Huang C, Chen G, Luo D, Zheng J, Zhong N, Li D, Luo Y, Huang P, Wang N, Feng Y, Zheng Y (2025). Bbox1, lacc1, mmp7 and sstr1 as common predictors in obesity and non-alcoholic fatty liver disease.. Genes & diseases, 12(2), 101310. https://doi.org/10.1016/j.gendis.2024.101310
Chen G, Ren Q, Zhong Z, Li Q, Huang Z, Zhang C, Yuan H, Feng Z, Chen B, Wang N, Feng Y (2024). Exploring the gut microbiome's role in colorectal cancer: diagnostic and prognostic implications.. Frontiers in immunology, 15(), 1431747. https://doi.org/10.3389/fimmu.2024.1431747
Feng Z, Chan YT, Lu Y, Wu J, Xing T, Yuan H, Feng Y, Wang N (2024). Siwu decoction suppress myeloid-derived suppressor cells through tumour cells necroptosis to inhibit hepatocellular carcinoma.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 133(), 155913. https://doi.org/S0944-7113(24)00571-3
Chan YT, Wu J, Lu Y, Li Q, Feng Z, Xu L, Yuan H, Xing T, Zhang C, Tan HY, Feng Y, Wang N (2024). Loss of lncrna linc01056 leads to sorafenib resistance in hcc.. Molecular cancer, 23(1), 74. https://doi.org/10.1186/s12943-024-01988-y
Wu J, Tan HY, Chan YT, Lu Y, Feng Z, Yuan H, Zhang C, Feng Y, Wang N (2024). Pard3 drives tumorigenesis through activating sonic hedgehog signalling in tumour-initiating cells in liver cancer.. Journal of experimental & clinical cancer research : CR, 43(1), 42. https://doi.org/10.1186/s13046-024-02967-3
Wu J, Chan YT, Lu Y, Feng Z, Yuan H, Xu X, Xu L, Zhang C, Feng Y, Tan HY, Wang N (2023). Genipin-activating ppargamma impedes ccr2-mediated macrophage infiltration into postoperative liver to suppress recurrence of hepatocellular carcinoma.. International journal of biological sciences, 19(16), 5257-5274. https://doi.org/10.7150/ijbs.87327
Lu Y, Chan YT, Wu J, Feng Z, Yuan H, Li Q, Xing T, Xu L, Zhang C, Tan HY, Lee TK, Feng Y, Wang N (2023). Crispr/cas9 screens unravel mir-3689a-3p regulating sorafenib resistance in hepatocellular carcinoma via suppressing ccs/sod1-dependent mitochondrial oxidative stress.. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, 71(), 101015. https://doi.org/S1368-7646(23)00098-5
Chan YT, Tan HY, Lu Y, Zhang C, Cheng CS, Wu J, Wang N, Feng Y (2023). Pancreatic melatonin enhances anti-tumor immunity in pancreatic adenocarcinoma through regulating tumor-associated neutrophils infiltration and netosis.. Acta pharmaceutica Sinica. B, 13(4), 1554-1567. https://doi.org/10.1016/j.apsb.2023.01.020
Lu Y, Liu Y, Lan J, Chan YT, Feng Z, Huang L, Wang N, Pan W, Feng Y (2023). Thioredoxin-interacting protein-activated intracellular potassium deprivation mediates the anti-tumour effect of a novel histone acetylation inhibitor hl23, a fangchinoline derivative, in human hepatocellular carcinoma.. Journal of advanced research, 51(), 181-196. https://doi.org/S2090-1232(22)00246-6
Chen X, Liu M, Tang J, Wang N, Feng Y, Ma H (2022). Research progress on the therapeutic effect of polysaccharides on non-alcoholic fatty liver disease through the regulation of the gut-liver axis.. International journal of molecular sciences, 23(19), . https://doi.org/10.3390/ijms231911710
Xu X, Zhang C, Wang N, Xu Y, Tang G, Xu L, Feng Y (2022). Bioactivities and mechanism of actions of dendrobium officinale: a comprehensive review.. Oxidative medicine and cellular longevity, 2022(), 6293355. https://doi.org/10.1155/2022/6293355
Chen G, Luo D, Zhong N, Li D, Zheng J, Liao H, Li Z, Lin X, Chen Q, Zhang C, Lu Y, Chan YT, Ren Q, Wang N, Feng Y (2022). Gpc2 is a potential diagnostic, immunological, and prognostic biomarker in pan-cancer.. Frontiers in immunology, 13(), 857308. https://doi.org/10.3389/fimmu.2022.857308
Zhang C, Tam CW, Tang G, Chen Y, Wang N, Feng Y (2022). Spatial transcriptomic analysis using r-based computational machine learning reveals the genetic profile of yang or yin deficiency syndrome in chinese medicine theory.. Evidence-based complementary and alternative medicine : eCAM, 2022(), 5503181. https://doi.org/10.1155/2022/5503181
Lu Y, Chan YT, Tan HY, Zhang C, Guo W, Xu Y, Sharma R, Chen ZS, Zheng YC, Wang N, Feng Y (2022). Epigenetic regulation of ferroptosis via ets1/mir-23a-3p/acsl4 axis mediates sorafenib resistance in human hepatocellular carcinoma.. Journal of experimental & clinical cancer research : CR, 41(1), 3. https://doi.org/10.1186/s13046-021-02208-x
Zhang C, Feng YG, Tam C, Wang N, Feng Y (2021). Transcriptional profiling and machine learning unveil a concordant biosignature of type i interferon-inducible host response across nasal swab and pulmonary tissue for covid-19 diagnosis.. Frontiers in immunology, 12(), 733171. https://doi.org/10.3389/fimmu.2021.733171
Wang N, Wang L, Zhang C, Tan HY, Zhang Y, Feng Y (2021). Berberine suppresses advanced glycation end products-associated diabetic retinopathy in hyperglycemic mice.. Clinical and translational medicine, 11(11), e569. https://doi.org/10.1002/ctm2.569
Wang N, Zhang C, Xu Y, Tan HY, Chen H, Feng Y (2021). Berberine improves insulin-induced diabetic retinopathy through exclusively suppressing akt/mtor-mediated hif-1alpha/vegf activation in retina endothelial cells.. International journal of biological sciences, 17(15), 4316-4326. https://doi.org/10.7150/ijbs.62868
Cheng CS, Tan HY, Wang N, Chen L, Meng Z, Chen Z, Feng Y (2021). Functional inhibition of lactate dehydrogenase suppresses pancreatic adenocarcinoma progression.. Clinical and translational medicine, 11(6), e467. https://doi.org/10.1002/ctm2.467
Xu Y, Wang N, Tan HY, Li S, Zhang C, Feng Y (2021). Gut-liver axis modulation of panax notoginseng saponins in nonalcoholic fatty liver disease.. Hepatology international, 15(2), 350-365. https://doi.org/10.1007/s12072-021-10138-1
Wang N, Tan HY, Lu Y, Chan YT, Wang D, Guo W, Xu Y, Zhang C, Chen F, Tang G, Feng Y (2021). Piwil1 governs the crosstalk of cancer cell metabolism and immunosuppressive microenvironment in hepatocellular carcinoma.. Signal transduction and targeted therapy, 6(1), 86. https://doi.org/10.1038/s41392-021-00485-8
Chen F, Zhong Z, Tan HY, Guo W, Zhang C, Cheng CS, Wang N, Ren J, Feng Y (2020). Suppression of lncrna malat1 by betulinic acid inhibits hepatocellular carcinoma progression by targeting iaps via mir-22-3p.. Clinical and translational medicine, 10(6), e190. https://doi.org/10.1002/ctm2.190
Xu Y, Wang N, Tan HY, Li S, Zhang C, Zhang Z, Feng Y (2020). Panax notoginseng saponins modulate the gut microbiota to promote thermogenesis and beige adipocyte reconstruction via leptin-mediated ampkalpha/stat3 signaling in diet-induced obesity.. Theranostics, 10(24), 11302-11323. https://doi.org/10.7150/thno.47746
Li S, Wang N, Tan HY, Chueng F, Zhang ZJ, Yuen MF, Feng Y (2020). Modulation of gut microbiota mediates berberine-induced expansion of immuno-suppressive cells to against alcoholic liver disease.. Clinical and translational medicine, 10(4), e112. https://doi.org/10.1002/ctm2.112
Guo W, Tan HY, Li S, Wang N, Feng Y (2020). Glutamic-pyruvic transaminase 1 facilitates alternative fuels for hepatocellular carcinoma growth-a small molecule inhibitor, berberine.. Cancers, 12(7), . https://doi.org/10.3390/cancers12071854
Chen F, Zhong Z, Tan HY, Wang N, Feng Y (2020). The significance of circulating tumor cells in patients with hepatocellular carcinoma: real-time monitoring and moving targets for cancer therapy.. Cancers, 12(7), . https://doi.org/10.3390/cancers12071734
Wang X, Zeng J, Wang X, Li J, Chen J, Wang N, Zhang M, Feng Y, Guo H (2020). 2,3,5,4'-tetrahydroxystilbene-2-o-beta-d-glucoside induces autophagy of liver by activating pi3k/akt and erk pathway in prediabetic rats.. BMC complementary medicine and therapies, 20(1), 177. https://doi.org/10.1186/s12906-020-02949-w
Zhang C, Wang N, Tan HY, Guo W, Chen F, Zhong Z, Man K, Tsao SW, Lao L, Feng Y (2020). Direct inhibition of the tlr4/myd88 pathway by geniposide suppresses hif-1alpha-independent vegf expression and angiogenesis in hepatocellular carcinoma.. British journal of pharmacology, 177(14), 3240-3257. https://doi.org/10.1111/bph.15046
Tan HY, Wang N, Chan YT, Zhang C, Guo W, Chen F, Zhong Z, Li S, Feng Y (2020). Id1 overexpression increases gefitinib sensitivity in non-small cell lung cancer by activating rip3/mlkl-dependent necroptosis.. Cancer letters, 475(), 109-118. https://doi.org/S0304-3835(20)30039-2
Tan HY, Ho VW, Chan YT, Zhang C, Wang N, Xia W, Feng Y (2020). Combination of gentiana rhodantha and gerbera anandria in the bl02 formula as therapeutics to non-small cell lung carcinoma acting via rap1/cdc42 signaling: a transcriptomics/ bio-informatics biological validation approach.. Pharmacological research, 155(), 104415. https://doi.org/S1043-6618(19)30835-7
Wang N, Tan HY, Li S, Wang D, Xu Y, Zhang C, Xia W, Che CM, Feng Y (2019). Sbp2 deficiency in adipose tissue macrophages drives insulin resistance in obesity.. Science advances, 5(8), eaav0198. https://doi.org/10.1126/sciadv.aav0198
Hong M, Shi H, Wang N, Tan HY, Wang Q, Feng Y (2019). Dual effects of chinese herbal medicines on angiogenesis in cancer and ischemic stroke treatments: role of hif-1 network.. Frontiers in pharmacology, 10(), 696. https://doi.org/10.3389/fphar.2019.00696
Qu Y, Dou B, Tan H, Feng Y, Wang N, Wang D (2019). Tumor microenvironment-driven non-cell-autonomous resistance to antineoplastic treatment.. Molecular cancer, 18(1), 69. https://doi.org/10.1186/s12943-019-0992-4
Li S, Wang N, Tan HY, Hong M, Yuen MF, Li H, Feng Y (2018). Expansion of granulocytic, myeloid-derived suppressor cells in response to ethanol-induced acute liver damage.. Frontiers in immunology, 9(), 1524. https://doi.org/10.3389/fimmu.2018.01524
Tan HY, Wang N, Li S, Hong M, Guo W, Man K, Cheng CS, Chen Z, Feng Y (2018). Repression of wt1-mediated lef1 transcription by mangiferin governs beta-catenin-independent wnt signalling inactivation in hepatocellular carcinoma.. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 47(5), 1819-1834. https://doi.org/10.1159/000491063
Wang N, Tan HY, Chan YT, Guo W, Li S, Feng Y (2017). Identification of wt1 as determinant of heptatocellular carcinoma and its inhibition by chinese herbal medicine salvia chinensis benth and its active ingredient protocatechualdehyde.. Oncotarget, 8(62), 105848-105859. https://doi.org/10.18632/oncotarget.22406
Zhang C, Xu Y, Tan HY, Li S, Wang N, Zhang Y, Feng Y (2018). Neuroprotective effect of he-ying-qing-re formula on retinal ganglion cell in diabetic retinopathy.. Journal of ethnopharmacology, 214(), 179-189. https://doi.org/S0378-8741(17)33527-4
Wang N, Tan HY, Li S, Feng Y (2017). Atg9b deficiency suppresses autophagy and potentiates endoplasmic reticulum stress-associated hepatocyte apoptosis in hepatocarcinogenesis.. Theranostics, 7(8), 2325-2338. https://doi.org/10.7150/thno.18225
Wang N, Wang X, Tan HY, Li S, Tsang CM, Tsao SW, Feng Y (2016). Berberine suppresses cyclin d1 expression through proteasomal degradation in human hepatoma cells.. International journal of molecular sciences, 17(11), . https://doi.org/1899
Tan HY, Wang N, Tsao SW, Che CM, Yuen MF, Feng Y (2016). Ire1alpha inhibition by natural compound genipin on tumour associated macrophages reduces growth of hepatocellular carcinoma.. Oncotarget, 7(28), 43792-43804. https://doi.org/10.18632/oncotarget.9696
Wang N, Xu Q, Tan HY, Hong M, Li S, Yuen MF, Feng Y (2016). Berberine inhibition of fibrogenesis in a rat model of liver fibrosis and in hepatic stellate cells.. Evidence-based complementary and alternative medicine : eCAM, 2016(), 8762345. https://doi.org/10.1155/2016/8762345
Wang X, Wang N, Li H, Liu M, Cao F, Yu X, Zhang J, Tan Y, Xiang L, Feng Y (2016). Up-regulation of pai-1 and down-regulation of upa are involved in suppression of invasiveness and motility of hepatocellular carcinoma cells by a natural compound berberine.. International journal of molecular sciences, 17(4), 577. https://doi.org/10.3390/ijms17040577
Wang L, Wang N, Tan HY, Zhang Y, Feng Y (2015). Protective effect of a chinese medicine formula he-ying-qing-re formula on diabetic retinopathy.. Journal of ethnopharmacology, 169(), 295-304. https://doi.org/S0378-8741(15)00297-4
Wang N, Feng Y, Tan HY, Cheung F, Hong M, Lao L, Nagamatsu T (2015). Inhibition of eukaryotic elongation factor-2 confers to tumor suppression by a herbal formulation huanglian-jiedu decoction in human hepatocellular carcinoma.. Journal of ethnopharmacology, 164(), 309-18. https://doi.org/S0378-8741(15)00103-8
Wang N, Feng Y, Cheung F, Wang X, Zhang Z, Feng Y (2015). A chinese medicine formula gegen qinlian decoction suppresses expansion of human renal carcinoma with inhibition of matrix metalloproteinase-2.. Integrative cancer therapies, 14(1), 75-85. https://doi.org/10.1177/1534735414550036
Wang N, Zhu M, Wang X, Tan HY, Tsao SW, Feng Y (2014). Berberine-induced tumor suppressor p53 up-regulation gets involved in the regulatory network of mir-23a in hepatocellular carcinoma.. Biochimica et biophysica acta, 1839(9), 849-57. https://doi.org/S1874-9399(14)00141-2
Xu B, Wang N, Pan W, Qiu J, Cao P, Zhu M, Feng Y, Liang G (2014). Synthesis and anti-tumor activity evaluation of matijin-su derivatives.. Bioorganic chemistry, 56(), 34-40. https://doi.org/S0045-2068(14)00040-6
Tan HY, Wang N, Tsao SW, Zhang Z, Feng Y (2014). Suppression of vascular endothelial growth factor via inactivation of eukaryotic elongation factor 2 by alkaloids in coptidis rhizome in hepatocellular carcinoma.. Integrative cancer therapies, 13(5), 425-34. https://doi.org/10.1177/1534735413513635
Wang N, Zhu M, Tsao SW, Man K, Zhang Z, Feng Y (2013). Mir-23a-mediated inhibition of topoisomerase 1 expression potentiates cell response to etoposide in human hepatocellular carcinoma.. Molecular cancer, 12(1), 119. https://doi.org/10.1186/1476-4598-12-119
Wang N, Feng Y, Zhu M, Siu FM, Ng KM, Che CM (2013). A novel mechanism of xiap degradation induced by timosaponin aiii in hepatocellular carcinoma.. Biochimica et biophysica acta, 1833(12), 2890-2899. https://doi.org/S0167-4889(13)00293-0
Wang N, Feng Y, Cheung F, Chow OY, Wang X, Su W, Tong Y (2012). A comparative study on the hepatoprotective action of bear bile and coptidis rhizoma aqueous extract on experimental liver fibrosis in rats.. BMC complementary and alternative medicine, 12(), 239. https://doi.org/10.1186/1472-6882-12-239
Wang N, Zhu M, Tsao SW, Man K, Zhang Z, Feng Y (2012). Up-regulation of timp-1 by genipin inhibits mmp-2 activities and suppresses the metastatic potential of human hepatocellular carcinoma.. PloS one, 7(9), e46318. https://doi.org/10.1371/journal.pone.0046318
Feng Y, Wang N, Ye X, Li H, Feng Y, Cheung F, Nagamatsu T (2011). Hepatoprotective effect and its possible mechanism of coptidis rhizoma aqueous extract on carbon tetrachloride-induced chronic liver hepatotoxicity in rats.. Journal of ethnopharmacology, 138(3), 683-90. https://doi.org/10.1016/j.jep.2011.09.032
Wang N, Pan W, Zhu M, Zhang M, Hao X, Liang G, Feng Y (2011). Fangchinoline induces autophagic cell death via p53/sestrin2/ampk signalling in human hepatocellular carcinoma cells.. British journal of pharmacology, 164(2b), 731-42. https://doi.org/10.1111/j.1476-5381.2011.01349.x
Wang N, Feng Y, Xie TN, Su W, Zhu M, Chow O, Zhang Y, Ng KM, Leung CH, Tong Y (2011). Chemical and biological analysis of active free and conjugated bile acids in animal bile using hplc-elsd and mtt methods.. Experimental and therapeutic medicine, 2(1), 125-130.
Wang N, Feng Y, Lau EP, Tsang C, Ching Y, Man K, Tong Y, Nagamatsu T, Su W, Tsao S (2010). F-actin reorganization and inactivation of rho signaling pathway involved in the inhibitory effect of coptidis rhizoma on hepatoma cell migration.. Integrative cancer therapies, 9(4), 354-64. https://doi.org/10.1177/1534735410379121
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Zhao J, Sun Y, Feng Y, Rong J (2024). Brain specific raga overexpression triggers depressive-like behaviors in mice via activating adora2a signaling pathway.. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 11(45), e2404188. https://doi.org/10.1002/advs.202404188
Kubi JA, Brah AS, Cheung KMC, Chen ACH, Lee YL, Lee KF, Qiao W, Feng Y, Yeung KWK (2024). Low-molecular-weight estrogenic phytoprotein suppresses osteoporosis development through positive modulation of skeletal estrogen receptors.. Bioactive materials, 42(), 299-315. https://doi.org/10.1016/j.bioactmat.2024.08.045
Zhang S, Wu J, Wang L, Mu L, Xu X, Li J, Tang G, Chen G, Zhang C, Zhang Y, Feng Y (2024). Sirt1/p53 in retinal pigment epithelial cells in diabetic retinopathy: a gene co-expression analysis and he-ying-qing-re formula treatment.. Frontiers in molecular biosciences, 11(), 1366020. https://doi.org/10.3389/fmolb.2024.1366020
Cheng D, Qin ZS, Zheng Y, Xie JY, Liang SS, Zhang JL, Feng YB, Zhang ZJ (2023). Minocycline, a classic antibiotic, exerts psychotropic effects by normalizing microglial neuroinflammation-evoked tryptophan-kynurenine pathway dysregulation in chronically stressed male mice.. Brain, behavior, and immunity, 107(), 305-318. https://doi.org/S0889-1591(22)00427-5
Xu B, Bai L, Chen L, Tong R, Feng Y, Shi J (2022). Terpenoid natural products exert neuroprotection via the pi3k/akt pathway.. Frontiers in pharmacology, 13(), 1036506. https://doi.org/10.3389/fphar.2022.1036506
Liu K, Guo Y, Chen X, Duan J, Li B, Liu M, Chen L, Li M, Feng Y, Li H, Wang X (2022). Quality control, preparation process optimizing and anti-inflammatory effects of premna puberula pamp. pectin.. Heliyon, 8(10), e11082. https://doi.org/10.1016/j.heliyon.2022.e11082
Liu Q, Kwan KY, Cao T, Yan B, Ganesan K, Jia L, Zhang F, Lim C, Wu Y, Feng Y, Chen Z, Liu L, Chen J (2022). Broad-spectrum antiviral activity of spatholobus suberectus dunn against sars-cov-2, sars-cov-1, h5n1, and other enveloped viruses.. Phytotherapy research : PTR, 36(8), 3232-3247. https://doi.org/10.1002/ptr.7452
Wang L, Yang Y, Tan HY, Li S, Feng Y (2020). Protective actions of acidic hydrolysates of polysaccharide extracted from mactra veneriformis against chemical-induced acute liver damage.. Frontiers in pharmacology, 11(), 446. https://doi.org/10.3389/fphar.2020.00446
Yang N, Li C, Li H, Liu M, Cai X, Cao F, Feng Y, Li M, Wang X (2019). Emodin induced srebp1-dependent and srebp1-independent apoptosis in hepatocellular carcinoma cells.. Frontiers in pharmacology, 10(), 709. https://doi.org/10.3389/fphar.2019.00709
Song TH, Chen XX, Lee CK, Sze SC, Feng YB, Yang ZJ, Chen HY, Li ST, Zhang LY, Wei G, Shi J, Xu K, Ng TB, Zhu LL, Zhang KY (2019). Dendrobine targeting jnk stress signaling to sensitize chemotoxicity of cisplatin against non-small cell lung cancer cells in vitro and in vivo.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 53(), 18-27. https://doi.org/S0944-7113(18)30204-6
Li H, Xiang L, Yang N, Cao F, Li C, Chen P, Ruan X, Feng Y, Zhou N, Wang X (2018). Zhiheshouwu ethanol extract induces intrinsic apoptosis and reduces unsaturated fatty acids via srebp1 pathway in hepatocellular carcinoma cells.. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 119(), 169-175. https://doi.org/S0278-6915(18)30276-X
Cheng Y, Feng Y, Xia Z, Li X, Rong J (2017). Omega-alkynyl arachidonic acid promotes anti-inflammatory macrophage m2 polarization against acute myocardial infarction via regulating the cross-talk between pkm2, hif-1alpha and inos.. Biochimica et biophysica acta. Molecular and cell biology of lipids, 1862(12), 1595-1605. https://doi.org/S1388-1981(17)30202-0
Huang J, Tang H, Cao S, He Y, Feng Y, Wang K, Zheng Q (2017). Molecular targets and associated potential pathways of danlu capsules in hyperplasia of mammary glands based on systems pharmacology.. Evidence-based complementary and alternative medicine : eCAM, 2017(), 1930598. https://doi.org/10.1155/2017/1930598
Tsang CM, Cheung KC, Cheung YC, Man K, Lui VW, Tsao SW, Feng Y (2015). Berberine suppresses id-1 expression and inhibits the growth and development of lung metastases in hepatocellular carcinoma.. Biochimica et biophysica acta, 1852(3), 541-51. https://doi.org/S0925-4439(14)00376-7
Ouyang L, Zhang Q, Ruan X, Feng Y, Wang X (2014). Treatment effect of bushen huayu extract on postmenopausal osteoporosis in vivo.. Experimental and therapeutic medicine, 7(6), 1687-1690.
