
45. 郭志剛、沈劍剛等。冠心病高血壓病血漿 MDA、一氧化氮及組織型纖溶酶原啟動物的變化。中國迴圈雜誌 11(7) : 435, 1996
46. 佟麗、陳育堯、沈劍剛等。老年大鼠心肌缺血再灌注損傷及益氣通絡丹的保護作用。中國實驗方劑學雜誌 2(4) : 46-47, 1996
47. 沈劍剛; 郭志剛; 佟麗; 陳育堯; 薑翼; 許文學。 益氣通絡丹對冠心病、高血壓病患者血液氧自由基、NO 及纖溶活性的影響中藥藥理與臨床 3: 42-44, 1996
48. 賈鈺華, 陳素雲, 呂志平, 許文學, 崔志英, 沈劍剛。  舌色與心臟功能及血管功能的關係。  中國中西醫結合雜誌 15(6): 331-333, 1995
49. 郭志剛. 沈劍剛. 劉伊麗. 張榕華。 小劑量美降之治療高膽固醇血症臨床觀察 。 第一軍醫大學學報  15(4): 299, 1995
50. 沈劍剛、侯燦等。高壓氧所致脂質過氧化損傷。基礎醫學與臨床 12(3) : 59-60, 1992
51. 沈劍剛、陳瑗等。Ebselen 抗高壓氧脂質過氧化作用。中國藥理學通報 8(2) : 160-161, 1992
52. 沈劍剛、陳瑗、周玫等。 外源性 SOD 抗高壓氧脂質過氧化作用的實驗研究。中華醫學雜誌 71(11) : 642-644, 1991
53. 沈劍剛、陳瑗、周玫等。高氧靈和益氣通絡丹抗高壓氧脂質過氧化作用的實驗研究。中國中西醫結合雜誌 (增刊) : 337-340, 1991
54. 沈劍剛、陳瑗、周玫等。高壓氧所致脂質過氧化反應的初步探討。第一軍醫大學學報 10(4) : 351-353, 1990

Representative Books and Book Chapters

1. Gao C, Shen JG*. Metabolic Factors and Adult Neurogenesis: Impacts of Chinese Herbal Medicine on Brain Repair in Neurological Diseases. In: Chapter 6 International Review of Neurobiology. Elsevier, London, England 2017 DOI. 10.1016/bs.irn.2017.02.007
2. Shen JG*, Gu Y. Insights into mechanisms of blood brain barrier permeability: Roles of free radicals, matrix metalloproteinases and caveolin-1. Systems Biology of Oxidative Stress and Antioxidants. (Eds. Ismail Laher), Springer 2014, pp 2049-2067 (Citation 4)
3. Shen JG*, Chen XM. Drug discovery from Traditional Chinese Medicine for neurogenesis: Implications for stroke and neurodegenerative diseases. Traditional Chinese medicine__ Scientific Basis for its Use. (Eds. James D. Adams, Jr.). Royal Society of Chemistry, Thomas Graham House , Cambridge CB4 0WF, UK 2013 SBN: 978-1-84973-661-9 (Citation 3)
4. Feng YB, Chen XM, Wang N, Shen JG. Current Progress on Medicinal Plants and their Biological Properties in Contemporary China. In J.N. Govil, Recent Progress in Medicinal Plants. Studium Press LLC, Houston, USA , 2009, pp 529-588
5. Shen JG. Pharmacology and toxicology of Chinese herbal medicine for improving blood circulation. In: Yibin Feng, Pharmacology and Toxicology of Chinese Herbal Medicine. Commercial Press, Hong Kong 2009
6. Shen JG., Liu S., Miyake M. and Liu K.J., Cerebral tissue oxygenation: transportation, metabolism, measurement, and significance in the ischemic brain, In: John Zhang, Hyperbaric Oxygen for Neurological Disorders. Flagstaff, Arizona, U.S.A., Best Publishing Co. 2007, pp65-84
7. Shen JG, Zhao B, Li MF, Wan Q, and Xin W. Inhibitory effects of Ginkgo biloba extract (EGb 761) on oxygen free radicals, nitric oxide and myocardial injury in isolated ischemic-reperfused hearts. Proceedings of the International Symposium on Natural Antioxidant: Molecular Mechanisms and Health effects (Eds. Packer L, Traber MG  & Xin W), American Oil Chemistry Society Press, Champaign, Illinois, 1996, pp453-465 (Google Citation 4)
8. 沈劍剛, Chinese Medicine, Chapter 4,中國北京人民衛生出版社. 2021 年
9. 沈劍剛, 中醫科研英語,  副主編, 中國北京人民衛生出版社. 2016 年
10. 沈劍剛, 細胞凋亡的基礎與臨床, 中國北京人民軍醫出版社 1999 年
11. 沈劍剛, 新編中醫診斷學, 中國北京人民軍醫出版社 1998年
12. 沈劍剛, 醫學多媒體教學設計 中國北京人民軍醫出版社   1996年
13. 沈劍剛,藥物新劑型及其臨床應用     中國北京人民軍醫出版社   1996

Patents:

1. Method and usage of in vivo expanded immune potent iMSCs from human derived mesenchymal stem cells (IP00817 PCT Application in TTO application progress)
2. 来自地黄的提取物作为多发性硬化症的治 疗剂 中華人民共和國發明專利, CN 110693893, 發明人：沈剑刚 李雯婷, 公開日： 2019年9月10日
3. 一種抗缺血性卒中的試劑盒及其應用，中華人民共和國國家知識產權 CN109954112A已經受理，發明人：沈劍剛，陳漢森，蔡賓，吳煒，李霞, 公開日：2019年7月2日。
4. Kit combating ischemic stroke and use thereof.  World Patent: WO2019127672A1, Inventors: Shen J, Chen H, Tsoi B, Wu W, Li X. Publication Date: July 14, 2019
5. Neuroprotective compositions and methods. US Patent File 310.01110201 Inventors: Kejian Liu, Jiangang Shen
6. Reagents for highly specific detection of peroxynitrite, World Intellectual Property Organization (WIPO), WO2007041923, Inventors: Dan Yang, Hua-li Wang, Zhen-Ning Sun, Jiangang Shen, Publication Date: April 19, 2007
7. Reagents for highly specific detection of peroxynitrite, European Patent Office EP1943254A4, Inventors: Dan Yang, Hua-li Wang, Zhen-Ning Sun, Jiangang Shen, Publication Date: July 16, 2008
8. 用於檢測過氧亞硝酸鹽的二芳基胺基熒光探針 中華人民共和國發明專利 CN104220438 A發明人：楊丹 彭濤 沈劍剛 陳幸苗公開日： 2014年12月17日
9. Diarylamine-Based Fluorogenic Probes for Detection of Peroxynitrite. World Intellectual Property Organization (WIPO), Patent Scope, 2013 WO2013113279 A1, Inventors: Dan Yang, Tao Peng, Jiangang Shen, Xingmiao Chen. Publication Date:  August 8, 2013