You are welcome to attend the Lecture. Please find the details below: 

Speaker:
Professor Chen Zhe-Sheng
Director, Institute for Biotechnology
Professor, Pharmacology
College of Pharmacy and Health Sciences
St. John's University, USA

Moderator:
Professor Feng Yibin
Director, School of Chinese Medicine, HKU

Date: Thursday, 28th  March 2024
Time: 4:00 - 6:00 pm
Venue: Seminar Room 3, G/F, The HKJC Building for Interdisciplinary Research, 5 Sassoon Road, Pokfulam, Hong Kong
Fee: Free of Charge
Registration: Here
Enquires: Tel: 81000538; Email: scmevent@hku.hk

Abstract
The overexpression of ABC transporters in cancer is one of the most common causes of multidrug resistance (MDR). This study investigated the impact of ABC transporters on the resistance to talazoparib (BMN-673), a PARP inhibitor. The mechanism of talazoparib resistance was investigated by constructing talazoparib-resistant subline A2780/T4 through drug selection. Talazoparib cytotoxicity decreased in drug-selected or gene-transfected cell lines overexpressing ABCC1 or ABCG2 but can be restored by ABCC1 or ABCG2 inhibitors. Talazoparib competitively inhibited substrate drug efflux activity of ABCC1 or ABCG2. In vivo experiments confirmed the retention of drug-resistant characteristics in tumor xenograft mouse models. Our results suggest that the overexpression of these transporters can potentially diminish the therapeutic impact of talazoparib in cancer treatment.

About the speaker
Prof. Chen is a Professor at St. John’s University.  He received an MS degree in Toxicology from Sun Yet-Sen University and a Ph. D from Kagoshima University. He conducted postdoctoral training at FCCC. In 2004, he joined the College of Pharmacy at St. John’s University and was promoted to full Professor in 2010. He is an expert in the field of drug resistance in cancer. Prof. Chen is the Editor-In-Chief of Drug Resistance Updates. 

Prof. Chen has given >300 presentations and keynote addresses. He has published > 500 articles. His articles were published in the Chemical Society of Review, Nature Communications, Advanced Materials, Advanced Science, Molecular Cancer, Drug Resistance Updates, Cancer Research, etc. His H-index is 84. His publications have been cited >30,000 times. He participated in grant reviews for the NIH, the Chinese National Natural Science Foundation, etc. Prof. Chen received many awards, including the AACR Young Investigator Award (2003), the Hong Kong Cancer Congress Young Investigator Award (1997), and the St. John’s University Distinguished Achievement Award.