Wang D, Wong HK, Feng YB, Zhang ZJ (2014). Liquiritigenin exhibits antitumour action in pituitary adenoma cells via ras/erks and ros-dependent mitochondrial signalling pathways.. The Journal of pharmacy and pharmacology, 66(3), 408-17. https://doi.org/10.1111/jphp.12170
Wang D, Wong HK, Feng YB, Zhang ZJ (2014). 18beta-glycyrrhetinic acid induces apoptosis in pituitary adenoma cells via ros/mapks-mediated pathway.. Journal of neuro-oncology, 116(2), 221-30. https://doi.org/10.1007/s11060-013-1292-2
Wang D, Wong HK, Feng YB, Zhang ZJ (2013). Paeoniflorin, a natural neuroprotective agent, modulates multiple anti-apoptotic and pro-apoptotic pathways in differentiated pc12 cells.. Cellular and molecular neurobiology, 33(4), 521-9. https://doi.org/10.1007/s10571-013-9914-y
Wang D, Wong HK, Zhang L, McAlonan GM, Wang XM, Sze SC, Feng YB, Zhang ZJ (2012). Not only dopamine d2 receptors involved in peony-glycyrrhiza decoction, an herbal preparation against antipsychotic-associated hyperprolactinemia.. Progress in neuro-psychopharmacology & biological psychiatry, 39(2), 332-8. https://doi.org/S0278-5846(12)00164-9
Ye X, Feng Y, Tong Y, Ng KM, Tsao S, Lau GK, Sze C, Zhang Y, Tang J, Shen J, Kobayashi S (2009). Hepatoprotective effects of coptidis rhizoma aqueous extract on carbon tetrachloride-induced acute liver hepatotoxicity in rats.. Journal of ethnopharmacology, 124(1), 130-6.
Tsang CM, Lau EP, Di K, Cheung PY, Hau PM, Ching YP, Wong YC, Cheung AL, Wan TS, Tong Y, Tsao SW, Feng Y (2009). Berberine inhibits rho gtpases and cell migration at low doses but induces g2 arrest and apoptosis at high doses in human cancer cells.. International journal of molecular medicine, 24(1), 131-8.
Sze SC, Song JX, Wong RN, Feng YB, Ng TB, Tong Y, Zhang KY (2008). Application of scar (sequence characterized amplified region) analysis to authenticate lycium barbarum (wolfberry) and its adulterants.. Biotechnology and applied biochemistry, 51(Pt 1), 15-21.
Wu M, Yu S, Yan S, Wu M, Zhang L, Chen S, Shi D, Liu S, Fan Y, Lin X, Shen J (2024). Peroxynitrite reduces treg cell expansion and function by mediating il-2r nitration and aggravates multiple sclerosis pathogenesis.. Redox biology, 75(), 103240. https://doi.org/S2213-2317(24)00218-0
Huang LY, Zhang YD, Chen J, Fan HD, Wang W, Wang B, Ma JY, Li PP, Pu HW, Guo XY, Shen JG, Qi SH (2025). Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke.. Neural regeneration research, 20(3), 845-857. https://doi.org/10.4103/1673-5374.392889
Mo M, Yin L, Wang T, Lv Z, Guo Y, Shen J, Zhang H, Liu N, Wang Q, Huang S, Huang H (2024). Associations of essential metals with the risk of aortic arch calcification: a cross-sectional study in a mid-aged and older population of shenzhen, china.. MedComm, 5(5), e533. https://doi.org/10.1002/mco2.533
Chen S, Pan J, Gong Z, Wu M, Zhang X, Chen H, Yang D, Qi S, Peng Y, Shen J (2024). Hypochlorous acid derived from microglial myeloperoxidase could mediate high-mobility group box 1 release from neurons to amplify brain damage in cerebral ischemia-reperfusion injury.. Journal of neuroinflammation, 21(1), 70. https://doi.org/10.1186/s12974-023-02991-8
Liang R, Ye ZW, Qin Z, Xie Y, Yang X, Sun H, Du Q, Luo P, Tang K, Hu B, Cao J, Wong XH, Ling GS, Chu H, Shen J, Yin F, Jin DY, Chan JF, Yuen KY, Yuan S (2024). Pmi-controlled mannose metabolism and glycosylation determines tissue tolerance and virus fitness.. Nature communications, 15(1), 2144. https://doi.org/10.1038/s41467-024-46415-4
Du Q, Gao C, Tsoi B, Wu M, Shen J (2023). Niuhuang qingxin wan ameliorates depressive-like behaviors and improves hippocampal neurogenesis through modulating trkb/erk/creb signaling pathway in chronic restraint stress or corticosterone challenge mice.. Frontiers in pharmacology, 14(), 1274343. https://doi.org/10.3389/fphar.2023.1274343
Du Q, Liang R, Wu M, Yang M, Xie Y, Liu Q, Tang K, Lin X, Yuan S, Shen J (2024). Alisol b 23-acetate broadly inhibits coronavirus through blocking virus entry and suppresses proinflammatory t cells responses for the treatment of covid-19.. Journal of advanced research, 62(), 273-290. https://doi.org/S2090-1232(23)00294-1
Liu A, Chen Z, Li X, Xie C, Chen Y, Su X, Chen Y, Zhang M, Chen J, Yang T, Shen J, Huang H (2023). C5a-c5ar1 induces endoplasmic reticulum stress to accelerate vascular calcification via perk-eif2alpha-atf4-creb3l1 pathway.. Cardiovascular research, 119(15), 2563-2578. https://doi.org/10.1093/cvr/cvad133
Liao Y, Lai Y, Xu H, Gao L, Fu X, Wang X, Wang Q, Shen J, Fang J, Fang S (2023). Bushen-yizhi formula ameliorates mitochondrial dysfunction and oxidative stress via ampk/sirt1 signaling pathway in d-gal-induced aging rats.. Chinese medicine, 18(1), 53. https://doi.org/10.1186/s13020-023-00755-3
Chen X, Shen J, Zhou Q, Jin X, Liu H, Gao R (2022). Astragaloside vi ameliorates post-stroke depression via upregulating the nrg-1-mediated mek/erk pathway.. Pharmaceuticals (Basel, Switzerland), 15(12), . https://doi.org/10.3390/ph15121551
Huang LY, Ma JY, Song JX, Xu JJ, Hong R, Fan HD, Cai H, Wang W, Wang YL, Hu ZL, Shen JG, Qi SH (2023). Ischemic accumulation of succinate induces cdc42 succinylation and inhibits neural stem cell proliferation after cerebral ischemia/reperfusion.. Neural regeneration research, 18(5), 1040-1045. https://doi.org/10.4103/1673-5374.355821
Cai H, Huang LY, Hong R, Song JX, Guo XJ, Zhou W, Hu ZL, Wang W, Wang YL, Shen JG, Qi SH (2022). Momordica charantia exosome-like nanoparticles exert neuroprotective effects against ischemic brain injury via inhibiting matrix metalloproteinase 9 and activating the akt/gsk3beta signaling pathway.. Frontiers in pharmacology, 13(), 908830. https://doi.org/10.3389/fphar.2022.908830
Wu M, Yu S, Chen Y, Meng W, Chen H, He J, Shen J, Lin X (2022). Acteoside promotes b cell-derived il-10 production and ameliorates autoimmunity.. Journal of leukocyte biology, 112(4), 875-885. https://doi.org/10.1002/JLB.3MA0422-510R
Gao C, Wu M, Du Q, Deng J, Shen J (2022). Naringin mediates adult hippocampal neurogenesis for antidepression via activating creb signaling.. Frontiers in cell and developmental biology, 10(), 731831. https://doi.org/10.3389/fcell.2022.731831
Chen H, Luo Y, Tsoi B, Gu B, Qi S, Shen J (2022). Angong niuhuang wan reduces hemorrhagic transformation and mortality in ischemic stroke rats with delayed thrombolysis: involvement of peroxynitrite-mediated mmp-9 activation.. Chinese medicine, 17(1), 51. https://doi.org/10.1186/s13020-022-00595-7
Yu S, Wu M, Feng Y, Shen J, Lu L, Lin X (2022). Detection of t follicular helper cells and t follicular regulatory cells in experimental sjogren's syndrome.. Methods in molecular biology (Clifton, N.J.), 2380(), 211-224. https://doi.org/10.1007/978-1-0716-1736-6_18
Wu W, Wang Y, Li H, Chen H, Shen J (2021). Buyang huanwu decoction protects against stz-induced diabetic nephropathy by inhibiting tgf-beta/smad3 signaling-mediated renal fibrosis and inflammation.. Chinese medicine, 16(1), 118. https://doi.org/10.1186/s13020-021-00531-1
Du Q, Deng R, Li W, Zhang D, Tsoi B, Shen J (2021). Baoyuan capsule promotes neurogenesis and neurological functional recovery through improving mitochondrial function and modulating pi3k/akt signaling pathway.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 93(), 153795. https://doi.org/S0944-7113(21)00338-X
Zhang F, Liu Q, Ganesan K, Kewu Z, Shen J, Gang F, Luo X, Chen J (2021). The antitriple negative breast cancer efficacy of spatholobus suberectus dunn on ros-induced noncanonical inflammasome pyroptotic pathway.. Oxidative medicine and cellular longevity, 2021(), 5187569. https://doi.org/10.1155/2021/5187569
Leung AYL, Chen H, Jia Z, Li X, Shen J (2021). Study protocol: traditional chinese medicine (tcm) syndrome differentiation for heart failure patients and its implication for long-term therapeutic outcomes of the qiliqiangxin capsules.. Chinese medicine, 16(1), 103. https://doi.org/10.1186/s13020-021-00515-1
Wu W, Huang XR, You Y, Xue L, Wang XJ, Meng X, Lin X, Shen J, Yu X, Lan HY, Chen H (2021). Latent tgf-beta1 protects against diabetic kidney disease via arkadia/smad7 signaling.. International journal of biological sciences, 17(13), 3583-3594. https://doi.org/10.7150/ijbs.61647
Wen Y, Chen H, Zhang L, Wu M, Zhang F, Yang D, Shen J, Chen J (2021). Glycyrrhetinic acid induces oxidative/nitrative stress and drives ferroptosis through activating nadph oxidases and inos, and depriving glutathione in triple-negative breast cancer cells.. Free radical biology & medicine, 173(), 41-51. https://doi.org/S0891-5849(21)00418-4
Luo Y, Chen H, Tsoi B, Wang Q, Shen J (2021). Danggui-shaoyao-san (dss) ameliorates cerebral ischemia-reperfusion injury via activating sirt1 signaling and inhibiting nadph oxidases.. Frontiers in pharmacology, 12(), 653795. https://doi.org/10.3389/fphar.2021.653795
Gu Y, Chen X, Fu S, Liu W, Wang Q, Liu KJ, Shen J (2021). Astragali radix isoflavones synergistically alleviate cerebral ischemia and reperfusion injury via activating estrogen receptor-pi3k-akt signaling pathway.. Frontiers in pharmacology, 12(), 533028. https://doi.org/10.3389/fphar.2021.533028
Ma J, Fan H, Cai H, Hu Z, Zhou X, Li F, Chen H, Shen J, Qi S (2021). Promotion of momordica charantia polysaccharides on neural stem cell proliferation by increasing sirt1 activity after cerebral ischemia/reperfusion in rats.. Brain research bulletin, 170(), 254-263. https://doi.org/S0361-9230(21)00058-7
He Y, Chen S, Tsoi B, Qi S, Gu B, Wang Z, Peng C, Shen J (2020). Alpinia oxyphylla miq. and its active compound p-coumaric acid promote brain-derived neurotrophic factor signaling for inducing hippocampal neurogenesis and improving post-cerebral ischemic spatial cognitive functions.. Frontiers in cell and developmental biology, 8(), 577790. https://doi.org/10.3389/fcell.2020.577790
Chen H, Guan B, Chen S, Yang D, Shen J (2021). Peroxynitrite activates nlrp3 inflammasome and contributes to hemorrhagic transformation and poor outcome in ischemic stroke with hyperglycemia.. Free radical biology & medicine, 165(), 171-183. https://doi.org/S0891-5849(21)00047-2
Hu Z, Li F, Zhou X, Zhang F, Huang L, Gu B, Shen J, Qi S (2020). Momordica charantia polysaccharides modulate the differentiation of neural stem cells via sirt1/beta-catenin axis in cerebral ischemia/reperfusion.. Stem cell research & therapy, 11(1), 485. https://doi.org/10.1186/s13287-020-02000-2
Li Y, Zhao Y, Gao C, Wu M, So KF, Tong Y, Shen J (2020). Caveolin-1 derived from brain microvascular endothelial cells inhibits neuronal differentiation of neural stem/progenitor cells in vivo and in vitro.. Neuroscience, 448(), 172-190. https://doi.org/S0306-4522(20)30605-9
Zheng Y, Qin Z, Tsoi B, Shen J, Zhang ZJ (2020). Electroacupuncture on trigeminal nerve-innervated acupoints ameliorates poststroke cognitive impairment in rats with middle cerebral artery occlusion: involvement of neuroprotection and synaptic plasticity.. Neural plasticity, 2020(), 8818328. https://doi.org/10.1155/2020/8818328
Zhang Y, He Y, Wu M, Chen H, Zhang L, Yang D, Wang Q, Shen J (2020). Rehmapicroside ameliorates cerebral ischemia-reperfusion injury via attenuating peroxynitrite-mediated mitophagy activation.. Free radical biology & medicine, 160(), 526-539. https://doi.org/S0891-5849(20)31131-X
Chen X, Chen H, He Y, Fu S, Liu H, Wang Q, Shen J (2020). Proteomics-guided study on buyang huanwu decoction for its neuroprotective and neurogenic mechanisms for transient ischemic stroke: involvements of egfr/pi3k/akt/bad/14-3-3 and jak2/stat3/cyclin d1 signaling cascades.. Molecular neurobiology, 57(10), 4305-4321. https://doi.org/10.1007/s12035-020-02016-y
Xu H, Shen J, Xiao J, Chen F, Wang M (2021). Neuroprotective effect of cajaninstilbene acid against cerebral ischemia and reperfusion damages by activating ampk/nrf2 pathway.. Journal of advanced research, 34(), 199-210. https://doi.org/10.1016/j.jare.2020.07.011
Chen S, Chen H, Du Q, Shen J (2020). Targeting myeloperoxidase (mpo) mediated oxidative stress and inflammation for reducing brain ischemia injury: potential application of natural compounds.. Frontiers in physiology, 11(), 433. https://doi.org/10.3389/fphys.2020.00433
Ye S, Hananya N, Green O, Chen H, Zhao AQ, Shen J, Shabat D, Yang D (2020). A highly selective and sensitive chemiluminescent probe for real-time monitoring of hydrogen peroxide in cells and animals.. Angewandte Chemie (International ed. in English), 59(34), 14326-14330. https://doi.org/10.1002/anie.202005429
Gao C, Yan T, Chen X, Cheng KKY, Xu A, Shen J (2020). Appl2 negatively regulates olfactory functions by switching fate commitments of neural stem cells in adult olfactory bulb via interaction with notch1 signaling.. Neuroscience bulletin, 36(9), 997-1008. https://doi.org/10.1007/s12264-020-00514-6
Chen H, Guan B, Wang B, Pu H, Bai X, Chen X, Liu J, Li C, Qiu J, Yang D, Liu K, Wang Q, Qi S, Shen J (2020). Glycyrrhizin prevents hemorrhagic transformation and improves neurological outcome in ischemic stroke with delayed thrombolysis through targeting peroxynitrite-mediated hmgb1 signaling.. Translational stroke research, 11(5), 967-982. https://doi.org/10.1007/s12975-019-00772-1
Li W, Deng R, Jing X, Chen J, Yang D, Shen J (2020). Acteoside ameliorates experimental autoimmune encephalomyelitis through inhibiting peroxynitrite-mediated mitophagy activation.. Free radical biology & medicine, 146(), 79-91. https://doi.org/S0891-5849(19)30976-1
Li W, Feng J, Gao C, Wu M, Du Q, Tsoi B, Wang Q, Yang D, Shen J (2019). Nitration of drp1 provokes mitophagy activation mediating neuronal injury in experimental autoimmune encephalomyelitis.. Free radical biology & medicine, 143(), 70-83. https://doi.org/S0891-5849(19)30465-4
Tsoi B, Wang S, Gao C, Luo Y, Li W, Yang D, Yang D, Shen J (2019). Realgar and cinnabar are essential components contributing to neuroprotection of angong niuhuang wan with no hepatorenal toxicity in transient ischemic brain injury.. Toxicology and applied pharmacology, 377(), 114613. https://doi.org/S0041-008X(19)30215-7
Tsoi B, Chen X, Gao C, Wang S, Yuen SC, Yang D, Shen J (2019). Neuroprotective effects and hepatorenal toxicity of angong niuhuang wan against ischemia-reperfusion brain injury in rats.. Frontiers in pharmacology, 10(), 593. https://doi.org/10.3389/fphar.2019.00593
Zhou X, Ding X, Shen J, Yang D, Hudson LG, Liu KJ (2019). Peroxynitrite contributes to arsenic-induced parp-1 inhibition through ros/rns generation.. Toxicology and applied pharmacology, 378(), 114602. https://doi.org/S0041-008X(19)30204-2
Lin R, Duan Z, Sun H, Fung ML, Chen H, Wang J, Lau CF, Yang D, Liu Y, Ni Y, Wang Z, Cui J, Wu W, Yung WH, Chan YS, Lo ACY, Xia J, Shen J, Huang JD (2019). Kinesin-1 regulates extrasynaptic targeting of nmdars and neuronal vulnerability toward excitotoxicity.. iScience, 13(), 82-97. https://doi.org/S2589-0042(19)30043-4
Jian W, Fang S, Chen T, Fang J, Mo Y, Li D, Xiong S, Liu W, Song L, Shen J, Xia Y, Wang Q, Hong H (2019). A novel role of hur in -epigallocatechin-3-gallate (egcg) induces tumour cells apoptosis.. Journal of cellular and molecular medicine, 23(5), 3767-3771. https://doi.org/10.1111/jcmm.14249
Chen H, Chen X, Luo Y, Shen J (2018). Potential molecular targets of peroxynitrite in mediating blood-brain barrier damage and haemorrhagic transformation in acute ischaemic stroke with delayed tissue plasminogen activator treatment.. Free radical research, 52(11-12), 1220-1239. https://doi.org/10.1080/10715762.2018.1521519
Luo YX, Wang XY, Huang YJ, Fang SH, Wu J, Zhang YB, Xiong TQ, Yang C, Shen JG, Sang CL, Wang Q, Fang JS (2018). Systems pharmacology-based investigation of sanwei ganjiang prescription: related mechanisms in liver injury.. Chinese journal of natural medicines, 16(10), 756-765. https://doi.org/S1875-5364(18)30115-8
Mo Y, Xu E, Wei R, Le B, Song L, Li D, Chen Y, Ji X, Fang S, Shen J, Yang C, Wang Q (2018). Bushen-yizhi formula alleviates neuroinflammation via inhibiting nlrp3 inflammasome activation in a mouse model of parkinson's disease.. Evidence-based complementary and alternative medicine : eCAM, 2018(), 3571604. https://doi.org/10.1155/2018/3571604
Li M, Chen S, Shi X, Lyu C, Zhang Y, Tan M, Wang C, Zang N, Liu X, Hu Y, Shen J, Zhou L, Gu Y (2018). Cell permeable hmgb1-binding heptamer peptide ameliorates neurovascular complications associated with thrombolytic therapy in rats with transient ischemic stroke.. Journal of neuroinflammation, 15(1), 237. https://doi.org/10.1186/s12974-018-1267-5
Chen X, Wu H, Chen H, Wang Q, Xie XJ, Shen J (2019). Astragaloside vi promotes neural stem cell proliferation and enhances neurological function recovery in transient cerebral ischemic injury via activating egfr/mapk signaling cascades.. Molecular neurobiology, 56(4), 3053-3067. https://doi.org/10.1007/s12035-018-1294-3
Li W, Wu H, Gao C, Yang D, Yang D, Shen J (2018). Radix rehmanniae extract ameliorates experimental autoimmune encephalomyelitis by suppressing macrophage-derived nitrative damage.. Frontiers in physiology, 9(), 864. https://doi.org/10.3389/fphys.2018.00864
Gao C, Du Q, Li W, Deng R, Wang Q, Xu A, Shen J (2018). Baicalin modulates appl2/glucocorticoid receptor signaling cascade, promotes neurogenesis, and attenuates emotional and olfactory dysfunctions in chronic corticosterone-induced depression.. Molecular neurobiology, 55(12), 9334-9348. https://doi.org/10.1007/s12035-018-1042-8
Feng J, Chen X, Lu S, Li W, Yang D, Su W, Wang X, Shen J (2018). Naringin attenuates cerebral ischemia-reperfusion injury through inhibiting peroxynitrite-mediated mitophagy activation.. Molecular neurobiology, 55(12), 9029-9042. https://doi.org/10.1007/s12035-018-1027-7
Chen HS, Chen X, Li WT, Shen JG (2018). Targeting rns/caveolin-1/mmp signaling cascades to protect against cerebral ischemia-reperfusion injuries: potential application for drug discovery.. Acta pharmacologica Sinica, 39(5), 669-682. https://doi.org/10.1038/aps.2018.27
Chen X, Zhou B, Yan T, Wu H, Feng J, Chen H, Gao C, Peng T, Yang D, Shen J (2018). Peroxynitrite enhances self-renewal, proliferation and neuronal differentiation of neural stem/progenitor cells through activating hif-1alpha and wnt/beta-catenin signaling pathway.. Free radical biology & medicine, 117(), 158-167. https://doi.org/S0891-5849(18)30056-X
Chen H, Guan B, Chen X, Chen X, Li C, Qiu J, Yang D, Liu KJ, Qi S, Shen J (2018). Baicalin attenuates blood-brain barrier disruption and hemorrhagic transformation and improves neurological outcome in ischemic stroke rats with delayed t-pa treatment: involvement of onoo(-)-mmp-9 pathway.. Translational stroke research, 9(5), 515-529. https://doi.org/10.1007/s12975-017-0598-3
Gao C, Chen X, Xu A, Cheng K, Shen J (2018). Adaptor protein appl2 affects adult antidepressant behaviors and hippocampal neurogenesis via regulating the sensitivity of glucocorticoid receptor.. Molecular neurobiology, 55(7), 5537-5547. https://doi.org/10.1007/s12035-017-0785-y
Tang H, Peng F, Huang X, Xie X, Chen B, Shen J, Gao F, You J, Xie X, Chen J (2018). Neoisoliquiritigenin inhibits tumor progression by targeting grp78-beta- catenin signaling in breast cancer.. Current cancer drug targets, 18(4), 390-399. https://doi.org/10.2174/1568009617666170914155355
Peng F, Tang H, Liu P, Shen J, Guan X, Xie X, Gao J, Xiong L, Jia L, Chen J, Peng C (2017). Isoliquiritigenin modulates mir-374a/pten/akt axis to suppress breast cancer tumorigenesis and metastasis.. Scientific reports, 7(1), 9022. https://doi.org/10.1038/s41598-017-08422-y
Gao C, Shen J (2017). Metabolic factors and adult neurogenesis: impacts of chinese herbal medicine on brain repair in neurological diseases.. International review of neurobiology, 135(), 117-147. https://doi.org/S0074-7742(17)30016-8
Peng T, Chen X, Gao L, Zhang T, Wang W, Shen J, Yang D (2016). A rationally designed rhodamine-based fluorescent probe for molecular imaging of peroxynitrite in live cells and tissues.. Chemical science, 7(8), 5407-5413. https://doi.org/10.1039/c6sc00012f
Qi Z, Liang J, Pan R, Dong W, Shen J, Yang Y, Zhao Y, Shi W, Luo Y, Ji X, Liu KJ (2016). Zinc contributes to acute cerebral ischemia-induced blood-brain barrier disruption.. Neurobiology of disease, 95(), 12-21. https://doi.org/S0969-9961(16)30161-9
Wu H, Deng R, Chen X, Wong WC, Chen H, Gao L, Nie Y, Wu W, Shen J (2016). Caveolin-1 is critical for lymphocyte trafficking into central nervous system during experimental autoimmune encephalomyelitis.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(19), 5193-9. https://doi.org/10.1523/JNEUROSCI.3734-15.2016
Gao L, Chen X, Peng T, Yang D, Wang Q, Lv Z, Shen J (2016). Caveolin-1 protects against hepatic ischemia/reperfusion injury through ameliorating peroxynitrite-mediated cell death.. Free radical biology & medicine, 95(), 209-15. https://doi.org/S0891-5849(16)30002-8
Hu JJ, Wong NK, Lu MY, Chen X, Ye S, Zhao AQ, Gao P, Yi-Tsun Kao R, Shen J, Yang D (2016). Hkocl-3: a fluorescent hypochlorous acid probe for live-cell and in vivo imaging and quantitative application in flow cytometry and a 96-well microplate assay.. Chemical science, 7(3), 2094-2099. https://doi.org/10.1039/c5sc03855c
Hu JJ, Wong NK, Ye S, Chen X, Lu MY, Zhao AQ, Guo Y, Ma AC, Leung AY, Shen J, Yang D (2015). Fluorescent probe hksox-1 for imaging and detection of endogenous superoxide in live cells and in vivo.. Journal of the American Chemical Society, 137(21), 6837-43. https://doi.org/10.1021/jacs.5b01881
Wang N, Wang Z, Wang Y, Xie X, Shen J, Peng C, You J, Peng F, Tang H, Guan X, Chen J (2015). Dietary compound isoliquiritigenin prevents mammary carcinogenesis by inhibiting breast cancer stem cells through wif1 demethylation.. Oncotarget, 6(12), 9854-76.
Gong J, Sun F, Li Y, Zhou X, Duan Z, Duan F, Zhao L, Chen H, Qi S, Shen J (2015). Momordica charantia polysaccharides could protect against cerebral ischemia/reperfusion injury through inhibiting oxidative stress mediated c-jun n-terminal kinase 3 signaling pathway.. Neuropharmacology, 91(), 123-34. https://doi.org/S0028-3908(14)00436-5
Sun H, Shen J, Liu T, Tan Y, Tian D, Luo T, Lai W, Dai M, Guo Z (2014). Heat shock protein 65 promotes atherosclerosis through impairing the properties of high density lipoprotein.. Atherosclerosis, 237(2), 853-61. https://doi.org/S0021-9150(14)01445-2
Wang N, Wang Z, Peng C, You J, Shen J, Han S, Chen J (2014). Dietary compound isoliquiritigenin targets grp78 to chemosensitize breast cancer stem cells via beta-catenin/abcg2 signaling.. Carcinogenesis, 35(11), 2544-54. https://doi.org/10.1093/carcin/bgu187
Gu Y, Lee W, Shen J (2014). Site-2 protease responds to oxidative stress and regulates oxidative injury in mammalian cells.. Scientific reports, 4(), 6268. https://doi.org/10.1038/srep06268
Wang Z, Wang N, Li W, Liu P, Chen Q, Situ H, Zhong S, Guo L, Lin Y, Shen J, Chen J (2014). Caveolin-1 mediates chemoresistance in breast cancer stem cells via beta-catenin/abcg2 signaling pathway.. Carcinogenesis, 35(10), 2346-56. https://doi.org/10.1093/carcin/bgu155
Peng T, Wong NK, Chen X, Chan YK, Sun Z, Hu JJ, Shen J, El-Nezami H, Yang D (2014). Molecular imaging of peroxynitrite with hkgreen-4 in live cells and tissues.. Journal of the American Chemical Society, 136(33), 11728-34. https://doi.org/10.1021/ja504624q
Chen Y, Wu H, Nie YC, Li PB, Shen JG, Su WW (2014). Mucoactive effects of naringin in lipopolysaccharide-induced acute lung injury mice and beagle dogs.. Environmental toxicology and pharmacology, 38(1), 279-87. https://doi.org/S1382-6689(14)00115-X
Hua YQ, Chen Z, Meng ZQ, Chen H, Shen JG, Wang K, Peng W, Shen YH, Liu LM (2014). High expression of erythropoietin-producing hepatoma cell line-b2 (ephb2) predicts the efficiency of the qingyihuaji formula treatment in pancreatic cancer cfpac-1 cells through the ephrinb1-ephb2 pathway.. Oncology letters, 8(1), 17-24.
Fu S, Gu Y, Jiang JQ, Chen X, Xu M, Chen X, Shen J (2014). Calycosin-7-o-beta-d-glucoside regulates nitric oxide /caveolin-1/matrix metalloproteinases pathway and protects blood-brain barrier integrity in experimental cerebral ischemia-reperfusion injury.. Journal of ethnopharmacology, 155(1), 692-701. https://doi.org/S0378-8741(14)00463-2
Chen X, Chen H, Deng R, Shen J (2014). Pros and cons of current approaches for detecting peroxynitrite and their applications.. Biomedical journal, 37(3), 120-6. https://doi.org/10.4103/2319-4170.134084
Gao L, Zhou Y, Zhong W, Zhao X, Chen C, Chen X, Gu Y, Chen J, Lv Z, Shen J (2014). Caveolin-1 is essential for protecting against binge drinking-induced liver damage through inhibiting reactive nitrogen species.. Hepatology (Baltimore, Md.), 60(2), 687-99. https://doi.org/10.1002/hep.27162
Yeung PK, Shen J, Chung SS, Chung SK (2013). Targeted over-expression of endothelin-1 in astrocytes leads to more severe brain damage and vasospasm after subarachnoid hemorrhage.. BMC neuroscience, 14(), 131. https://doi.org/10.1186/1471-2202-14-131
Xu M, Chen X, Gu Y, Peng T, Yang D, Chang RC, So KF, Liu K, Shen J (2013). Baicalin can scavenge peroxynitrite and ameliorate endogenous peroxynitrite-mediated neurotoxicity in cerebral ischemia-reperfusion injury.. Journal of ethnopharmacology, 150(1), 116-24. https://doi.org/S0378-8741(13)00574-6
Wang Z, Wang N, Han S, Wang D, Mo S, Yu L, Huang H, Tsui K, Shen J, Chen J (2013). Dietary compound isoliquiritigenin inhibits breast cancer neoangiogenesis via vegf/vegfr-2 signaling pathway.. PloS one, 8(7), e68566. https://doi.org/10.1371/journal.pone.0068566
Wang Z, Wang D, Han S, Wang N, Mo F, Loo TY, Shen J, Huang H, Chen J (2013). Bioactivity-guided identification and cell signaling technology to delineate the lactate dehydrogenase a inhibition effects of spatholobus suberectus on breast cancer.. PloS one, 8(2), e56631. https://doi.org/10.1371/journal.pone.0056631
Lau BW, Lee JC, Li Y, Fung SM, Sang YH, Shen J, Chang RC, So KF (2012). Polysaccharides from wolfberry prevents corticosterone-induced inhibition of sexual behavior and increases neurogenesis.. PloS one, 7(4), e33374. https://doi.org/10.1371/journal.pone.0033374
Wang N, Wang ZY, Mo SL, Loo TY, Wang DM, Luo HB, Yang DP, Chen YL, Shen JG, Chen JP (2012). Ellagic acid, a phenolic compound, exerts anti-angiogenesis effects via vegfr-2 signaling pathway in breast cancer.. Breast cancer research and treatment, 134(3), 943-55. https://doi.org/10.1007/s10549-012-1977-9
Li Y, Zhuang P, Shen B, Zhang Y, Shen J (2012). Baicalin promotes neuronal differentiation of neural stem/progenitor cells through modulating p-stat3 and bhlh family protein expression.. Brain research, 1429(), 36-42. https://doi.org/10.1016/j.brainres.2011.10.030
Gu Y, Zheng G, Xu M, Li Y, Chen X, Zhu W, Tong Y, Chung SK, Liu KJ, Shen J (2012). Caveolin-1 regulates nitric oxide-mediated matrix metalloproteinases activity and blood-brain barrier permeability in focal cerebral ischemia and reperfusion injury.. Journal of neurochemistry, 120(1), 147-56. https://doi.org/10.1111/j.1471-4159.2011.07542.x
Lee W, Xu M, Li Y, Gu Y, Chen J, Wong D, Fung PC, Shen J (2011). Free cholesterol accumulation impairs antioxidant activities and aggravates apoptotic cell death in menadione-induced oxidative injury.. Archives of biochemistry and biophysics, 514(1-2), 57-67. https://doi.org/10.1016/j.abb.2011.07.014
Li Y, Luo J, Lau WM, Zheng G, Fu S, Wang TT, Zeng HP, So KF, Chung SK, Tong Y, Liu K, Shen J (2011). Caveolin-1 plays a crucial role in inhibiting neuronal differentiation of neural stem/progenitor cells via vegf signaling-dependent pathway.. PloS one, 6(8), e22901. https://doi.org/10.1371/journal.pone.0022901
Li Y, Lau WM, So KF, Tong Y, Shen J (2011). Caveolin-1 inhibits oligodendroglial differentiation of neural stem/progenitor cells through modulating beta-catenin expression.. Neurochemistry international, 59(2), 114-21. https://doi.org/10.1016/j.neuint.2011.05.019
Gu Y, Dee CM, Shen J (2011). Interaction of free radicals, matrix metalloproteinases and caveolin-1 impacts blood-brain barrier permeability.. Frontiers in bioscience (Scholar edition), 3(4), 1216-31.
Wang ZY, Loo TY, Shen JG, Wang N, Wang DM, Yang DP, Mo SL, Guan XY, Chen JP (2012). Ldh-a silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis.. Breast cancer research and treatment, 131(3), 791-800. https://doi.org/10.1007/s10549-011-1466-6
Li Y, Lau WM, So KF, Tong Y, Shen J (2011). Caveolin-1 promote astroglial differentiation of neural stem/progenitor cells through modulating notch1/nicd and hes1 expressions.. Biochemical and biophysical research communications, 407(3), 517-24. https://doi.org/10.1016/j.bbrc.2011.03.050
Shen J, Lee W, Gu Y, Tong Y, Fung PC, Tong L (2011). Ginkgo biloba extract (egb761) inhibits mitochondria-dependent caspase pathway and prevents apoptosis in hypoxia-reoxygenated cardiomyocytes.. Chinese medicine, 6(), 8. https://doi.org/10.1186/1749-8546-6-8
Wang ZY, Wang DM, Loo TY, Cheng Y, Chen LL, Shen JG, Yang DP, Chow LW, Guan XY, Chen JP (2011). Spatholobus suberectus inhibits cancer cell growth by inducing apoptosis and arresting cell cycle at g2/m checkpoint.. Journal of ethnopharmacology, 133(2), 751-8. https://doi.org/10.1016/j.jep.2010.11.004
Yang D, Sun ZN, Peng T, Wang HL, Shen JG, Chen Y, Tam PK (2010). Synthetic fluorescent probes for imaging of peroxynitrite and hypochlorous acid in living cells.. Methods in molecular biology (Clifton, N.J.), 591(), 93-103. https://doi.org/10.1007/978-1-60761-404-3_5
Ye X, Feng Y, Tong Y, Ng KM, Tsao S, Lau GK, Sze C, Zhang Y, Tang J, Shen J, Kobayashi S (2009). Hepatoprotective effects of coptidis rhizoma aqueous extract on carbon tetrachloride-induced acute liver hepatotoxicity in rats.. Journal of ethnopharmacology, 124(1), 130-6.
Shen J, Lee W, Li Y, Lau CF, Ng KM, Fung ML, Liu KJ (2008). Interaction of caveolin-1, nitric oxide, and nitric oxide synthases in hypoxic human sk-n-mc neuroblastoma cells.. Journal of neurochemistry, 107(2), 478-87. https://doi.org/10.1111/j.1471-4159.2008.05630.x
Rong J, Cheung CY, Lau AS, Shen J, Tam PK, Cheng YC (2008). Induction of heme oxygenase-1 by traditional chinese medicine formulation isf-1 and its ingredients as a cytoprotective mechanism against oxidative stress.. International journal of molecular medicine, 21(4), 405-11.
Rong J, Tilton R, Shen J, Ng KM, Liu C, Tam PK, Lau AS, Cheng YC (2007). Genome-wide biological response fingerprinting (bioref) of the chinese botanical formulation isf-1 enables the selection of multiple marker genes as a potential metric for quality control.. Journal of ethnopharmacology, 113(1), 35-44.
Yang D, Wang HL, Sun ZN, Chung NW, Shen JG (2006). A highly selective fluorescent probe for the detection and imaging of peroxynitrite in living cells.. Journal of the American Chemical Society, 128(18), 6004-5.
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Zhong X, Chung AC, Chen HY, Meng XM, Lan HY (2011). Smad3-mediated upregulation of mir-21 promotes renal fibrosis.. Journal of the American Society of Nephrology : JASN, 22(9), 1668-81. https://doi.org/10.1681/ASN.2010111168
Yu S, Xie J, Li PH, Chen Y, Tang IY, Lin X (2024). Therapeutic potential of interleukin-17 neutralization in a novel humanized mouse model of sjogren's disease.. Pharmacological research, 210(), 107524. https://doi.org/S1043-6618(24)00469-9
Du Q, Liang R, Wu M, Yang M, Xie Y, Liu Q, Tang K, Lin X, Yuan S, Shen J (2024). Alisol b 23-acetate broadly inhibits coronavirus through blocking virus entry and suppresses proinflammatory t cells responses for the treatment of covid-19.. Journal of advanced research, 62(), 273-290. https://doi.org/S2090-1232(23)00294-1
Chen Y, Chen J, Jiang Y, Lin X (2023). Clinicopathological analysis of extraneural sporadic haemangioblastoma occurring in the tongue.. BMJ case reports, 16(5), . https://doi.org/10.1136/bcr-2023-255581
Wei Y, Peng N, Deng C, Zhao F, Tian J, Tang Y, Yu S, Chen Y, Xue Y, Xiao F, Zhou Y, Li X, Zou H, Rui K, Lin X, Lu L (2022). Aryl hydrocarbon receptor activation drives polymorphonuclear myeloid-derived suppressor cell response and efficiently attenuates experimental sjogren's syndrome.. Cellular & molecular immunology, 19(12), 1361-1372. https://doi.org/10.1038/s41423-022-00943-5
Wu M, Yu S, Chen Y, Meng W, Chen H, He J, Shen J, Lin X (2022). Acteoside promotes b cell-derived il-10 production and ameliorates autoimmunity.. Journal of leukocyte biology, 112(4), 875-885. https://doi.org/10.1002/JLB.3MA0422-510R
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Wu W, Huang XR, You Y, Xue L, Wang XJ, Meng X, Lin X, Shen J, Yu X, Lan HY, Chen H (2021). Latent tgf-beta1 protects against diabetic kidney disease via arkadia/smad7 signaling.. International journal of biological sciences, 17(13), 3583-3594. https://doi.org/10.7150/ijbs.61647
Lin X, Wang X, Lu L (2021). Detection of il-10 in murine b cells: in vitro and in vivo techniques.. Methods in molecular biology (Clifton, N.J.), 2270(), 93-111. https://doi.org/10.1007/978-1-0716-1237-8_6
Lin X, Lu L (2020). B cell-mediated autoimmune diseases.. Advances in experimental medicine and biology, 1254(), 145-160. https://doi.org/10.1007/978-981-15-3532-1_11
Fu W, Liu X, Lin X, Feng H, Sun L, Li S, Chen H, Tang H, Lu L, Jin W, Dong C (2018). Deficiency in t follicular regulatory cells promotes autoimmunity.. The Journal of experimental medicine, 215(3), 815-825. https://doi.org/10.1084/jem.20170901
Xiao F, Lin X, Tian J, Wang X, Chen Q, Rui K, Ma J, Wang S, Wang Q, Wang X, Liu D, Sun L, Lu L (2017). Proteasome inhibition suppresses th17 cell generation and ameliorates autoimmune development in experimental sjogren's syndrome.. Cellular & molecular immunology, 14(11), 924-34. https://doi.org/10.1038/cmi.2017.8
Rui K, Zhang Z, Tian J, Lin X, Wang X, Ma J, Tang X, Xu H, Lu L, Wang S (2016). Olfactory ecto-mesenchymal stem cells possess immunoregulatory function and suppress autoimmune arthritis.. Cellular & molecular immunology, 13(3), 401-8. https://doi.org/10.1038/cmi.2015.82
Lin X, Liu J, Chung W, Sze SC, Li H, Lao L, Zhang Y (2015). Polysaccharides of dendrobium officinale induce aquaporin 5 translocation by activating m3 muscarinic receptors.. Planta medica, 81(2), 130-7. https://doi.org/10.1055/s-0034-1383411
Lin X, Deng J, Lu L (2014). Il-10 detection in murine b cells: pros and cons of the different techniques.. Methods in molecular biology (Clifton, N.J.), 1190(), 55-69. https://doi.org/10.1007/978-1-4939-1161-5_5
Lin X, Tian J, Rui K, Ma KY, Ko KH, Wang S, Lu L (2014). The role of t helper 17 cell subsets in sjogren's syndrome: similarities and differences between mouse model and humans.. Annals of the rheumatic diseases, 73(7), e43. https://doi.org/10.1136/annrheumdis-2014-205521
Chu H, Zhou J, Wong BH, Li C, Cheng ZS, Lin X, Poon VK, Sun T, Lau CC, Chan JF, To KK, Chan KH, Lu L, Zheng BJ, Yuen KY (2014). Productive replication of middle east respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response.. Virology, 454-455(), 197-205. https://doi.org/S0042-6822(14)00062-2
Lin X, Rui K, Deng J, Tian J, Wang X, Wang S, Ko KH, Jiao Z, Chan VS, Lau CS, Cao X, Lu L (2015). Th17 cells play a critical role in the development of experimental sjogren's syndrome.. Annals of the rheumatic diseases, 74(6), 1302-10. https://doi.org/10.1136/annrheumdis-2013-204584
Lin X, Shaw PC, Sze SC, Tong Y, Zhang Y (2011). Dendrobium officinale polysaccharides ameliorate the abnormality of aquaporin 5, pro-inflammatory cytokines and inhibit apoptosis in the experimental sjogren's syndrome mice.. International immunopharmacology, 11(12), 2025-32. https://doi.org/10.1016/j.intimp.2011.08.014
Lin X, Song JX, Shaw PC, Ng TB, Wong RN, Sze SC, Tong Y, Lee KF, Zhang KY (2011). An autoimmunized mouse model recapitulates key features in the pathogenesis of sjogren's syndrome.. International immunology, 23(10), 613-24. https://doi.org/10.1093/intimm/dxr066
Song JX, Lin X, Wong RN, Sze SC, Tong Y, Shaw PC, Zhang YB (2011). Protective effects of dibenzocyclooctadiene lignans from schisandra chinensis against beta-amyloid and homocysteine neurotoxicity in pc12 cells.. Phytotherapy research : PTR, 25(3), 435-43. https://doi.org/10.1002/ptr.3269
Huang C, Chen G, Luo D, Zheng J, Zhong N, Li D, Luo Y, Huang P, Wang N, Feng Y, Zheng Y (2025). Bbox1, lacc1, mmp7 and sstr1 as common predictors in obesity and non-alcoholic fatty liver disease.. Genes & diseases, 12(2), 101310. https://doi.org/10.1016/j.gendis.2024.101310
Chen G, Ren Q, Zhong Z, Li Q, Huang Z, Zhang C, Yuan H, Feng Z, Chen B, Wang N, Feng Y (2024). Exploring the gut microbiome's role in colorectal cancer: diagnostic and prognostic implications.. Frontiers in immunology, 15(), 1431747. https://doi.org/10.3389/fimmu.2024.1431747
Feng Z, Chan YT, Lu Y, Wu J, Xing T, Yuan H, Feng Y, Wang N (2024). Siwu decoction suppress myeloid-derived suppressor cells through tumour cells necroptosis to inhibit hepatocellular carcinoma.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 133(), 155913. https://doi.org/S0944-7113(24)00571-3
Chan YT, Wu J, Lu Y, Li Q, Feng Z, Xu L, Yuan H, Xing T, Zhang C, Tan HY, Feng Y, Wang N (2024). Loss of lncrna linc01056 leads to sorafenib resistance in hcc.. Molecular cancer, 23(1), 74. https://doi.org/10.1186/s12943-024-01988-y
Wu J, Tan HY, Chan YT, Lu Y, Feng Z, Yuan H, Zhang C, Feng Y, Wang N (2024). Pard3 drives tumorigenesis through activating sonic hedgehog signalling in tumour-initiating cells in liver cancer.. Journal of experimental & clinical cancer research : CR, 43(1), 42. https://doi.org/10.1186/s13046-024-02967-3
Ganotice FA Jr, Mendoza NB, Dizon JIWT, Shen X, Lee JC, Chan E, Luk P, Manio MM, He Q, Khoo US, Lam MPS, Chan SCS, Chow AYM, Wang N, Tipoe GL (2024). Students' motivation and engagement in interprofessional education: the mediating role of peer relatedness.. Medical education online, 29(1), 2430593. https://doi.org/10.1080/10872981.2024.2430593
Liu X, Dong M, Li Y, Li L, Zhang Y, Wang C, Wang N, Wang D (2024). Structural properties of glucan from russula griseocarnosa and its immunomodulatory activities mediated via t cell differentiation.. Carbohydrate polymers, 339(), 122214. https://doi.org/S0144-8617(24)00440-5
Guo YJ, Pang JR, Zhang Y, Li ZR, Zi XL, Liu HM, Wang N, Zhao LJ, Gao Y, Wang B, Herdewijn P, Jin CY, Liu Y, Zheng YC (2024). Neddylation-dependent lsd1 destabilization inhibits the stemness and chemoresistance of gastric cancer.. International journal of biological macromolecules, 254(Pt 3), 126801. https://doi.org/S0141-8130(23)03698-X
Wu J, Chan YT, Lu Y, Feng Z, Yuan H, Xu X, Xu L, Zhang C, Feng Y, Tan HY, Wang N (2023). Genipin-activating ppargamma impedes ccr2-mediated macrophage infiltration into postoperative liver to suppress recurrence of hepatocellular carcinoma.. International journal of biological sciences, 19(16), 5257-5274. https://doi.org/10.7150/ijbs.87327
Lu Y, Chan YT, Wu J, Feng Z, Yuan H, Li Q, Xing T, Xu L, Zhang C, Tan HY, Lee TK, Feng Y, Wang N (2023). Crispr/cas9 screens unravel mir-3689a-3p regulating sorafenib resistance in hepatocellular carcinoma via suppressing ccs/sod1-dependent mitochondrial oxidative stress.. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, 71(), 101015. https://doi.org/S1368-7646(23)00098-5
Chan YT, Tan HY, Lu Y, Zhang C, Cheng CS, Wu J, Wang N, Feng Y (2023). Pancreatic melatonin enhances anti-tumor immunity in pancreatic adenocarcinoma through regulating tumor-associated neutrophils infiltration and netosis.. Acta pharmaceutica Sinica. B, 13(4), 1554-1567. https://doi.org/10.1016/j.apsb.2023.01.020
Lu Y, Liu Y, Lan J, Chan YT, Feng Z, Huang L, Wang N, Pan W, Feng Y (2023). Thioredoxin-interacting protein-activated intracellular potassium deprivation mediates the anti-tumour effect of a novel histone acetylation inhibitor hl23, a fangchinoline derivative, in human hepatocellular carcinoma.. Journal of advanced research, 51(), 181-196. https://doi.org/S2090-1232(22)00246-6
Dai XJ, Liu Y, Wang N, Chen HX, Wu JW, Xiong XP, Ji SK, Zhou Y, Shen L, Wang SP, Liu HM, Liu HM, Zheng YC (2023). Novel acridine-based lsd1 inhibitors enhance immune response in gastric cancer.. European journal of medicinal chemistry, 259(), 115684. https://doi.org/S0223-5234(23)00650-5
Chen X, Liu M, Tang J, Wang N, Feng Y, Ma H (2022). Research progress on the therapeutic effect of polysaccharides on non-alcoholic fatty liver disease through the regulation of the gut-liver axis.. International journal of molecular sciences, 23(19), . https://doi.org/10.3390/ijms231911710
Xu X, Zhang C, Wang N, Xu Y, Tang G, Xu L, Feng Y (2022). Bioactivities and mechanism of actions of dendrobium officinale: a comprehensive review.. Oxidative medicine and cellular longevity, 2022(), 6293355. https://doi.org/10.1155/2022/6293355
Chen G, Luo D, Zhong N, Li D, Zheng J, Liao H, Li Z, Lin X, Chen Q, Zhang C, Lu Y, Chan YT, Ren Q, Wang N, Feng Y (2022). Gpc2 is a potential diagnostic, immunological, and prognostic biomarker in pan-cancer.. Frontiers in immunology, 13(), 857308. https://doi.org/10.3389/fimmu.2022.857308
Zhang C, Tam CW, Tang G, Chen Y, Wang N, Feng Y (2022). Spatial transcriptomic analysis using r-based computational machine learning reveals the genetic profile of yang or yin deficiency syndrome in chinese medicine theory.. Evidence-based complementary and alternative medicine : eCAM, 2022(), 5503181. https://doi.org/10.1155/2022/5503181
Lu Y, Chan YT, Tan HY, Zhang C, Guo W, Xu Y, Sharma R, Chen ZS, Zheng YC, Wang N, Feng Y (2022). Epigenetic regulation of ferroptosis via ets1/mir-23a-3p/acsl4 axis mediates sorafenib resistance in human hepatocellular carcinoma.. Journal of experimental & clinical cancer research : CR, 41(1), 3. https://doi.org/10.1186/s13046-021-02208-x
Shen DD, Pang JR, Bi YP, Zhao LF, Li YR, Zhao LJ, Gao Y, Wang B, Wang N, Wei L, Guo H, Liu HM, Zheng YC (2022). Lsd1 deletion decreases exosomal pd-l1 and restores t-cell response in gastric cancer.. Molecular cancer, 21(1), 75. https://doi.org/10.1186/s12943-022-01557-1
Zhang C, Feng YG, Tam C, Wang N, Feng Y (2021). Transcriptional profiling and machine learning unveil a concordant biosignature of type i interferon-inducible host response across nasal swab and pulmonary tissue for covid-19 diagnosis.. Frontiers in immunology, 12(), 733171. https://doi.org/10.3389/fimmu.2021.733171
Wang N, Wang L, Zhang C, Tan HY, Zhang Y, Feng Y (2021). Berberine suppresses advanced glycation end products-associated diabetic retinopathy in hyperglycemic mice.. Clinical and translational medicine, 11(11), e569. https://doi.org/10.1002/ctm2.569
Wang N, Zhang C, Xu Y, Tan HY, Chen H, Feng Y (2021). Berberine improves insulin-induced diabetic retinopathy through exclusively suppressing akt/mtor-mediated hif-1alpha/vegf activation in retina endothelial cells.. International journal of biological sciences, 17(15), 4316-4326. https://doi.org/10.7150/ijbs.62868
Cheng CS, Tan HY, Wang N, Chen L, Meng Z, Chen Z, Feng Y (2021). Functional inhibition of lactate dehydrogenase suppresses pancreatic adenocarcinoma progression.. Clinical and translational medicine, 11(6), e467. https://doi.org/10.1002/ctm2.467
Xu Y, Wang N, Tan HY, Li S, Zhang C, Feng Y (2021). Gut-liver axis modulation of panax notoginseng saponins in nonalcoholic fatty liver disease.. Hepatology international, 15(2), 350-365. https://doi.org/10.1007/s12072-021-10138-1
Wang N, Tan HY, Lu Y, Chan YT, Wang D, Guo W, Xu Y, Zhang C, Chen F, Tang G, Feng Y (2021). Piwil1 governs the crosstalk of cancer cell metabolism and immunosuppressive microenvironment in hepatocellular carcinoma.. Signal transduction and targeted therapy, 6(1), 86. https://doi.org/10.1038/s41392-021-00485-8
Tan HY, Wang N, Zhang C, Chan YT, Yuen MF, Feng Y (2021). Lysyl oxidase-like 4 fosters an immunosuppressive microenvironment during hepatocarcinogenesis.. Hepatology (Baltimore, Md.), 73(6), 2326-2341. https://doi.org/10.1002/hep.31600
Chen F, Zhong Z, Tan HY, Guo W, Zhang C, Cheng CS, Wang N, Ren J, Feng Y (2020). Suppression of lncrna malat1 by betulinic acid inhibits hepatocellular carcinoma progression by targeting iaps via mir-22-3p.. Clinical and translational medicine, 10(6), e190. https://doi.org/10.1002/ctm2.190
Xu Y, Wang N, Tan HY, Li S, Zhang C, Zhang Z, Feng Y (2020). Panax notoginseng saponins modulate the gut microbiota to promote thermogenesis and beige adipocyte reconstruction via leptin-mediated ampkalpha/stat3 signaling in diet-induced obesity.. Theranostics, 10(24), 11302-11323. https://doi.org/10.7150/thno.47746
Li S, Wang N, Tan HY, Chueng F, Zhang ZJ, Yuen MF, Feng Y (2020). Modulation of gut microbiota mediates berberine-induced expansion of immuno-suppressive cells to against alcoholic liver disease.. Clinical and translational medicine, 10(4), e112. https://doi.org/10.1002/ctm2.112
Guo W, Tan HY, Li S, Wang N, Feng Y (2020). Glutamic-pyruvic transaminase 1 facilitates alternative fuels for hepatocellular carcinoma growth-a small molecule inhibitor, berberine.. Cancers, 12(7), . https://doi.org/10.3390/cancers12071854
Chen F, Zhong Z, Tan HY, Wang N, Feng Y (2020). The significance of circulating tumor cells in patients with hepatocellular carcinoma: real-time monitoring and moving targets for cancer therapy.. Cancers, 12(7), . https://doi.org/10.3390/cancers12071734
Wang X, Zeng J, Wang X, Li J, Chen J, Wang N, Zhang M, Feng Y, Guo H (2020). 2,3,5,4'-tetrahydroxystilbene-2-o-beta-d-glucoside induces autophagy of liver by activating pi3k/akt and erk pathway in prediabetic rats.. BMC complementary medicine and therapies, 20(1), 177. https://doi.org/10.1186/s12906-020-02949-w
Chan YT, Cheung F, Zhang C, Fu B, Tan HY, Norimoto H, Wang N, Feng Y (2020). Ancient chinese medicine herbal formula huanglian jiedu decoction as a neoadjuvant treatment of chemotherapy by improving diarrhea and tumor response.. Frontiers in pharmacology, 11(), 252. https://doi.org/10.3389/fphar.2020.00252
Zhang C, Wang N, Tan HY, Guo W, Chen F, Zhong Z, Man K, Tsao SW, Lao L, Feng Y (2020). Direct inhibition of the tlr4/myd88 pathway by geniposide suppresses hif-1alpha-independent vegf expression and angiogenesis in hepatocellular carcinoma.. British journal of pharmacology, 177(14), 3240-3257. https://doi.org/10.1111/bph.15046
Tan HY, Wang N, Chan YT, Zhang C, Guo W, Chen F, Zhong Z, Li S, Feng Y (2020). Id1 overexpression increases gefitinib sensitivity in non-small cell lung cancer by activating rip3/mlkl-dependent necroptosis.. Cancer letters, 475(), 109-118. https://doi.org/S0304-3835(20)30039-2
Tan HY, Ho VW, Chan YT, Zhang C, Wang N, Xia W, Feng Y (2020). Combination of gentiana rhodantha and gerbera anandria in the bl02 formula as therapeutics to non-small cell lung carcinoma acting via rap1/cdc42 signaling: a transcriptomics/ bio-informatics biological validation approach.. Pharmacological research, 155(), 104415. https://doi.org/S1043-6618(19)30835-7
Wang N, Tan HY, Li S, Wang D, Xu Y, Zhang C, Xia W, Che CM, Feng Y (2019). Sbp2 deficiency in adipose tissue macrophages drives insulin resistance in obesity.. Science advances, 5(8), eaav0198. https://doi.org/10.1126/sciadv.aav0198
Hong M, Shi H, Wang N, Tan HY, Wang Q, Feng Y (2019). Dual effects of chinese herbal medicines on angiogenesis in cancer and ischemic stroke treatments: role of hif-1 network.. Frontiers in pharmacology, 10(), 696. https://doi.org/10.3389/fphar.2019.00696
Qu Y, Dou B, Tan H, Feng Y, Wang N, Wang D (2019). Tumor microenvironment-driven non-cell-autonomous resistance to antineoplastic treatment.. Molecular cancer, 18(1), 69. https://doi.org/10.1186/s12943-019-0992-4
Li S, Wang N, Tan HY, Hong M, Yuen MF, Li H, Feng Y (2018). Expansion of granulocytic, myeloid-derived suppressor cells in response to ethanol-induced acute liver damage.. Frontiers in immunology, 9(), 1524. https://doi.org/10.3389/fimmu.2018.01524
Tan HY, Wang N, Li S, Hong M, Guo W, Man K, Cheng CS, Chen Z, Feng Y (2018). Repression of wt1-mediated lef1 transcription by mangiferin governs beta-catenin-independent wnt signalling inactivation in hepatocellular carcinoma.. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 47(5), 1819-1834. https://doi.org/10.1159/000491063
Zhang C, Xu Y, Tan HY, Li S, Wang N, Zhang Y, Feng Y (2018). Neuroprotective effect of he-ying-qing-re formula on retinal ganglion cell in diabetic retinopathy.. Journal of ethnopharmacology, 214(), 179-189. https://doi.org/S0378-8741(17)33527-4
Liu Y, Yang A, Qu Y, Wang Z, Zhang Y, Liu Y, Wang N, Teng L, Wang D (2018). Ameliorative effects of antrodia cinnamomea polysaccharides against cyclophosphamide-induced immunosuppression related to nrf2/ho-1 signaling in balb/c mice.. International journal of biological macromolecules, 116(), 8-15. https://doi.org/S0141-8130(17)35227-3
Wang N, Tan HY, Chan YT, Guo W, Li S, Feng Y (2017). Identification of wt1 as determinant of heptatocellular carcinoma and its inhibition by chinese herbal medicine salvia chinensis benth and its active ingredient protocatechualdehyde.. Oncotarget, 8(62), 105848-105859. https://doi.org/10.18632/oncotarget.22406
Wang N, Tan HY, Li S, Feng Y (2017). Atg9b deficiency suppresses autophagy and potentiates endoplasmic reticulum stress-associated hepatocyte apoptosis in hepatocarcinogenesis.. Theranostics, 7(8), 2325-2338. https://doi.org/10.7150/thno.18225
Wang N, Wang X, Tan HY, Li S, Tsang CM, Tsao SW, Feng Y (2016). Berberine suppresses cyclin d1 expression through proteasomal degradation in human hepatoma cells.. International journal of molecular sciences, 17(11), . https://doi.org/1899
Tan HY, Wang N, Tsao SW, Che CM, Yuen MF, Feng Y (2016). Ire1alpha inhibition by natural compound genipin on tumour associated macrophages reduces growth of hepatocellular carcinoma.. Oncotarget, 7(28), 43792-43804. https://doi.org/10.18632/oncotarget.9696
Wang N, Xu Q, Tan HY, Hong M, Li S, Yuen MF, Feng Y (2016). Berberine inhibition of fibrogenesis in a rat model of liver fibrosis and in hepatic stellate cells.. Evidence-based complementary and alternative medicine : eCAM, 2016(), 8762345. https://doi.org/10.1155/2016/8762345
Wang X, Wang N, Li H, Liu M, Cao F, Yu X, Zhang J, Tan Y, Xiang L, Feng Y (2016). Up-regulation of pai-1 and down-regulation of upa are involved in suppression of invasiveness and motility of hepatocellular carcinoma cells by a natural compound berberine.. International journal of molecular sciences, 17(4), 577. https://doi.org/10.3390/ijms17040577
Wang L, Wang N, Tan HY, Zhang Y, Feng Y (2015). Protective effect of a chinese medicine formula he-ying-qing-re formula on diabetic retinopathy.. Journal of ethnopharmacology, 169(), 295-304. https://doi.org/S0378-8741(15)00297-4
Wang N, Feng Y, Tan HY, Cheung F, Hong M, Lao L, Nagamatsu T (2015). Inhibition of eukaryotic elongation factor-2 confers to tumor suppression by a herbal formulation huanglian-jiedu decoction in human hepatocellular carcinoma.. Journal of ethnopharmacology, 164(), 309-18. https://doi.org/S0378-8741(15)00103-8
Wang N, Feng Y, Cheung F, Wang X, Zhang Z, Feng Y (2015). A chinese medicine formula gegen qinlian decoction suppresses expansion of human renal carcinoma with inhibition of matrix metalloproteinase-2.. Integrative cancer therapies, 14(1), 75-85. https://doi.org/10.1177/1534735414550036
Wang N, Zhu M, Wang X, Tan HY, Tsao SW, Feng Y (2014). Berberine-induced tumor suppressor p53 up-regulation gets involved in the regulatory network of mir-23a in hepatocellular carcinoma.. Biochimica et biophysica acta, 1839(9), 849-57. https://doi.org/S1874-9399(14)00141-2
Xu B, Wang N, Pan W, Qiu J, Cao P, Zhu M, Feng Y, Liang G (2014). Synthesis and anti-tumor activity evaluation of matijin-su derivatives.. Bioorganic chemistry, 56(), 34-40. https://doi.org/S0045-2068(14)00040-6
Tan HY, Wang N, Tsao SW, Zhang Z, Feng Y (2014). Suppression of vascular endothelial growth factor via inactivation of eukaryotic elongation factor 2 by alkaloids in coptidis rhizome in hepatocellular carcinoma.. Integrative cancer therapies, 13(5), 425-34. https://doi.org/10.1177/1534735413513635
Wang N, Zhu M, Tsao SW, Man K, Zhang Z, Feng Y (2013). Mir-23a-mediated inhibition of topoisomerase 1 expression potentiates cell response to etoposide in human hepatocellular carcinoma.. Molecular cancer, 12(1), 119. https://doi.org/10.1186/1476-4598-12-119
Wang N, Feng Y, Zhu M, Siu FM, Ng KM, Che CM (2013). A novel mechanism of xiap degradation induced by timosaponin aiii in hepatocellular carcinoma.. Biochimica et biophysica acta, 1833(12), 2890-2899. https://doi.org/S0167-4889(13)00293-0
Wang N, Feng Y, Cheung F, Chow OY, Wang X, Su W, Tong Y (2012). A comparative study on the hepatoprotective action of bear bile and coptidis rhizoma aqueous extract on experimental liver fibrosis in rats.. BMC complementary and alternative medicine, 12(), 239. https://doi.org/10.1186/1472-6882-12-239
Wang N, Zhu M, Tsao SW, Man K, Zhang Z, Feng Y (2012). Up-regulation of timp-1 by genipin inhibits mmp-2 activities and suppresses the metastatic potential of human hepatocellular carcinoma.. PloS one, 7(9), e46318. https://doi.org/10.1371/journal.pone.0046318
Feng Y, Wang N, Ye X, Li H, Feng Y, Cheung F, Nagamatsu T (2011). Hepatoprotective effect and its possible mechanism of coptidis rhizoma aqueous extract on carbon tetrachloride-induced chronic liver hepatotoxicity in rats.. Journal of ethnopharmacology, 138(3), 683-90. https://doi.org/10.1016/j.jep.2011.09.032
Wang N, Pan W, Zhu M, Zhang M, Hao X, Liang G, Feng Y (2011). Fangchinoline induces autophagic cell death via p53/sestrin2/ampk signalling in human hepatocellular carcinoma cells.. British journal of pharmacology, 164(2b), 731-42. https://doi.org/10.1111/j.1476-5381.2011.01349.x
Wang N, Feng Y, Xie TN, Su W, Zhu M, Chow O, Zhang Y, Ng KM, Leung CH, Tong Y (2011). Chemical and biological analysis of active free and conjugated bile acids in animal bile using hplc-elsd and mtt methods.. Experimental and therapeutic medicine, 2(1), 125-130.
Wang N, Feng Y, Lau EP, Tsang C, Ching Y, Man K, Tong Y, Nagamatsu T, Su W, Tsao S (2010). F-actin reorganization and inactivation of rho signaling pathway involved in the inhibitory effect of coptidis rhizoma on hepatoma cell migration.. Integrative cancer therapies, 9(4), 354-64. https://doi.org/10.1177/1534735410379121
Wang N, Feng Y, Zhu M, Tsang CM, Man K, Tong Y, Tsao SW (2010). Berberine induces autophagic cell death and mitochondrial apoptosis in liver cancer cells: the cellular mechanism.. Journal of cellular biochemistry, 111(6), 1426-36. https://doi.org/10.1002/jcb.22869
Li D, Wan M, Xue L, Zhang Z, Qiu Y, Mei F, Tang N, Yu C, Yu Y, Chen T, Ding X, Yang Q, Liu Q, Gu P, Jia W, Chen Y, Chen P (2024). Zinc promotes microbial p-coumaric acid production that protects against cholestatic liver injury.. Cell host & microbe, 32(12), 2195-2211.e9. https://doi.org/S1931-3128(24)00408-6
Wang C, Wang L, Zhao Q, Ma J, Li Y, Kuang J, Yang X, Bi H, Lu A, Cheung KCP, Melino G, Jia W (2024). Exploring fructose metabolism as a potential therapeutic approach for pancreatic cancer.. Cell death and differentiation, 31(12), 1625-1635. https://doi.org/10.1038/s41418-024-01394-3
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Zhang Y, Zheng X, Huang F, Zhao A, Ge K, Zhao Q, Jia W (2019). Ursodeoxycholic acid alters bile acid and fatty acid profiles in a mouse model of diet-induced obesity.. Frontiers in pharmacology, 10(), 842. https://doi.org/10.3389/fphar.2019.00842
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Chen YJ, Zhang J, Zhu PP, Tan XW, Lin QH, Wang WX, Yin SS, Gao LZ, Su MM, Liu CX, Xu L, Jia W, Sevrioukova IF, Lan K (2019). Stereoselective oxidation kinetics of deoxycholate in recombinant and microsomal cyp3a enzymes: deoxycholate 19-hydroxylation is an in vitro marker of cyp3a7 activity.. Drug metabolism and disposition: the biological fate of chemicals, 47(6), 574-581. https://doi.org/10.1124/dmd.119.086637
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Wang Z, Katsaros D, Biglia N, Shen Y, Loo L, Yu X, Lin H, Fu Y, Chu WM, Fei P, Ni Y, Jia W, Deng X, Qian B, Yu H (2019). Eralpha upregulates the expression of long non-coding rna linc00472 which suppresses the phosphorylation of nf-kappab in breast cancer.. Breast cancer research and treatment, 175(2), 353-368. https://doi.org/10.1007/s10549-018-05108-5
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Draper CF, Tini G, Vassallo I, Godin JP, Su M, Jia W, Beaumont M, Moco S, Martin FP (2019). Vegan and animal meal composition and timing influence glucose and lipid related postprandial metabolic profiles.. Molecular nutrition & food research, 63(5), e1800568. https://doi.org/10.1002/mnfr.201800568
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Zhang J, Gao LZ, Chen YJ, Zhu PP, Yin SS, Su MM, Ni Y, Miao J, Wu WL, Chen H, Brouwer KLR, Liu CX, Xu L, Jia W, Lan K (2019). Continuum of host-gut microbial co-metabolism: host cyp3a4/3a7 are responsible for tertiary oxidations of deoxycholate species.. Drug metabolism and disposition: the biological fate of chemicals, 47(3), 283-294. https://doi.org/10.1124/dmd.118.085670
Fang C, Du H, Jia W, Xu Y (2018). Compositional differences and similarities between typical chinese baijiu and western liquor as revealed by mass spectrometry-based metabolomics.. Metabolites, 9(1), . https://doi.org/10.3390/metabo9010002
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Zheng X, Wang S, Jia W (2018). Calorie restriction and its impact on gut microbial composition and global metabolism.. Frontiers of medicine, 12(6), 634-644. https://doi.org/10.1007/s11684-018-0670-8
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He Z, Zhang R, Jiang F, Zhang H, Zhao A, Xu B, Jin L, Wang T, Jia W, Jia W, Hu C (2018). Fads1-fads2 genetic polymorphisms are associated with fatty acid metabolism through changes in dna methylation and gene expression.. Clinical epigenetics, 10(1), 113. https://doi.org/10.1186/s13148-018-0545-5
Jia W, Rajani C (2018). The influence of gut microbial metabolism on the development and progression of non-alcoholic fatty liver disease.. Advances in experimental medicine and biology, 1061(), 95-110. https://doi.org/10.1007/978-981-10-8684-7_8
Sun Y, Chen S, Wei R, Xie X, Wang C, Fan S, Zhang X, Su J, Liu J, Jia W, Wang X (2018). Metabolome and gut microbiota variation with long-term intake of panax ginseng extracts on rats.. Food & function, 9(6), 3547-3556. https://doi.org/10.1039/c8fo00025e
Wang Z, Katsaros D, Biglia N, Shen Y, Fu Y, Loo LWM, Jia W, Obata Y, Yu H (2018). High expression of long non-coding rna malat1 in breast cancer is associated with poor relapse-free survival.. Breast cancer research and treatment, 171(2), 261-271. https://doi.org/10.1007/s10549-018-4839-2
Zheng X, Zhou K, Zhang Y, Han X, Zhao A, Liu J, Qu C, Ge K, Huang F, Hernandez B, Yu H, Panee J, Chen T, Jia W, Jia W (2018). Food withdrawal alters the gut microbiota and metabolome in mice.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 32(9), 4878-4888. https://doi.org/10.1096/fj.201700614R
Zhang K, Liu Y, Wang Y, Zhang R, Liu J, Wei J, Qian H, Qian K, Chen R, Liu B (2018). Quantitative sers detection of dopamine in cerebrospinal fluid by dual-recognition-induced hot spot generation.. ACS applied materials & interfaces, 10(18), 15388-15394. https://doi.org/10.1021/acsami.8b01063
Chen T, You Y, Xie G, Zheng X, Zhao A, Liu J, Zhao Q, Wang S, Huang F, Rajani C, Wang C, Chen S, Ni Y, Yu H, Deng Y, Wang X, Jia W (2018). Strategy for an association study of the intestinal microbiome and brain metabolome across the lifespan of rats.. Analytical chemistry, 90(4), 2475-2483. https://doi.org/10.1021/acs.analchem.7b02859
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Bononi A, Yang H, Giorgi C, Patergnani S, Pellegrini L, Su M, Xie G, Signorato V, Pastorino S, Morris P, Sakamoto G, Kuchay S, Gaudino G, Pass HI, Napolitano A, Pinton P, Jia W, Carbone M (2017). Germline bap1 mutations induce a warburg effect.. Cell death and differentiation, 24(10), 1694-1704. https://doi.org/10.1038/cdd.2017.95
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Yang J, Reinach PS, Zhang S, Pan M, Sun W, Liu B, Li F, Li X, Zhao A, Chen T, Jia W, Qu J, Zhou X (2017). Changes in retinal metabolic profiles associated with form deprivation myopia development in guinea pigs.. Scientific reports, 7(1), 2777. https://doi.org/10.1038/s41598-017-03075-3
Jiang R, Tang J, Chen Y, Deng L, Ji J, Xie Y, Wang K, Jia W, Chu WM, Sun B (2017). The long noncoding rna lnc-egfr stimulates t-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion.. Nature communications, 8(), 15129. https://doi.org/10.1038/ncomms15129
Lei S, Huang F, Zhao A, Chen T, Chen W, Xie G, Zheng X, Zhang Y, Yu H, Zhang P, Rajani C, Bao Y, Jia W, Jia W (2017). The ratio of dihomo-gamma-linolenic acid to deoxycholic acid species is a potential biomarker for the metabolic abnormalities in obesity.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(9), 3904-3912. https://doi.org/10.1096/fj.201700055R
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He X, Zheng N, He J, Liu C, Feng J, Jia W, Li H (2017). Gut microbiota modulation attenuated the hypolipidemic effect of simvastatin in high-fat/cholesterol-diet fed mice.. Journal of proteome research, 16(5), 1900-1910. https://doi.org/10.1021/acs.jproteome.6b00984
Xie G, Wang X, Zhao A, Yan J, Chen W, Jiang R, Ji J, Huang F, Zhang Y, Lei S, Ge K, Zheng X, Rajani C, Alegado RA, Liu J, Liu P, Nicholson J, Jia W (2017). Sex-dependent effects on gut microbiota regulate hepatic carcinogenic outcomes.. Scientific reports, 7(), 45232. https://doi.org/10.1038/srep45232
Zhao L, Ni Y, Yu H, Zhang P, Zhao A, Bao Y, Liu J, Chen T, Xie G, Panee J, Chen W, Rajani C, Wei R, Su M, Jia W, Jia W (2017). Serum stearic acid/palmitic acid ratio as a potential predictor of diabetes remission after roux-en-y gastric bypass in obesity.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(4), 1449-1460. https://doi.org/10.1096/fj.201600927R
Chen WL, Wang YY, Zhao A, Xia L, Xie G, Su M, Zhao L, Liu J, Qu C, Wei R, Rajani C, Ni Y, Cheng Z, Chen Z, Chen SJ, Jia W (2016). Enhanced fructose utilization mediated by slc2a5 is a unique metabolic feature of acute myeloid leukemia with therapeutic potential.. Cancer cell, 30(5), 779-791. https://doi.org/S1535-6108(16)30441-X
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Xie G, Wang X, Liu P, Wei R, Chen W, Rajani C, Hernandez BY, Alegado R, Dong B, Li D, Jia W (2016). Distinctly altered gut microbiota in the progression of liver disease.. Oncotarget, 7(15), 19355-66. https://doi.org/10.18632/oncotarget.8466
Panneerselvam J, Xie G, Che R, Su M, Zhang J, Jia W, Fei P (2016). Distinct metabolic signature of human bladder cancer cells carrying an impaired fanconi anemia tumor-suppressor signaling pathway.. Journal of proteome research, 15(4), 1333-41. https://doi.org/10.1021/acs.jproteome.6b00076
Kuo ML, Lee MB, Tang M, den Besten W, Hu S, Sweredoski MJ, Hess S, Chou CM, Changou CA, Su M, Jia W, Su L, Yen Y (2016). Pycr1 and pycr2 interact and collaborate with rrm2b to protect cells from overt oxidative stress.. Scientific reports, 6(), 18846. https://doi.org/10.1038/srep18846
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Martin E, Gonzalez-Horta C, Rager J, Bailey KA, Sanchez-Ramirez B, Ballinas-Casarrubias L, Ishida MC, Gutierrez-Torres DS, Hernandez Ceron R, Viniegra Morales D, Baeza Terrazas FA, Saunders RJ, Drobna Z, Mendez MA, Buse JB, Loomis D, Jia W, Garcia-Vargas GG, Del Razo LM, Styblo M, Fry R (2015). Metabolomic characteristics of arsenic-associated diabetes in a prospective cohort in chihuahua, mexico.. Toxicological sciences : an official journal of the Society of Toxicology, 144(2), 338-46. https://doi.org/10.1093/toxsci/kfu318
Zhong W, Zhang W, Li Q, Xie G, Sun Q, Sun X, Tan X, Sun X, Jia W, Zhou Z (2015). Pharmacological activation of aldehyde dehydrogenase 2 by alda-1 reverses alcohol-induced hepatic steatosis and cell death in mice.. Journal of hepatology, 62(6), 1375-81. https://doi.org/S0168-8278(14)00943-X
Li Q, Xie G, Zhang W, Zhong W, Sun X, Tan X, Sun X, Jia W, Zhou Z (2014). Dietary nicotinic acid supplementation ameliorates chronic alcohol-induced fatty liver in rats.. Alcoholism, clinical and experimental research, 38(7), 1982-92. https://doi.org/10.1111/acer.12396
Zhao L, Wu H, Zhao A, Lu H, Sun W, Ma C, Yang Y, Xin X, Zou H, Qiu M, Jia W (2014). The in vivo and in vitro study of polysaccharides from a two-herb formula on ulcerative colitis and potential mechanism of action.. Journal of ethnopharmacology, 153(1), 151-9. https://doi.org/S0378-8741(14)00109-3
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Tan X, Xie G, Sun X, Li Q, Zhong W, Qiao P, Sun X, Jia W, Zhou Z (2013). High fat diet feeding exaggerates perfluorooctanoic acid-induced liver injury in mice via modulating multiple metabolic pathways.. PloS one, 8(4), e61409. https://doi.org/10.1371/journal.pone.0061409
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Jin C, Liu Y, Sun L, Chen T, Zhang Y, Zhao A, Wang X, Cristau M, Wang K, Jia W (2013). Metabolic profiling reveals disorder of carbohydrate metabolism in mouse fibroblast cells induced by titanium dioxide nanoparticles.. Journal of applied toxicology : JAT, 33(12), 1442-50. https://doi.org/10.1002/jat.2808
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Tan X, Sun X, Li Q, Zhao Y, Zhong W, Sun X, Jia W, McClain CJ, Zhou Z (2012). Leptin deficiency contributes to the pathogenesis of alcoholic fatty liver disease in mice.. The American journal of pathology, 181(4), 1279-86. https://doi.org/S0002-9440(12)00488-9
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Zhang X, Choi FF, Zhou Y, Leung FP, Tan S, Lin S, Xu H, Jia W, Sung JJ, Cai Z, Bian Z (2012). Metabolite profiling of plasma and urine from rats with tnbs-induced acute colitis using uplc-esi-qtof-ms-based metabonomics--a pilot study.. The FEBS journal, 279(13), 2322-38. https://doi.org/10.1111/j.1742-4658.2012.08612.x
Sun X, Tang Y, Tan X, Li Q, Zhong W, Sun X, Jia W, McClain CJ, Zhou Z (2012). Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone improves lipid homeostasis at the adipose tissue-liver axis in ethanol-fed mice.. American journal of physiology. Gastrointestinal and liver physiology, 302(5), G548-57. https://doi.org/10.1152/ajpgi.00342.2011
Wei J, Xie G, Ge S, Qiu Y, Liu W, Lu A, Chen T, Li H, Zhou Z, Jia W (2012). Metabolic transformation of dmba-induced carcinogenesis and inhibitory effect of salvianolic acid b and breviscapine treatment.. Journal of proteome research, 11(2), 1302-16. https://doi.org/10.1021/pr2009725
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Fordahl S, Cooney P, Qiu Y, Xie G, Jia W, Erikson KM (2012). Waterborne manganese exposure alters plasma, brain, and liver metabolites accompanied by changes in stereotypic behaviors.. Neurotoxicology and teratology, 34(1), 27-36. https://doi.org/10.1016/j.ntt.2011.10.003
Xuan J, Pan G, Qiu Y, Yang L, Su M, Liu Y, Chen J, Feng G, Fang Y, Jia W, Xing Q, He L (2011). Metabolomic profiling to identify potential serum biomarkers for schizophrenia and risperidone action.. Journal of proteome research, 10(12), 5433-43. https://doi.org/10.1021/pr2006796
Chi Y, Xia H, Su M, Song P, Qi X, Cui Y, Cao Y, Chen T, Qiu Y, Zhao A, Ma X, Zheng X, Jia W (2011). Metabonomic phenotyping reveals an embryotoxicity of deca-brominated diphenyl ether in mice.. Chemical research in toxicology, 24(11), 1976-83. https://doi.org/10.1021/tx200300v
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Qi X, Zhang Y, Gao J, Chen T, Zhao A, Yan Y, Jia W (2011). Metabolite profiling of hemodialysate using gas chromatography time-of-flight mass spectrometry.. Journal of pharmaceutical and biomedical analysis, 55(5), 1142-7. https://doi.org/10.1016/j.jpba.2011.04.001
Liu Y, Chen T, Qiu Y, Cheng Y, Cao Y, Zhao A, Jia W (2011). An ultrasonication-assisted extraction and derivatization protocol for gc/tofms-based metabolite profiling.. Analytical and bioanalytical chemistry, 400(5), 1405-17. https://doi.org/10.1007/s00216-011-4880-z
Wei H, Dong L, Wang T, Zhang M, Hua W, Zhang C, Pang X, Chen M, Su M, Qiu Y, Zhou M, Yang S, Chen Z, Rantalainen M, Nicholson JK, Jia W, Wu D, Zhao L (2010). Structural shifts of gut microbiota as surrogate endpoints for monitoring host health changes induced by carcinogen exposure.. FEMS microbiology ecology, 73(3), 577-86. https://doi.org/10.1111/j.1574-6941.2010.00924.x
Pan L, Qiu Y, Chen T, Lin J, Chi Y, Su M, Zhao A, Jia W (2010). An optimized procedure for metabonomic analysis of rat liver tissue using gas chromatography/time-of-flight mass spectrometry.. Journal of pharmaceutical and biomedical analysis, 52(4), 589-96. https://doi.org/10.1016/j.jpba.2010.01.046
Xie Z, Li H, Wang K, Lin J, Wang Q, Zhao G, Jia W, Zhang Q (2010). Analysis of transcriptome and metabolome profiles alterations in fatty liver induced by high-fat diet in rat.. Metabolism: clinical and experimental, 59(4), 554-60. https://doi.org/10.1016/j.metabol.2009.08.022
Qiu Y, Cai G, Su M, Chen T, Zheng X, Xu Y, Ni Y, Zhao A, Xu LX, Cai S, Jia W (2009). Serum metabolite profiling of human colorectal cancer using gc-tofms and uplc-qtofms.. Journal of proteome research, 8(10), 4844-50. https://doi.org/10.1021/pr9004162
Xie G, Zheng X, Qi X, Cao Y, Chi Y, Su M, Ni Y, Qiu Y, Liu Y, Li H, Zhao A, Jia W (2010). Metabonomic evaluation of melamine-induced acute renal toxicity in rats.. Journal of proteome research, 9(1), 125-33. https://doi.org/10.1021/pr900333h
Zhao T, Chen T, Qiu Y, Zou X, Li X, Su M, Yan C, Zhao A, Jia W (2009). Trace element profiling using inductively coupled plasma mass spectrometry and its application in an osteoarthritis study.. Analytical chemistry, 81(9), 3683-92. https://doi.org/10.1021/ac900311q
Xie G, Ye M, Wang Y, Ni Y, Su M, Huang H, Qiu M, Zhao A, Zheng X, Chen T, Jia W (2009). Characterization of pu-erh tea using chemical and metabolic profiling approaches.. Journal of agricultural and food chemistry, 57(8), 3046-54. https://doi.org/10.1021/jf804000y
Wang X, Zhao T, Qiu Y, Su M, Jiang T, Zhou M, Zhao A, Jia W (2009). Metabonomics approach to understanding acute and chronic stress in rat models.. Journal of proteome research, 8(5), 2511-8. https://doi.org/10.1021/pr801086k
Dan M, Xie G, Gao X, Long X, Su M, Zhao A, Zhao T, Zhou M, Qiu Y, Jia W (2009). A rapid ultra-performance liquid chromatography-electrospray ionisation mass spectrometric method for the analysis of saponins in the adventitious roots of panax notoginseng.. Phytochemical analysis : PCA, 20(1), 68-76. https://doi.org/10.1002/pca.1099
Li H, Xie Z, Lin J, Song H, Wang Q, Wang K, Su M, Qiu Y, Zhao T, Song K, Wang X, Zhou M, Liu P, Zhao G, Zhang Q, Jia W (2008). Transcriptomic and metabonomic profiling of obesity-prone and obesity-resistant rats under high fat diet.. Journal of proteome research, 7(11), 4775-83. https://doi.org/10.1021/pr800352k
Lin J, Su M, Wang X, Qiu Y, Li H, Hao J, Yang H, Zhou M, Yan C, Jia W (2008). Multiparametric analysis of amino acids and organic acids in rat brain tissues using gc/ms.. Journal of separation science, 31(15), 2831-8. https://doi.org/10.1002/jssc.200800232
Ni Y, Su M, Lin J, Wang X, Qiu Y, Zhao A, Chen T, Jia W (2008). Metabolic profiling reveals disorder of amino acid metabolism in four brain regions from a rat model of chronic unpredictable mild stress.. FEBS letters, 582(17), 2627-36. https://doi.org/10.1016/j.febslet.2008.06.040
Dan M, Su M, Gao X, Zhao T, Zhao A, Xie G, Qiu Y, Zhou M, Liu Z, Jia W (2008). Metabolite profiling of panax notoginseng using uplc-esi-ms.. Phytochemistry, 69(11), 2237-44. https://doi.org/10.1016/j.phytochem.2008.04.015
Shen Q, Li X, Qiu Y, Su M, Liu Y, Li H, Wang X, Zou X, Yan C, Yu L, Li S, Wan C, He L, Jia W (2008). Metabonomic and metallomic profiling in the amniotic fluid of malnourished pregnant rats.. Journal of proteome research, 7(5), 2151-7. https://doi.org/10.1021/pr700776c
Xie G, Plumb R, Su M, Xu Z, Zhao A, Qiu M, Long X, Liu Z, Jia W (2008). Ultra-performance lc/tof ms analysis of medicinal panax herbs for metabolomic research.. Journal of separation science, 31(6-7), 1015-26. https://doi.org/10.1002/jssc.200700650
Qiu Y, Chen M, Su M, Xie G, Li X, Zhou M, Zhao A, Jiang J, Jia W (2008). Metabolic profiling reveals therapeutic effects of herba cistanches in an animal model of hydrocortisone-induced 'kidney-deficiency syndrome'.. Chinese medicine, 3(), 3. https://doi.org/10.1186/1749-8546-3-3
Li M, Wang B, Zhang M, Rantalainen M, Wang S, Zhou H, Zhang Y, Shen J, Pang X, Zhang M, Wei H, Chen Y, Lu H, Zuo J, Su M, Qiu Y, Jia W, Xiao C, Smith LM, Yang S, Holmes E, Tang H, Zhao G, Nicholson JK, Li L, Zhao L (2008). Symbiotic gut microbes modulate human metabolic phenotypes.. Proceedings of the National Academy of Sciences of the United States of America, 105(6), 2117-22. https://doi.org/10.1073/pnas.0712038105
Chen M, Ni Y, Duan H, Qiu Y, Guo C, Jiao Y, Shi H, Su M, Jia W (2008). Mass spectrometry-based metabolic profiling of rat urine associated with general toxicity induced by the multiglycoside of tripterygium wilfordii hook. f.. Chemical research in toxicology, 21(2), 288-94. https://doi.org/10.1021/tx7002905
Zhu Y, Li X, Yue GG, Lee JK, Gao S, Wang M, Wong CK, Xiao WL, Lau CB (2024). Broussoflavonol f exhibited anti-proliferative and anti-angiogenesis effects in colon cancer via modulation of the her2-ras-mek-erk pathway.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 135(), 156243. https://doi.org/S0944-7113(24)00900-0
Xie H, Zhang A, Li J, Mou X, He T, Yeung TC, Lau CBS, Zuo Z, Li P, Kennelly EJ, Leung PC, Tang Y, Fan X, Wang CC, Li L (2024). Cycasin derivative: a potential embryotoxic component of atractylodes macrocephala rhizome for limb malformation.. Toxicology research, 13(2), tfae057. https://doi.org/10.1093/toxres/tfae057
Ma H, Yue GG, Lee JK, Gao S, Yuen KK, Cheng W, Li X, Lau CB (2024). Scutellarin, a flavonoid compound from scutellaria barbata, suppresses growth of breast cancer stem cells in vitro and in tumor-bearing mice.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 128(), 155418. https://doi.org/S0944-7113(24)00083-7
Chan BC, Li P, Tsang MS, Sung JC, Kwong KW, Zheng T, Hon SS, Lau CP, Ho RC, Chen F, Lau CB, Leung PC, Wong CK (2024). Adjuvant activities of immunostimulating natural products: astragalus membranaceus (fisch.) bge. and coriolus versicolor in bnt162b2 vaccination against covid-19 infection.. Journal of leukocyte biology, 115(1), 177-189. https://doi.org/10.1093/jleuko/qiad106
Kan LL, Chan BC, Yue GG, Li P, Hon SS, Huang D, Tsang MS, Lau CB, Leung PC, Wong CK (2024). Immunoregulatory and anti-cancer activities of combination treatment of novel four-herb formula and doxorubicin in 4t1-breast cancer bearing mice.. Chinese journal of integrative medicine, 30(4), 311-321. https://doi.org/10.1007/s11655-023-3745-6
Chan BC, Li P, Tsang MS, Sung JC, Kwong KW, Zheng T, Hon SS, Lau CP, Cheng W, Chen F, Lau CB, Leung PC, Wong CK (2023). Creating a vaccine-like supplement against respiratory infection using recombinant bacillus subtilis spores expressing sars-cov-2 spike protein with natural products.. Molecules (Basel, Switzerland), 28(13), . https://doi.org/10.3390/molecules28134996
Yang H, Zheng T, Ku CF, Ngai CK, Yue GG, Lee HK, Lau CB (2023). Discovery of a heat-generated compound dhd derived from patrinia villosa water extract with inhibitory effects on colon cancer cells viability and migration.. Frontiers in chemistry, 11(), 1195883. https://doi.org/10.3389/fchem.2023.1195883
Yang H, Yue GG, Yuen KK, Gao S, Leung PC, Wong CK, Lau CB (2023). Mechanistic insights into the anti-tumor and anti-metastatic effects of patrinia villosa aqueous extract in colon cancer via modulation of tgf-beta r1-smad2/3-e-cadherin and fak-rhoa-cofilin pathways.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 117(), 154900. https://doi.org/S0944-7113(23)00261-1
Hu YL, Yue GG, Li XR, Xu G, Lau CB (2023). Structurally diverse spirocyclic polycyclic polyprenylated acylphloroglucinols from hypericum ascyron linn. and their anti-tumor activity.. Phytochemistry, 212(), 113727. https://doi.org/S0031-9422(23)00143-7
Gou L, Yue GG, Lee JK, Puno PT, Lau CB (2023). Natural product eriocalyxin b suppressed triple negative breast cancer metastasis both in vitro and in vivo.. Biochemical pharmacology, 210(), 115491. https://doi.org/S0006-2952(23)00082-5
Ma H, Siu WS, Koon CM, Wu XX, Li X, Cheng W, Shum WT, Lau CB, Wong CK, Leung PC (2023). The application of adipose tissue-derived mesenchymal stem cells (admscs) and a twin-herb formula to the rodent wound healing model: use alone or together?. International journal of molecular sciences, 24(2), . https://doi.org/10.3390/ijms24021372
Chan BC, Barua N, Lau CB, Leung PC, Fung KP, Ip M (2023). Enhancing antibiotics efficacy by combination of kuraridin and epicatechin gallate with antimicrobials against methicillin-resistant staphylococcus aureus.. Antibiotics (Basel, Switzerland), 12(1), . https://doi.org/10.3390/antibiotics12010117
Yang H, Yue GG, Leung PC, Wong CK, Zhang YJ, Lau CB (2022). Anti-metastatic effects of 1,2,3,4,6-penta-o-galloyl-beta-d-glucose in colorectal cancer: regulation of cathepsin b-mediated extracellular matrix dynamics and epithelial-to-mesenchymal transition.. Pharmacological research, 184(), 106457. https://doi.org/S1043-6618(22)00403-0
Jiang NN, Gar-Lee Yue G, Li P, Ye YS, Gomes AJ, Hin-Fai Kwok F, Kin-Ming Lee J, Gao S, Lau CB, Xu G (2022). Discovery of dearomatized isoprenylated acylphloroglucinols with colon tumor suppressive activities in mice via inhibiting nfkappab-fat1-pdcd4 signaling activation.. European journal of medicinal chemistry, 239(), 114532. https://doi.org/S0223-5234(22)00434-2
Yue GG, Gomes AJ, Saeed MEM, Tsui KY, Dawood M, Drif AI, Wong EC, Lee WF, Liu W, Chiu PW, Efferth T, Lau CB (2022). Identification of active components in andrographis paniculata targeting on cd81 in esophageal cancer in vitro and in vivo.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 102(), 154183. https://doi.org/S0944-7113(22)00261-6
Lin Q, Liu M, Yue GG, Cheung MK, Lai Z, Kwok FH, Lee JK, Wang Z, Lau CB, Tan N (2022). Anti-inflammatory activities of natural cyclopeptide ra-xii in colitis-associated colon cancer mouse model and its effect on gut microbiome.. Phytotherapy research : PTR, 36(6), 2641-2659. https://doi.org/10.1002/ptr.7482
Cheung MK, Yue GG, Gomes AJ, Wong EC, Lee JK, Kwok FH, Chiu PW, Lau CB (2022). Network pharmacology reveals potential functional components and underlying molecular mechanisms of andrographis paniculata in esophageal cancer treatment.. Phytotherapy research : PTR, 36(4), 1748-1760. https://doi.org/10.1002/ptr.7411
Yang H, Yue GGL, Leung PC, Wong CK, Lau CBS (2022). A review on the molecular mechanisms, the therapeutic treatment including the potential of herbs and natural products, and target prediction of obesity-associated colorectal cancer.. Pharmacological research, 175(), 106031. https://doi.org/S1043-6618(21)00615-0
Yang H, Cheung MK, Yue GG, Leung PC, Wong CK, Lau CB (2021). Integrated network pharmacology analysis and in vitro validation revealed the potential active components and underlying mechanistic pathways of herba patriniae in colorectal cancer.. Molecules (Basel, Switzerland), 26(19), . https://doi.org/10.3390/molecules26196032
Chan BCL, Dharmaratne P, Wang B, Lau KM, Lee CC, Cheung DWS, Chan JYW, Yue GGL, Lau CBS, Wong CK, Fung KP, Ip M (2021). Hypericin and pheophorbide a mediated photodynamic therapy fighting mrsa wound infections: a translational study from in vitro to in vivo.. Pharmaceutics, 13(9), . https://doi.org/10.3390/pharmaceutics13091399
Wu XX, Siu WS, Wat CL, Chan CL, Koon CM, Li X, Cheng W, Ma H, Tsang MSM, Lam CW, Leung PC, Lau CBS, Wong CK (2021). Effects of topical application of a tri-herb formula on inflammatory dry-skin condition in mice with oxazolone-induced atopic dermatitis.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 91(), 153691. https://doi.org/S0944-7113(21)00234-8
Li XX, Chen SG, Yue GG, Kwok HF, Lee JK, Zheng T, Shaw PC, Simmonds MSJ, Lau CB (2021). Natural flavone tricin exerted anti-inflammatory activity in macrophage via nf-kappab pathway and ameliorated acute colitis in mice.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 90(), 153625. https://doi.org/S0944-7113(21)00168-9
Li M, Yue GG, Luo L, Tsui SK, Fung KP, Ng SS, Lau CB (2020). Turmeric is therapeutic in vivo on patient-derived colorectal cancer xenografts: inhibition of growth, metastasis, and tumor recurrence.. Frontiers in oncology, 10(), 574827. https://doi.org/10.3389/fonc.2020.574827
Cheung MK, Yue GGL, Tsui KY, Gomes AJ, Kwan HS, Chiu PWY, Lau CBS (2020). Discovery of an interplay between the gut microbiota and esophageal squamous cell carcinoma in mice.. American journal of cancer research, 10(8), 2409-2427.
Yue GG, Chan YY, Liu W, Gao S, Wong CW, Lee JK, Lau KM, Lau CB (2021). Effectiveness of scutellaria barbata water extract on inhibiting colon tumor growth and metastasis in tumor-bearing mice.. Phytotherapy research : PTR, 35(1), 361-373. https://doi.org/10.1002/ptr.6808
Yue GG, Gao S, Lee JK, Chan YY, Wong EC, Zheng T, Li XX, Shaw PC, Simmonds MSJ, Lau CB (2020). A natural flavone tricin from grains can alleviate tumor growth and lung metastasis in colorectal tumor mice.. Molecules (Basel, Switzerland), 25(16), . https://doi.org/10.3390/molecules25163730
Yue GG, Liang XX, Li XL, Lee JK, Gao S, Kwok HF, Lau CB, Xiao WL (2020). Immunomodulatory and antitumour bioactive labdane diterpenoids from leonurus japonicus.. The Journal of pharmacy and pharmacology, 72(11), 1657-1665. https://doi.org/10.1111/jphp.13348
Mao D, Tian XY, Mao D, Hung SW, Wang CC, Lau CBS, Lee HM, Wong CK, Chow E, Ming X, Cao H, Ma RC, Chan PKS, Kong APS, Li JJX, Rutter GA, Tam WH, Chan JCN (2020). A polysaccharide extract from the medicinal plant maidong inhibits the ikk-nf-kappab pathway and il-1beta-induced islet inflammation and increases insulin secretion.. The Journal of biological chemistry, 295(36), 12573-12587. https://doi.org/10.1074/jbc.RA120.014357
Wu XX, Yue GG, Dong JR, Lam CW, Wong CK, Qiu MH, Lau CB (2020). Actein inhibits tumor growth and metastasis in her2-positive breast tumor bearing mice via suppressing akt/mtor and ras/raf/mapk signaling pathways.. Frontiers in oncology, 10(), 854. https://doi.org/10.3389/fonc.2020.00854
Siu WS, Shiu HT, Shum WT, Ko Chun H, Lau CBS, Hung Leung K, Leung Ping C (2019). Chinese topical herbal medicine gives additive effect on pharmaceutical agent on fracture healing.. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 39(6), 853-860.
Li L, Yin Tang L, Liang B, Wang R, Sun Q, Bik San Lau C, Chung Leung P, Fritsche E, Liebsch M, Seiler Wulczyn AEM, Spielmann H, Wang CC (2019). Evaluation of in vitro embryotoxicity tests for chinese herbal medicines.. Reproductive toxicology (Elmsford, N.Y.), 89(), 45-53. https://doi.org/S0890-6238(18)30688-9
Yue GG, Li L, Lee JK, Kwok HF, Wong EC, Li M, Fung KP, Yu J, Chan AW, Chiu PW, Lau CB (2019). Multiple modulatory activities of andrographis paniculata on immune responses and xenograft growth in esophageal cancer preclinical models.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 60(), 152886. https://doi.org/S0944-7113(19)30056-X
Yue GG, Wong LS, Leung HW, Gao S, Tsang JY, Lin ZX, Tse GM, Lau CB (2019). Evaluation of the safety profiles of estrogenic chinese herbal medicines in breast cancer.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 56(), 103-117. https://doi.org/S0944-7113(18)30524-5
Wu XX, Yue GG, Dong JR, Lam CW, Wong CK, Qiu MH, Lau CB (2018). Actein inhibits the proliferation and adhesion of human breast cancer cells and suppresses migration in vivo.. Frontiers in pharmacology, 9(), 1466. https://doi.org/10.3389/fphar.2018.01466
Yue GG, Lee JK, Chan BC, Kwok HF, Hoi SW, Sze DM, Fung KP, Leung PC, Lau CB (2018). An innovative anti-cancer chinese herbal formula exhibited multi-targeted efficacies in metastatic breast cancer mouse model.. Chinese medicine, 13(), 64. https://doi.org/10.1186/s13020-018-0222-9
Li M, Yue GG, Tsui SK, Fung KP, Lau CB (2018). Turmeric extract, with absorbable curcumin, has potent anti-metastatic effect in vitro and in vivo.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 46(), 131-141. https://doi.org/S0944-7113(18)30100-4
Zeng Q, Ko CH, Siu WS, Li KK, Wong CW, Han XQ, Yang L, Lau CB, Hu JM, Leung PC (2018). Inhibitory effect of different dendrobium species on lps-induced inflammation in macrophages via suppression of mapk pathways.. Chinese journal of natural medicines, 16(7), 481-489. https://doi.org/S1875-5364(18)30083-9
Leung HW, Ko CH, Yue GG, Herr I, Lau CB (2018). The natural agent 4-vinylphenol targets metastasis and stemness features in breast cancer stem-like cells.. Cancer chemotherapy and pharmacology, 82(2), 185-197. https://doi.org/10.1007/s00280-018-3601-0
Zhou X, Cao CY, Wan AT, Yue GG, Kwok FH, Fung KP, Sun H, Lau CB, Puno PT, Tsui SK (2018). Functional roles of eriocalyxin b in zebrafish revealed by transcriptome analysis.. Molecular omics, 14(3), 156-169. https://doi.org/10.1039/c7mo00125h
Wat E, Wang Y, Chan K, Law HW, Koon CM, Lau KM, Leung PC, Yan C, Lau CBS (2018). An in vitro and in vivo study of a 4-herb formula on the management of diet-induced metabolic syndrome.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 42(), 112-125. https://doi.org/S0944-7113(18)30063-1
Li L, Yue GG, Lee JK, Wong EC, Fung KP, Yu J, Lau CB, Chiu PW (2018). Gene expression profiling reveals the plausible mechanisms underlying the antitumor and antimetastasis effects of andrographis paniculata in esophageal cancer.. Phytotherapy research : PTR, 32(7), 1388-1396. https://doi.org/10.1002/ptr.6074
Siu WS, Shiu HT, Ko CH, Shum WT, Yu HN, Lau CB, Hung LK, Leung PC (2017). Integrative approach to facilitate fracture healing: topical chinese herbal paste with oral strontium ranelate.. Evidence-based complementary and alternative medicine : eCAM, 2017(), 9795806. https://doi.org/10.1155/2017/9795806
Li M, Yue GG, Song LH, Huang MB, Lee JK, Tsui SK, Fung KP, Tan NH, Lau CB (2018). Natural small molecule bigelovin suppresses orthotopic colorectal tumor growth and inhibits colorectal cancer metastasis via il6/stat3 pathway.. Biochemical pharmacology, 150(), 191-201. https://doi.org/S0006-2952(18)30074-1
Liu ZK, Ng CF, Shiu HT, Wong HL, Chin WC, Zhang JF, Lam PK, Poon WS, Lau CB, Leung PC, Ko CH (2018). Neuroprotective effect of da chuanxiong formula against cognitive and motor deficits in a rat controlled cortical impact model of traumatic brain injury.. Journal of ethnopharmacology, 217(), 11-22. https://doi.org/S0378-8741(17)32256-0
Wat E, Ng CF, Koon CM, Zhang C, Gao S, Tomlinson B, Lau CBS (2017). The adjuvant value of herba cistanches when used in combination with statin in murine models.. Scientific reports, 7(1), 9391. https://doi.org/10.1038/s41598-017-10008-7
Zeng Q, Ko CH, Siu WS, Li LF, Han XQ, Yang L, Bik-San Lau C, Hu JM, Leung PC (2017). Polysaccharides of dendrobium officinale kimura & migo protect gastric mucosal cell against oxidative damage-induced apoptosis in vitro and in vivo.. Journal of ethnopharmacology, 208(), 214-224. https://doi.org/S0378-8741(17)30766-3
Zhou X, Yue GG, Chan AM, Tsui SK, Fung KP, Sun H, Pu J, Lau CB (2017). Eriocalyxin b, a novel autophagy inducer, exerts anti-tumor activity through the suppression of akt/mtor/p70s6k signaling pathway in breast cancer.. Biochemical pharmacology, 142(), 58-70. https://doi.org/S0006-2952(17)30457-4
Zhou X, Siu WS, Zhang C, Liu CL, Cheng L, Kwok HF, Fung CH, Tam JC, Lau CP, Lau CB, Leung PC, Hung LK, Ko CH (2017). Whole extracts of radix achyranthis bidentatae and radix cyathulae promote angiogenesis in human umbilical vein endothelial cells in vitro and in zebrafish in vivo.. Experimental and therapeutic medicine, 13(3), 1032-1038. https://doi.org/10.3892/etm.2017.4053
Ko CH, Yue GG, Gao S, Luo KW, Siu WS, Shum WT, Shiu HT, Lee JK, Li G, Leung PC, Evdokiou A, Lau CB (2017). Evaluation of the combined use of metronomic zoledronic acid and coriolus versicolor in intratibial breast cancer mouse model.. Journal of ethnopharmacology, 204(), 77-85. https://doi.org/S0378-8741(16)31855-4
Li L, Yue GG, Lee JK, Wong EC, Fung KP, Yu J, Lau CB, Chiu PW (2017). The adjuvant value of andrographis paniculata in metastatic esophageal cancer treatment - from preclinical perspectives.. Scientific reports, 7(1), 854. https://doi.org/10.1038/s41598-017-00934-x
Zhou X, Yue GG, Tsui SK, Pu J, Fung KP, Lau CB (2018). Elaborating the role of natural products on the regulation of autophagy and their potentials in breast cancer therapy.. Current cancer drug targets, 18(3), 239-255. https://doi.org/10.2174/1568009617666170330124819
Li M, Song LH, Yue GG, Lee JK, Zhao LM, Li L, Zhou X, Tsui SK, Ng SS, Fung KP, Tan NH, Lau CB (2017). Bigelovin triggered apoptosis in colorectal cancer in vitro and in vivo via upregulating death receptor 5 and reactive oxidative species.. Scientific reports, 7(), 42176. https://doi.org/10.1038/srep42176
Chan KM, Yue GG, Li P, Wong EC, Lee JK, Kennelly EJ, Lau CB (2017). Screening and analysis of potential anti-tumor components from the stipe of ganoderma sinense using high-performance liquid chromatography/time-of-flight mass spectrometry with multivariate statistical tool.. Journal of chromatography. A, 1487(), 162-167. https://doi.org/S0021-9673(17)30112-7
Liu ZK, Ng CF, Shiu HT, Wong HL, Wong CW, Li KK, Zhang JF, Lam PK, Poon WS, Lau CB, Leung PC, Ko CH (2017). A traditional chinese formula composed of chuanxiong rhizoma and gastrodiae rhizoma (da chuanxiong formula) suppresses inflammatory response in lps -induced raw 264.7 cells through inhibition of nf-kappab pathway.. Journal of ethnopharmacology, 196(), 20-28. https://doi.org/S0378-8741(16)32322-4
Zhou X, Yue GG, Liu M, Zuo Z, Lee JK, Li M, Tsui SK, Fung KP, Sun H, Pu J, Lau CB (2016). Eriocalyxin b, a natural diterpenoid, inhibited vegf-induced angiogenesis and diminished angiogenesis-dependent breast tumor growth by suppressing vegfr-2 signaling.. Oncotarget, 7(50), 82820-82835. https://doi.org/10.18632/oncotarget.12652
Yue GG, Xie S, Lee JK, Kwok HF, Gao S, Nian Y, Wu XX, Wong CK, Qiu MH, Lau CB (2016). New potential beneficial effects of actein, a triterpene glycoside isolated from cimicifuga species, in breast cancer treatment.. Scientific reports, 6(), 35263. https://doi.org/10.1038/srep35263
Koon CM, Zhang X, Chen W, Chu ES, San Lau CB, Wang YX (2016). Black blood t1rho mr imaging may diagnose early stage liver fibrosis: a proof-of-principle study with rat biliary duct ligation model.. Quantitative imaging in medicine and surgery, 6(4), 353-363.
Liu YP, Yue GG, Lee JK, Feng T, Zhao YL, Li Y, Lau CB, Luo XD (2016). Melodinine v, an antitumor bisindole alkaloid with selective cytotoxicity from melodinus henryi.. Bioorganic & medicinal chemistry letters, 26(20), 4895-4898. https://doi.org/S0960-894X(16)30963-5
Siu WS, Ko CH, Wong HL, Gao S, Shum WT, Lau CB, Hung LK, Leung PC (2017). Seropharmacological study on osteogenic effects of post-absorption ingredients of an osteoprotective herbal formula.. Chinese journal of integrative medicine, 23(1), 25-32. https://doi.org/10.1007/s11655-016-2474-5
Wat E, Ng CF, Koon CM, Wong EC, Tomlinson B, Lau CB (2016). The protective effect of herba cistanches on statin-induced myotoxicity in vitro.. Journal of ethnopharmacology, 190(), 68-73. https://doi.org/S0378-8741(16)30377-4
Xian JW, Choi AY, Lau CB, Leung WN, Ng CF, Chan CW (2016). Gastrodia and uncaria (tianma gouteng) water extract exerts antioxidative and antiapoptotic effects against cerebral ischemia in vitro and in vivo.. Chinese medicine, 11(), 27. https://doi.org/10.1186/s13020-016-0097-6
Yue GG, Kwok HF, Lee JK, Jiang L, Wong EC, Gao S, Wong HL, Li L, Chan KM, Leung PC, Fung KP, Zuo Z, Lau CB (2016). Combined therapy using bevacizumab and turmeric ethanolic extract (with absorbable curcumin) exhibited beneficial efficacy in colon cancer mice.. Pharmacological research, 111(), 43-57. https://doi.org/S1043-6618(16)30168-2
Zhou X, Lam WP, Tang HC, Koon CM, Cheng L, Lau CB, Liang W, Leung PC (2016). Effects of gegen (puerariae lobatae radix) water extract on improving detrusor overactivity in spontaneously hypertensive rats.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 23(6), 672-8. https://doi.org/S0944-7113(16)30007-1
Cai Z, Wong CK, Dong J, Jiao D, Chu M, Leung PC, Lau CBS, Lau CP, Tam LS, Lam CWK (2016). Anti-inflammatory activities of ganoderma lucidum (lingzhi) and san-miao-san supplements in mrl/lpr mice for the treatment of systemic lupus erythematosus.. Chinese medicine, 11(), 23. https://doi.org/10.1186/s13020-016-0093-x
Wang YP, Wat E, Koon CM, Wong CW, Cheung DW, Leung PC, Zhao QS, Fung KP, Lau CB (2016). The beneficial potential of polyphenol-enriched fraction from erigerontis herba on metabolic syndrome.. Journal of ethnopharmacology, 187(), 94-103. https://doi.org/S0378-8741(16)30241-0
Ko CH, Lau KM, Chau L, Cheung DW, Siu WS, Wong HL, Shum WT, Gao S, Fung KP, Leung PC, Poon SK, Lau CB (2016). Multitargeted combination effects of a triherbal formulation containing elp against osteoporosis: in vitro evidence.. The Journal of pharmacy and pharmacology, 68(6), 826-33. https://doi.org/10.1111/jphp.12542
Ng CF, Ko CH, Koon CM, Chin WC, Kwong HC, Lo AW, Wong HL, Fung KP, Lau CB, Lam PK, Poon WS, Leung PC (2016). The aqueous extract of rhizome of gastrodia elata blume attenuates locomotor defect and inflammation after traumatic brain injury in rats.. Journal of ethnopharmacology, 185(), 87-95. https://doi.org/S0378-8741(16)30124-6
Yue GG, Lee JK, Li L, Chan KM, Wong EC, Chan JY, Fung KP, Lui VW, Chiu PW, Lau CB (2015). Andrographis paniculata elicits anti-invasion activities by suppressing tm4sf3 gene expression and by anoikis-sensitization in esophageal cancer cells.. American journal of cancer research, 5(12), 3570-87.
Wei W, Xiao HT, Bao WR, Ma DL, Leung CH, Han XQ, Ko CH, Lau CB, Wong CK, Fung KP, Leung PC, Bian ZX, Han QB (2016). Tlr-4 may mediate signaling pathways of astragalus polysaccharide rap induced cytokine expression of raw264.7 cells.. Journal of ethnopharmacology, 179(), 243-52. https://doi.org/S0378-8741(15)30311-1
Leung KC, Seneviratne CJ, Li X, Leung PC, Lau CB, Wong CH, Pang KY, Wong CW, Wat E, Jin L (2016). Synergistic antibacterial effects of nanoparticles encapsulated with scutellaria baicalensis and pure chlorhexidine on oral bacterial biofilms.. Nanomaterials (Basel, Switzerland), 6(4), . https://doi.org/10.3390/nano6040061
Wat E, Ng CF, Wong EC, Koon CM, Lau CP, Cheung DW, Fung KP, Lau CB, Leung PC (2016). The hepatoprotective effect of the combination use of fructus schisandrae with statin--a preclinical evaluation.. Journal of ethnopharmacology, 178(), 104-14. https://doi.org/S0378-8741(15)30255-5
Wong JH, Lau KM, Wu YO, Cheng L, Wong CW, Yew DT, Leung PC, Fung KP, Hui M, Ng TB, Lau CB (2015). Antifungal mode of action of macrocarpal c extracted from eucalyptus globulus labill (lan an) towards the dermatophyte trichophyton mentagrophytes.. Chinese medicine, 10(), 34. https://doi.org/10.1186/s13020-015-0068-3
Leung HW, Zhao SM, Yue GG, Lee JK, Fung KP, Leung PC, Tan NH, Lau CB (2015). Ra-xii inhibits tumour growth and metastasis in breast tumour-bearing mice via reducing cell adhesion and invasion and promoting matrix degradation.. Scientific reports, 5(), 16985. https://doi.org/10.1038/srep16985
Tam JC, Ko CH, Koon CM, Cheng Z, Lok WH, Lau CP, Leung PC, Fung KP, Chan WY, Lau CB (2015). Identification of target genes involved in wound healing angiogenesis of endothelial cells with the treatment of a chinese 2-herb formula.. PloS one, 10(10), e0139342. https://doi.org/10.1371/journal.pone.0139342
Chan BC, Li LF, Hu SQ, Wat E, Wong EC, Zhang VX, Lau CB, Wong CK, Hon KL, Hui PC, Leung PC (2015). Gallic acid is the major active component of cortex moutan in inhibiting immune maturation of human monocyte-derived dendritic cells.. Molecules (Basel, Switzerland), 20(9), 16388-403. https://doi.org/10.3390/molecules200916388
Yue GG, Lee JK, Kwok HF, Cheng L, Wong EC, Jiang L, Yu H, Leung HW, Wong YL, Leung PC, Fung KP, Lau CB (2015). Novel pi3k/akt targeting anti-angiogenic activities of 4-vinylphenol, a new therapeutic potential of a well-known styrene metabolite.. Scientific reports, 5(), 11149. https://doi.org/10.1038/srep11149
Luo KW, Yue GG, Ko CH, Gao S, Lee JK, Li G, Fung KP, Leung PC, Lau CB (2015). The combined use of camellia sinensis and metronomic zoledronate in 4t1 mouse carcinoma against tumor growth and metastasis.. Oncology reports, 34(1), 477-87. https://doi.org/10.3892/or.2015.4001
Leung HW, Wang Z, Yue GG, Zhao SM, Lee JK, Fung KP, Leung PC, Lau CB, Tan NH (2015). Cyclopeptide ra-v inhibits cell adhesion and invasion in both estrogen receptor positive and negative breast cancer cells via pi3k/akt and nf-kappab signaling pathways.. Biochimica et biophysica acta, 1853(8), 1827-40. https://doi.org/S0167-4889(15)00139-1
Siu WS, Ko CH, Lam KW, Wat E, Shum WT, Lau CB, Ko KM, Hung LK, Lau DT, Leung PC (2015). Evaluation of a topical herbal agent for the promotion of bone healing.. Evidence-based complementary and alternative medicine : eCAM, 2015(), 905270. https://doi.org/10.1155/2015/905270
Chen JC, Lau CB, Chan JY, Fung KP, Leung PC, Liu JQ, Zhou L, Xie MJ, Qiu MH (2015). The antigluconeogenic activity of cucurbitacins from momordica charantia.. Planta medica, 81(4), 327-32. https://doi.org/10.1055/s-0035-1545695
Cheng BH, Zhou X, Wang Y, Chan JY, Lin HQ, Or PM, Wan DC, Leung PC, Fung KP, Wang YF, Lau CB (2015). Herb-drug interaction between an anti-hiv chinese herbal sh formula and atazanavir in vitro and in vivo.. Journal of ethnopharmacology, 162(), 369-76. https://doi.org/S0378-8741(15)00018-5
Siu WS, Zhou X, Fung CH, Shum WT, Lau CB, Leung PC, Ko CH, Hung LK (2015). Preclinical evaluations on the efficacy of a topical chinese herbal formula for swelling control and pain relief.. Journal of ethnopharmacology, 162(), 346-51. https://doi.org/S0378-8741(15)00008-2
Luo KW, Ko CH, Yue GG, Gao S, Lee JK, Li G, Fung KP, Leung PC, Evdokiou A, Lau CB (2015). The combined use of camellia sinensis and metronomic zoledronic acid in a breast cancer-induced osteolysis mouse model.. Journal of cancer research and clinical oncology, 141(6), 1025-36. https://doi.org/10.1007/s00432-014-1882-1
Qu Y, Chan JY, Wong CW, Cheng L, Xu C, Leung AW, Lau CB (2015). Antidiabetic effect of schisandrae chinensis fructus involves inhibition of the sodium glucose cotransporter.. Drug development research, 76(1), 1-8. https://doi.org/10.1002/ddr.21233
Wong HL, Siu WS, Fung CH, Zhang C, Shum WT, Zhou XL, Lau CB, Zhang JF, Leung PC, Fu WM, Ko CH (2015). Characteristics of stem cells derived from rat fascia: in vitro proliferative and multilineage potential assessment.. Molecular medicine reports, 11(3), 1982-90. https://doi.org/10.3892/mmr.2014.2967
Lai PK, Chan JY, Kwok HF, Cheng L, Yu H, Lau CP, Leung PC, Fung KP, Lau CB (2014). Induction of angiogenesis in zebrafish embryos and proliferation of endothelial cells by an active fraction isolated from the root of astragalus membranaceus using bioassay-guided fractionation.. Journal of traditional and complementary medicine, 4(4), 239-45. https://doi.org/10.4103/2225-4110.139109
Tam JC, Ko CH, Lau KM, To MH, Kwok HF, Siu WS, Lau CP, Chan WY, Leung PC, Fung KP, Lau CB (2015). Enumeration and functional investigation of endothelial progenitor cells in neovascularization of diabetic foot ulcer rats with a chinese 2-herb formula.. Journal of diabetes, 7(5), 718-28. https://doi.org/10.1111/1753-0407.12230
Lin S, Lai Tc, Chen L, Kwok Hf, Lau CB, Cheung PC (2014). Antioxidant and antiangiogenic properties of phenolic extract from pleurotus tuber-regium.. Journal of agricultural and food chemistry, 62(39), 9488-98. https://doi.org/10.1021/jf5031604
Zhou X, Siu WS, Fung CH, Cheng L, Wong CW, Zhang C, Liu CL, Kwok HF, Lau CP, Wat E, Lau CB, Leung PC, Ko CH, Hung LK (2014). Pro-angiogenic effects of carthami flos whole extract in human microvascular endothelial cells in vitro and in zebrafish in vivo.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 21(11), 1256-63. https://doi.org/S0944-7113(14)00259-1
Seneviratne CJ, Leung KC, Wong CH, Lee SF, Li X, Leung PC, Lau CB, Wat E, Jin L (2014). Nanoparticle-encapsulated chlorhexidine against oral bacterial biofilms.. PloS one, 9(8), e103234. https://doi.org/10.1371/journal.pone.0103234
Ko CH, Koon CM, Yu SL, Lee KY, Lau CB, Chan EH, Wing YK, Fung KP, Leung PC (2016). Hypnotic effects of a novel anti-insomnia formula on drosophila insomnia model.. Chinese journal of integrative medicine, 22(5), 335-43. https://doi.org/10.1007/s11655-014-1625-1
Koon CM, Fong S, Wat E, Wang YP, Wing-Shing Cheung D, Bik-San Lau C, Leung PC, Sun HD, Zhao QS, Fung KP (2014). Mechanisms of the dilator action of the erigerontis herba on rat aorta.. Journal of ethnopharmacology, 155(3), 1561-7. https://doi.org/S0378-8741(14)00572-8
Tam JC, Ko CH, Zhang C, Wang H, Lau CP, Chan WY, Leung PC, Fung KP, Zhang JF, Lau CB (2014). Comprehensive proteomic analysis of a chinese 2-herb formula (astragali radix and rehmanniae radix) on mature endothelial cells.. Proteomics, 14(17-18), 2089-103. https://doi.org/10.1002/pmic.201300547
Zinonos I, Luo KW, Labrinidis A, Liapis V, Hay S, Panagopoulos V, Denichilo M, Ko CH, Yue GG, Lau CB, Ingman W, Ponomarev V, Atkins GJ, Findlay DM, Zannettino AC, Evdokiou A (2014). Pharmacologic inhibition of bone resorption prevents cancer-induced osteolysis but enhances soft tissue metastasis in a mouse model of osteolytic breast cancer.. International journal of oncology, 45(2), 532-40. https://doi.org/10.3892/ijo.2014.2468
Luo KW, Yue GG, Ko CH, Lee JK, Gao S, Li LF, Li G, Fung KP, Leung PC, Lau CB (2014). In vivo and in vitro anti-tumor and anti-metastasis effects of coriolus versicolor aqueous extract on mouse mammary 4t1 carcinoma.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 21(8-9), 1078-87. https://doi.org/S0944-7113(14)00204-9
Yue GG, Chan KM, To MH, Cheng L, Fung KP, Leung PC, Lau CB (2014). Potent airway smooth muscle relaxant effect of cynatratoside b, a steroidal glycoside isolated from cynanchum stauntonii.. Journal of natural products, 77(4), 1074-7. https://doi.org/10.1021/np4008969
Tam JC, Ko CH, Lau KM, To MH, Kwok HF, Chan YW, Siu WS, Etienne-Selloum N, Lau CP, Chan WY, Leung PC, Fung KP, Schini-Kerth VB, Lau CB (2014). A chinese 2-herb formula (nf3) promotes hindlimb ischemia-induced neovascularization and wound healing of diabetic rats.. Journal of diabetes and its complications, 28(4), 436-47. https://doi.org/S1056-8727(14)00059-2
Lau KM, Wong JH, Wu YO, Cheng L, Wong CW, To MH, Lau CP, Yew DT, Leung PC, Fung KP, Hui M, Ng TB, Lau CB (2014). Anti-dermatophytic activity of bakuchiol: in vitro mechanistic studies and in vivo tinea pedis-inhibiting activity in a guinea pig model.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 21(7), 942-5. https://doi.org/S0944-7113(14)00122-6
Luo KW, Ko CH, Yue GG, Lee JK, Li KK, Lee M, Li G, Fung KP, Leung PC, Lau CB (2014). Green tea (camellia sinensis) extract inhibits both the metastasis and osteolytic components of mammary cancer 4t1 lesions in mice.. The Journal of nutritional biochemistry, 25(4), 395-403. https://doi.org/S0955-2863(13)00260-X
Cheng BH, Chan JY, Chan BC, Lin HQ, Han XQ, Zhou X, Wan DC, Wang YF, Leung PC, Fung KP, Lau CB (2014). Structural characterization and immunomodulatory effect of a polysaccharide hcp-2 from houttuynia cordata.. Carbohydrate polymers, 103(), 244-9. https://doi.org/S0144-8617(13)01262-9
Wang CC, Li L, San Lau CB, Leung PC, Fung KP (2013). Pregnancy outcomes, embryonic and fetal development in maternal exposure to chinese medicines.. Birth defects research. Part C, Embryo today : reviews, 99(4), 275-91. https://doi.org/10.1002/bdrc.21050
Liu CL, Kwok HF, Cheng L, Ko CH, Wong CW, Ho TW, Leung PC, Fung KP, Lau CB (2014). Molecular mechanisms of angiogenesis effect of active sub-fraction from root of rehmannia glutinosa by zebrafish sprout angiogenesis-guided fractionation.. Journal of ethnopharmacology, 151(1), 565-75. https://doi.org/S0378-8741(13)00813-1
Chan BC, Lee HY, Siu WS, Yip KH, Ko CH, Lau CB, Leung PC, Lau HY (2014). Suppression of mast cell activity contributes to the osteoprotective effect of an herbal formula containing herba epimedii, fructus ligustri lucidi and fructus psoraleae.. The Journal of pharmacy and pharmacology, 66(3), 437-44. https://doi.org/10.1111/jphp.12166
Koon CM, Ko CH, Sun XX, Hoi SW, Tam JC, Cheung DW, Cheng KF, Pang SY, Lo WM, Chook P, Lau CB, Chan WY, Leung PC, Kwok TC, Fung KP (2013). Gene expression profiling on the molecular action of danshen-gegen formula in a randomized placebo-controlled trial of postmenopausal women with hypercholesterolemia.. Evidence-based complementary and alternative medicine : eCAM, 2013(), 703705. https://doi.org/10.1155/2013/703705
Ng CF, Ko CH, Koon CM, Xian JW, Leung PC, Fung KP, Chan HY, Lau CB (2013). The aqueous extract of rhizome of gastrodia elata protected drosophila and pc12 cells against beta-amyloid-induced neurotoxicity.. Evidence-based complementary and alternative medicine : eCAM, 2013(), 516741. https://doi.org/10.1155/2013/516741
Li LF, Chan BC, Yue GG, Lau CB, Han QB, Leung PC, Liu JK, Fung KP (2013). Two immunosuppressive compounds from the mushroom rubinoboletus ballouii using human peripheral blood mononuclear cells by bioactivity-guided fractionation.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 20(13), 1196-202. https://doi.org/S0944-7113(13)00211-0
Hui PC, Wang WY, Kan CW, Ng FS, Wat E, Zhang VX, Chan CL, Lau CB, Leung PC (2013). Microencapsulation of traditional chinese herbs-pentaherbs extracts and potential application in healthcare textiles.. Colloids and surfaces. B, Biointerfaces, 111(), 156-61. https://doi.org/S0927-7765(13)00362-7
Liu CL, Tam JC, Sanders AJ, Ko CH, Fung KP, Leung PC, Harding KG, Jiang WG, Lau CB (2013). Molecular angiogenic events of a two-herb wound healing formula involving mapk and akt signaling pathways in human vascular endothelial cells.. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 21(4), 579-87. https://doi.org/10.1111/wrr.12055
Lai PK, Chan JY, Wu SB, Cheng L, Ho GK, Lau CP, Kennelly EJ, Leung PC, Fung KP, Lau CB (2014). Anti-inflammatory activities of an active fraction isolated from the root of astragalus membranaceus in raw 264.7 macrophages.. Phytotherapy research : PTR, 28(3), 395-404. https://doi.org/10.1002/ptr.5002
Cheung DW, Koon CM, Wat E, Ko CH, Chan JY, Yew DT, Leung PC, Chan WY, Lau CB, Fung KP (2013). A herbal formula containing roots of salvia miltiorrhiza (danshen) and pueraria lobata (gegen) inhibits inflammatory mediators in lps-stimulated raw 264.7 macrophages through inhibition of nuclear factor kappab (nfkappab) pathway.. Journal of ethnopharmacology, 145(3), 776-83. https://doi.org/S0378-8741(12)00845-8
Ko CH, Siu WS, Wong HL, Gao S, Shum WT, Lau CP, Cheng SW, Tam JC, Hung LK, Fung KP, Lau CB, Han QB, Leung PC (2012). In vivo study on the pharmacological interactions between a chinese herbal formula elp and antiresorptive drugs to counteract osteoporosis.. Evidence-based complementary and alternative medicine : eCAM, 2012(), 203732. https://doi.org/10.1155/2012/203732
Yu X, Tong Y, Han XQ, Kwok HF, Yue GG, Lau CB, Ge W (2013). Anti-angiogenic activity of herba epimedii on zebrafish embryos in vivo and huvecs in vitro.. Phytotherapy research : PTR, 27(9), 1368-75. https://doi.org/10.1002/ptr.4881
He ZH, Yue GG, Lau CB, Ge W, But PP (2012). Antiangiogenic effects and mechanisms of trans-ethyl p-methoxycinnamate from kaempferia galanga l.. Journal of agricultural and food chemistry, 60(45), 11309-17. https://doi.org/10.1021/jf304169j
Zhang Q, Fong CC, Yu WK, Chen Y, Wei F, Koon CM, Lau KM, Leung PC, Lau CB, Fung KP, Yang M (2012). Herbal formula astragali radix and rehmanniae radix exerted wound healing effect on human skin fibroblast cell line hs27 via the activation of transformation growth factor (tgf-beta) pathway and promoting extracellular matrix (ecm) deposition.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 20(1), 9-16. https://doi.org/S0944-7113(12)00316-9
Liu CL, Cheng L, Ko CH, Wong CW, Cheng WH, Cheung DW, Leung PC, Fung KP, Bik-San Lau C (2012). Bioassay-guided isolation of anti-inflammatory components from the root of rehmannia glutinosa and its underlying mechanism via inhibition of inos pathway.. Journal of ethnopharmacology, 143(3), 867-75. https://doi.org/S0378-8741(12)00537-5
Yu X, Tong Y, Kwok HF, Sze SC, Zhong L, Lau CB, Ge W (2012). Anti-angiogenic activity of erxian decoction, a traditional chinese herbal formula, in zebrafish.. Biological & pharmaceutical bulletin, 35(12), 2119-27.
Wing-Shing Cheung D, Koon CM, Ng CF, Leung PC, Fung KP, Kar-Sing Poon S, Bik-San Lau C (2012). The roots of salvia miltiorrhiza (danshen) and pueraria lobata (gegen) inhibit atherogenic events: a study of the combination effects of the 2-herb formula.. Journal of ethnopharmacology, 143(3), 859-66. https://doi.org/S0378-8741(12)00536-3
Lai PK, To MH, Lau KM, Liu CL, Cheng L, Fung KP, Leung PC, Lau CB (2012). Stachyose: one of the active fibroblast-proliferating components in the root of rehmanniae radix ( di huang).. Journal of traditional and complementary medicine, 2(3), 227-34.
Lai PK, Chan JY, Cheng L, Lau CP, Han SQ, Leung PC, Fung KP, Lau CB (2013). Isolation of anti-inflammatory fractions and compounds from the root of astragalus membranaceus.. Phytotherapy research : PTR, 27(4), 581-7. https://doi.org/10.1002/ptr.4759
Siu WS, Wong HL, Lau CP, Shum WT, Wong CW, Gao S, Fung KP, Lau CB, Hung LK, Ko CH, Leung PC (2013). The effects of an antiosteoporosis herbal formula containing epimedii herba, ligustri lucidi fructus and psoraleae fructus on density and structure of rat long bones under tail-suspension, and its mechanisms of action.. Phytotherapy research : PTR, 27(4), 484-92. https://doi.org/10.1002/ptr.4743
He ZH, Gilli C, Yue GG, Lau CB, Greger H, Brecker L, Ge W, But PP (2012). Anti-angiogenic effects and mechanisms of zerumin a from alpinia caerulea.. Food chemistry, 132(1), 201-8. https://doi.org/S0308-8146(11)01510-X
Han XQ, Chung Lap Chan B, Dong CX, Yang YH, Ko CH, Gar-Lee Yue G, Chen D, Wong CK, Bik-San Lau C, Tu PF, Shaw PC, Fung KP, Leung PC, Hsiao WL, Han QB (2012). Isolation, structure characterization, and immunomodulating activity of a hyperbranched polysaccharide from the fruiting bodies of ganoderma sinense.. Journal of agricultural and food chemistry, 60(17), 4276-81. https://doi.org/10.1021/jf205056u
Lau KM, Lai KK, Liu CL, Tam JC, To MH, Kwok HF, Lau CP, Ko CH, Leung PC, Fung KP, Poon SK, Lau CB (2012). Synergistic interaction between astragali radix and rehmanniae radix in a chinese herbal formula to promote diabetic wound healing.. Journal of ethnopharmacology, 141(1), 250-6. https://doi.org/10.1016/j.jep.2012.02.025
Yin JY, Chan BC, Yu H, Lau IY, Han XQ, Cheng SW, Wong CK, Lau CB, Xie MY, Fung KP, Leung PC, Han QB (2012). Separation, structure characterization, conformation and immunomodulating effect of a hyperbranched heteroglycan from radix astragali.. Carbohydrate polymers, 87(1), 667-675. https://doi.org/S0144-8617(11)00729-6
Chan BC, Yu H, Wong CW, Lui SL, Jolivalt C, Ganem-Elbaz C, Paris JM, Morleo B, Litaudon M, Lau CB, Ip M, Fung KP, Leung PC, Han QB (2012). Quick identification of kuraridin, a noncytotoxic anti-mrsa (methicillin-resistant staphylococcus aureus) agent from sophora flavescens using high-speed counter-current chromatography.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 880(1), 157-62. https://doi.org/10.1016/j.jchromb.2011.11.039
Zhang Q, Wei F, Fong CC, Yu WK, Chen Y, Koon CM, Lau KM, Leung PC, Lau CB, Fung KP, Yang M (2011). Transcriptional profiling of human skin fibroblast cell line hs27 induced by herbal formula astragali radix and rehmanniae radix.. Journal of ethnopharmacology, 138(3), 668-75. https://doi.org/10.1016/j.jep.2011.08.080
Fong CC, Wei F, Chen Y, Yu WK, Koon CM, Leung PC, Fung KP, Lau CB, Yang M (2011). Danshen-gegen decoction exerts proliferative effect on rat cardiac myoblasts h9c2 via mapk and insulin pathways.. Journal of ethnopharmacology, 138(1), 60-6. https://doi.org/10.1016/j.jep.2011.08.027
Ko CH, Siu WS, Wong HL, Shum WT, Fung KP, San Lau CB, Leung PC (2011). Pro-bone and antifat effects of green tea and its polyphenol, epigallocatechin, in rat mesenchymal stem cells in vitro.. Journal of agricultural and food chemistry, 59(18), 9870-6. https://doi.org/10.1021/jf202015t
Liu CL, Cheng L, Kwok HF, Ko CH, Lau TW, Koon CM, Zhao M, Lau CP, Lau KM, Wong CW, Leung PC, Fung KP, Lau CB (2011). Bioassay-guided isolation of norviburtinal from the root of rehmannia glutinosa, exhibited angiogenesis effect in zebrafish embryo model.. Journal of ethnopharmacology, 137(3), 1323-7. https://doi.org/10.1016/j.jep.2011.07.060
Chen DP, Wong CK, Leung PC, Fung KP, Lau CB, Lau CP, Li EK, Tam LS, Lam CW (2011). Anti-inflammatory activities of chinese herbal medicine sinomenine and liang miao san on tumor necrosis factor-alpha-activated human fibroblast-like synoviocytes in rheumatoid arthritis.. Journal of ethnopharmacology, 137(1), 457-68. https://doi.org/10.1016/j.jep.2011.05.048
Tam JC, Lau KM, Liu CL, To MH, Kwok HF, Lai KK, Lau CP, Ko CH, Leung PC, Fung KP, Lau CB (2011). The in vivo and in vitro diabetic wound healing effects of a 2-herb formula and its mechanisms of action.. Journal of ethnopharmacology, 134(3), 831-8. https://doi.org/10.1016/j.jep.2011.01.032
Ko CH, Siu WS, Lau CP, Lau CB, Fung KP, Leung PC (2010). Osteoprotective effects of fructus ligustri lucidi aqueous extract in aged ovariectomized rats.. Chinese medicine, 5(), 39. https://doi.org/10.1186/1749-8546-5-39
He ZH, Zhou R, He MF, Lau CB, Yue GG, Ge W, But PP (2011). Anti-angiogenic effect and mechanism of rhein from rhizoma rhei.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 18(6), 470-8. https://doi.org/10.1016/j.phymed.2010.10.006
Lau KM, Fu LH, Cheng L, Wong CW, Wong YL, Lau CP, Han SQ, Chan PK, Fung KP, Lau CB, Hui M, Leung PC (2010). Two antifungal components isolated from fructus psoraleae and folium eucalypti globuli by bioassay-guided purification.. The American journal of Chinese medicine, 38(5), 1005-14.
Han QB, Yu T, Lai F, Zhou Y, Feng C, Wang WN, Fu XH, Lau CB, Luo KQ, Xu HX, Sun HD, Fung KP, Leung PC (2010). Quick identification of apoptosis inducer from isodon eriocalyx by a drug discovery platform composed of analytical high-speed counter-current chromatography and the fluorescence-based caspase-3 biosensor detection.. Talanta, 82(4), 1521-7. https://doi.org/10.1016/j.talanta.2010.07.036
He ZH, Ge W, Yue GG, Lau CB, He MF, But PP (2010). Anti-angiogenic effects of the fruit of alpinia oxyphylla.. Journal of ethnopharmacology, 132(2), 443-9. https://doi.org/10.1016/j.jep.2010.08.024
Kim CF, Jiang JJ, Leung KN, Fung KP, Lau CB (2009). Inhibitory effects of agaricus blazei extracts on human myeloid leukemia cells.. Journal of ethnopharmacology, 122(2), 320-6. https://doi.org/10.1016/j.jep.2008.12.025
Lau KM, Lee KM, Koon CM, Cheung CS, Lau CP, Ho HM, Lee MY, Au SW, Cheng CH, Lau CB, Tsui SK, Wan DC, Waye MM, Wong KB, Wong CK, Lam CW, Leung PC, Fung KP (2008). Immunomodulatory and anti-sars activities of houttuynia cordata.. Journal of ethnopharmacology, 118(1), 79-85. https://doi.org/10.1016/j.jep.2008.03.018
Yue GG, Lau CB, Fung KP, Leung PC, Ko WH (2008). Effects of cordyceps sinensis, cordyceps militaris and their isolated compounds on ion transport in calu-3 human airway epithelial cells.. Journal of ethnopharmacology, 117(1), 92-101. https://doi.org/10.1016/j.jep.2008.01.030
Ho CY, Kim CF, Leung KN, Fung KP, Tse TF, Chan H, Lau CB (2006). Coriolus versicolor (yunzhi) extract attenuates growth of human leukemia xenografts and induces apoptosis through the mitochondrial pathway.. Oncology reports, 16(3), 609-16.
Ho CY, Kim CF, Leung KN, Fung KP, Tse TF, Chan H, Lau CB (2005). Differential anti-tumor activity of coriolus versicolor (yunzhi) extract through p53- and/or bcl-2-dependent apoptotic pathway in human breast cancer cells.. Cancer biology & therapy, 4(6), 638-44.
Zhao J, Sun Y, Feng Y, Rong J (2024). Brain specific raga overexpression triggers depressive-like behaviors in mice via activating adora2a signaling pathway.. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 11(45), e2404188. https://doi.org/10.1002/advs.202404188
Sun Y, Chen Q, Cui W, Chen H, Zhao J, Rong J (2024). Six-compound combo remedy ameliorates corticosterone-induced depressive behaviors in mice via targeting htr1a signaling.. Journal of leukocyte biology, (), . https://doi.org/qiae167
Sun Y, Zhao J, Lu Y, Ngo FY, Shuai B, Zhang ZJ, Feng Y, Rong J (2024). In silico prediction of quercetin analogs for targeting death-associated protein kinase 1 (dapk1) against alzheimer's disease.. Current neuropharmacology, 22(14), 2353-2367. https://doi.org/10.2174/1570159X22666240515090434
Qin Z, Shi DD, Li W, Cheng D, Zhang YD, Zhang S, Tsoi B, Zhao J, Wang Z, Zhang ZJ (2023). Berberine ameliorates depression-like behaviors in mice via inhibiting nlrp3 inflammasome-mediated neuroinflammation and preventing neuroplasticity disruption.. Journal of neuroinflammation, 20(1), 54. https://doi.org/10.1186/s12974-023-02744-7
Zhang X, Chen Q, Zhao J, Zhao W, Fan N, Wang Y, Chen H, Rong J (2023). A four-compound remedy agile protected h9c2 cardiomyocytes against oxygen glucose deprivation via targeting the tnf-alpha/nf-kappab pathway: implications for the therapy of myocardial infarction.. Frontiers in pharmacology, 14(), 1050970. https://doi.org/10.3389/fphar.2023.1050970
Lu J, Hu D, Ma C, Xu X, Shen L, Rong J, Zhao J, Shuai B (2022). Modified qing' e pills exerts anti-osteoporosis effects and prevents bone loss by enhancing type h blood vessel formation.. Frontiers in endocrinology, 13(), 998971. https://doi.org/10.3389/fendo.2022.998971
Fan N, Zhang X, Zhao W, Zhao J, Luo D, Sun Y, Li D, Zhao C, Wang Y, Zhang H, Rong J (2022). Covalent inhibition of pyruvate kinase m2 reprograms metabolic and inflammatory pathways in hepatic macrophages against non-alcoholic fatty liver disease.. International journal of biological sciences, 18(14), 5260-5275. https://doi.org/10.7150/ijbs.73890
Sun Y, Fu J, Yang J, Zhao J, Rong J (2022). Generation of a rraga knockout human ipsc line gibhi002-a-5 using crispr/cas9 technology.. Stem cell research, 63(), 102859. https://doi.org/S1873-5061(22)00208-2
Zhao W, Zhang X, Zhao J, Fan N, Rong J (2022). Sumoylation of nuclear gamma-actin by sumo2 supports dna damage repair against myocardial ischemia-reperfusion injury.. International journal of biological sciences, 18(11), 4595-4609. https://doi.org/10.7150/ijbs.74407
Fan N, Zhao J, Zhao W, Zhang X, Song Q, Shen Y, Shum HC, Wang Y, Rong J (2022). Celastrol-loaded lactosylated albumin nanoparticles attenuate hepatic steatosis in non-alcoholic fatty liver disease.. Journal of controlled release : official journal of the Controlled Release Society, 347(), 44-54. https://doi.org/S0168-3659(22)00230-9
Luo D, Fan N, Zhang X, Ngo FY, Zhao J, Zhao W, Huang M, Li D, Wang Y, Rong J (2022). Covalent inhibition of endoplasmic reticulum chaperone grp78 disconnects the transduction of er stress signals to inflammation and lipid accumulation in diet-induced obese mice.. eLife, 11(), . https://doi.org/10.7554/eLife.72182
Fan N, Zhao J, Zhao W, Shen Y, Song Q, Shum HC, Wang Y, Rong J (2022). Biodegradable celastrol-loaded albumin nanoparticles ameliorate inflammation and lipid accumulation in diet-induced obese mice.. Biomaterials science, 10(4), 984-996. https://doi.org/10.1039/d1bm01637g
Zhao J, Jia Y, Zhao W, Chen H, Zhang X, Ngo FY, Luo D, Song Y, Lao L, Rong J (2021). Botanical drug puerarin ameliorates liposaccharide-induced depressive behaviors in mice via inhibiting raga/mtor/p70s6k pathways.. Oxidative medicine and cellular longevity, 2021(), 7716201. https://doi.org/10.1155/2021/7716201
Zhao W, Zhao J, Zhang X, Fan N, Rong J (2021). Upregulation of small ubiquitin-like modifier 2 and protein sumoylation as a cardioprotective mechanism against myocardial ischemia-reperfusion injury.. Frontiers in pharmacology, 12(), 731980. https://doi.org/10.3389/fphar.2021.731980
Zhao Y, Zhao J, Zhang X, Cheng Y, Luo D, Lee SM, Lao L, Rong J (2020). Botanical drug puerarin promotes neuronal survival and neurite outgrowth against mptp/mpp(+)-induced toxicity via progesterone receptor signaling.. Oxidative medicine and cellular longevity, 2020(), 7635291. https://doi.org/10.1155/2020/7635291
Zhang YB, Lam KH, Chen LF, Wan H, Wang GC, Lee KF, Yip CW, Liu KH, Leung PH, Chan HY, Shi YG, Zhao J, Lao LX, Li YL, Zhang YB, Meng W (2020). Chemical constituents from the thorns of gleditsia sinensis and their cytotoxic activities.. Journal of Asian natural products research, 22(12), 1121-1129. https://doi.org/10.1080/10286020.2020.1731799
Tong KY, Zhao J, Tse CW, Wan PK, Rong J, Au-Yeung HY (2019). Selective catecholamine detection in living cells by a copper-mediated oxidative bond cleavage.. Chemical science, 10(37), 8519-8526. https://doi.org/10.1039/c9sc03338f
Zhao J, Lao L, Cui W, Rong J (2019). Potential link between the raga-mtor-p70s6k axis and depressive-behaviors during bacterial liposaccharide challenge.. Journal of neuroinflammation, 16(1), 211. https://doi.org/10.1186/s12974-019-1610-5
Zhao J, Luo D, Zhang Z, Fan N, Wang Y, Nie H, Rong J (2019). Celastrol-loaded peg-pcl nanomicelles ameliorate inflammation, lipid accumulation, insulin resistance and gastrointestinal injury in diet-induced obese mice.. Journal of controlled release : official journal of the Controlled Release Society, 310(), 188-197. https://doi.org/S0168-3659(19)30510-3
Luo D, Guo Y, Cheng Y, Zhao J, Wang Y, Rong J (2017). Natural product celastrol suppressed macrophage m1 polarization against inflammation in diet-induced obese mice via regulating nrf2/ho-1, map kinase and nf-kappab pathways.. Aging, 9(10), 2069-2082. https://doi.org/10.18632/aging.101302
Luo D, Zhao J, Cheng Y, Lee SM, Rong J (2018). N-propargyl caffeamide (paca) ameliorates dopaminergic neuronal loss and motor dysfunctions in mptp mouse model of parkinson's disease and in mpp(+)-induced neurons via promoting the conversion of prongf to ngf.. Molecular neurobiology, 55(3), 2258-2267. https://doi.org/10.1007/s12035-017-0486-6
Luo D, Zhao J, Rong J (2016). Plant-derived triterpene celastrol ameliorates oxygen glucose deprivation-induced disruption of endothelial barrier assembly via inducing tight junction proteins.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 23(13), 1621-1628. https://doi.org/S0944-7113(16)30182-9
Zhao J, Luo D, Liang Z, Lao L, Rong J (2017). Plant natural product puerarin ameliorates depressive behaviors and chronic pain in mice with spared nerve injury (sni).. Molecular neurobiology, 54(4), 2801-2812. https://doi.org/10.1007/s12035-016-9870-x
Cheng Y, Zhao J, Tse HF, Le XC, Rong J (2015). Plant natural products calycosin and gallic acid synergistically attenuate neutrophil infiltration and subsequent injury in isoproterenol-induced myocardial infarction: a possible role for leukotriene b4 12-hydroxydehydrogenase?. Oxidative medicine and cellular longevity, 2015(), 434052. https://doi.org/10.1155/2015/434052
Yang C, Zhao J, Cheng Y, Le XC, Rong J (2015). N-propargyl caffeate amide (paca) potentiates nerve growth factor (ngf)-induced neurite outgrowth and attenuates 6-hydroxydopamine (6-ohda)-induced toxicity by activating the nrf2/ho-1 pathway.. ACS chemical neuroscience, 6(9), 1560-9. https://doi.org/10.1021/acschemneuro.5b00115
Zhao J, Cheng Y, Yang C, Lau S, Lao L, Shuai B, Cai J, Rong J (2016). Botanical drug puerarin attenuates 6-hydroxydopamine (6-ohda)-induced neurotoxicity via upregulating mitochondrial enzyme arginase-2.. Molecular neurobiology, 53(4), 2200-11. https://doi.org/10.1007/s12035-015-9195-1
Cheng Y, Yang C, Zhao J, Tse HF, Rong J (2015). Proteomic identification of calcium-binding chaperone calreticulin as a potential mediator for the neuroprotective and neuritogenic activities of fruit-derived glycoside amygdalin.. The Journal of nutritional biochemistry, 26(2), 146-54. https://doi.org/S0955-2863(14)00215-0
Zhao J, Cheng YY, Fan W, Yang CB, Ye SF, Cui W, Wei W, Lao LX, Cai J, Han YF, Rong JH (2015). Botanical drug puerarin coordinates with nerve growth factor in the regulation of neuronal survival and neuritogenesis via activating erk1/2 and pi3k/akt signaling pathways in the neurite extension process.. CNS neuroscience & therapeutics, 21(1), 61-70. https://doi.org/10.1111/cns.12334
Yang C, Zhao J, Cheng Y, Li X, Rong J (2014). Bioactivity-guided fractionation identifies amygdalin as a potent neurotrophic agent from herbal medicine semen persicae extract.. BioMed research international, 2014(), 306857. https://doi.org/10.1155/2014/306857
Yang C, Zhao J, Pei W, Zheng X, Rong J (2014). Biochemical mechanisms of bornyl caffeate induced cytotoxicity in rat pheochromocytoma pc12 cells.. Chemico-biological interactions, 219(), 133-42. https://doi.org/S0009-2797(14)00176-8
Yang CB, Pei WJ, Zhao J, Cheng YY, Zheng XH, Rong JH (2014). Bornyl caffeate induces apoptosis in human breast cancer mcf-7 cells via the ros- and jnk-mediated pathways.. Acta pharmacologica Sinica, 35(1), 113-23. https://doi.org/10.1038/aps.2013.162
Qi H, Zhao J, Han Y, Lau AS, Rong J (2012). Z-ligustilide potentiates the cytotoxicity of dopamine in rat dopaminergic pc12 cells.. Neurotoxicity research, 22(4), 345-54.
